Xerosis

Ritter, Clarice Gabardo

doi:10.1007/978-3-319-33919-1_66

Cited by 4 publications

(9 citation statements)

References 52 publications

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“…In the older adult, xerosis results from a complex interplay of age, health, environmental, and lifestyle factors (Table). As the body ages, epidermal cell renewal and sebum production decline, levels of filaggrin (a protein that derives NMF components) decreases, and transepidermal water loss (TEWL) increases 2,3 . These changes in aging skin, combined with environment and lifestyle factors, produce structural and functional disturbances causing xerosis 3 …”

Section: Risk Factorsmentioning

confidence: 99%

“…The use of leave-on skin care products is the mainstay treatment for xerosis. The aim of skin care products is to restore the structure and function of the epidermis, improve skin barrier functioning, decrease TEWL, reduce inflammation, and decrease itch 3 …”

Section: Topical Treatmentmentioning

confidence: 99%

“…Xerosis, also referred to as dry skin, affects 30% to 99.1% of people older than 60 years 1,2 . Xerosis is usually caused by a lack of epidermal lipids and is the most common cause of pruritus in the older adult 2,3 . Pruritus can result in excessive scratching, skin injury, skin tears, wounds, secondary infection, discomfort, and pain and can have a considerable impact on quality of life 3 .…”

mentioning

confidence: 99%

“…Xerosis predominantly affects the outermost layer of the epidermis, the stratum corneum (SC), which serves as a barrier to the external environment, providing protection against water loss 3 . The SC is composed of corneocytes, which are terminally differentiated keratinocytes that contain natural moisturizing factors (NMFs), such as urea, lactic acid derivatives, pyrrolidine carboxylic acid, amino acids, ammonia, uric acid, and inorganic salts and sugars.…”

mentioning

confidence: 99%

“…1,2 Xerosis is usually caused by a lack of epidermal lipids and is the most common cause of pruritus in the older adult. 2,3 Pruritus can result in excessive scratching, skin injury, skin tears, wounds, secondary infection, discomfort, and pain and can have a considerable impact on quality of life. 3 Although all areas of the body may be generally affected, sites with fewer sebaceous glands, such as the lower legs, forearms, hands, and feet, are more frequently affected.…”

mentioning

confidence: 99%

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Xerosis in Older Adults

Dalgleish

Campbell²

2022

Adv Skin Wound Care

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Xerosis, also referred to as dry skin, affects 30% to 99.1% of people older than 60 years. 1,2 Xerosis is usually caused by a lack of epidermal lipids and is the most common cause of pruritus in the older adult. 2,3 Pruritus can result in excessive scratching, skin injury, skin tears, wounds, secondary infection, discomfort, and pain and can have a considerable impact on quality of life. 3 Although all areas of the body may be generally affected, sites with fewer sebaceous glands, such as the lower legs, forearms, hands, and feet, are more frequently affected. 2 Xerosis predominantly affects the outermost layer of the epidermis, the stratum corneum (SC), which serves as a barrier to the external environment, providing protection against water loss. 3 The SC is composed of corneocytes, which are terminally differentiated keratinocytes that contain natural moisturizing factors (NMFs), such as urea, lactic acid derivatives, pyrrolidine carboxylic acid, amino acids, ammonia, uric acid, and inorganic salts and sugars. These NMFs act as humectants (they attract and bind water to the skin), promoting skin plasticity, optimum skin barrier function, and healthy shedding of skin cells (desquamation). 4 Corneocytes are embedded in a lipid matrix consisting of ceramides, fatty acids, and cholesterol. The lipid matrix prevents water evaporation and is responsible for the chemical barrier of the skin. 2 The SC needs a minimum water content of 10% to remain pliable and avoid fissures. 4

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Section: Risk Factorsmentioning

confidence: 99%

Section: Topical Treatmentmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Xerosis in Older Adults

Dalgleish

Campbell²

2022

Adv Skin Wound Care

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Integrative Approaches to Sleep Management in Skin Disease: Systematic Review

Kulkarni,

Mojica,

Gamsarian

et al. 2023

JMIR Dermatol

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Background Dermatological conditions, especially when severe, can lead to sleep disturbances that affect a patient’s quality of life. However, limited research exists on the efficacy of treatments for improving sleep parameters in skin conditions. Objective The objective was to perform a systematic review of the literature on dermatological conditions and the treatments available for improving sleep parameters. Methods A literature review was performed using the PubMed, Ovid MEDLINE, Embase, Cochrane, and ClinicalTrials.gov databases from 1945 to 2021. After filtering based on our exclusion criteria, studies were graded using the SORT (Strength of Recommendation Taxonomy) algorithm, and only those receiving a grade of “2” or better were included. Results In total, 25 treatment studies (n=11,025) assessing sleep parameters related to dermatological conditions were found. Dupilumab appeared to be the best-supported and most effective treatment for improving sleep in atopic dermatitis (AD) but had frequent adverse effects. Topical treatments for AD were mostly ineffective, but procedural treatments showed some promise. Treatments for other conditions appeared efficacious. Conclusions The evaluation of sleep parameter changes in dermatological treatments is predominantly restricted to AD. Systemic interventions such as dupilumab and procedural interventions were the most efficacious. Sleep changes in other dermatoses were limited by a paucity of available studies. The inclusion of a sleep assessment component to a broader range of dermatological treatment studies is warranted.

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Integrative Approaches to Sleep Management in Skin Disease: Systematic Review (Preprint)

Liu¹

2023

Preprint

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BACKGROUND Dermatological conditions, especially when severe, can lead to sleep disturbances that affect patient quality of life. However, limited research exists on the efficacy of treatments for improving sleep parameters in skin conditions. OBJECTIVE The goal is to investigate the effects of different treatments on sleep disturbances across dermatological conditions. METHODS A literature review was performed using the PubMed, Ovid MEDLINE, EMBASE, Cochrane, and Clinical Trials databases in the years spanning from 1945 to 2021. After filtering based on our exclusion criteria, studies were graded using the SORT algorithm and only those receiving a grade of “2” or better were included. RESULTS 25 treatment studies assessing sleep parameters and relating to dermatological conditions were found. Dupilumab appeared to be the best supported and most effective treatment in improving sleep in atopic dermatitis (AD), but had frequent adverse effects. Topical treatments for AD were mostly ineffective, but procedural treatments showed some promise. Treatments for other conditions appeared efficacious. CONCLUSIONS Evaluation of sleep parameter changes in dermatological treatments is predominantly restricted to AD. Systemic interventions such as dupilumab and procedural interventions were most efficacious. Sleep changes in other dermatoses were limited by a paucity of available studies. Inclusion of a sleep assessment component to a broader range of dermatological treatment studies is warranted.

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Xerosis

Cited by 4 publications

References 52 publications

Xerosis in Older Adults

Xerosis in Older Adults

Integrative Approaches to Sleep Management in Skin Disease: Systematic Review

Integrative Approaches to Sleep Management in Skin Disease: Systematic Review (Preprint)

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