Xiao-Qing-Long-Tang (Sho-seiryu-to) inhibited cytopathic effect of human respiratory syncytial virus in cell lines of human respiratory tract

Chang, Jung San; Yeh, Chia Feng; Wang, Kuo Chih; Shieh, Den En; Yen, Ming Hong; Chiang, Lien Chai

doi:10.1016/j.jep.2013.03.044

Cited by 23 publications

(19 citation statements)

References 27 publications

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“…Shoseiryuto increases the antiviral IgA antibody in nasal and bronchoalveolar washes of infected mice. It did not stimulate type I interferon (IFN) induction in this study (Nagai and Yamada, 1994); however, other in vitro studies with human cell lines have suggested that shoseiryuto shows type I IFN-mediated inhibition of other viruses such as ganciclovir-resistant human cytomegalovirus (Murayama et al, 2006) and human respiratory syncytial virus (Chang et al, 2013). Regarding influenza virus infection, there have been no reports on inhibitory effects on viral growth by shoseiryuto in a cultured-cell system.…”

Section: Shoseiryutocontrasting

confidence: 54%

Kampo Medicines for Infectious Diseases

Komuro

2017

Japanese Kampo Medicines for the Treatment of Common Diseases: Focus on Inflammation

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Section: Shoseiryutocontrasting

confidence: 54%

Kampo Medicines for Infectious Diseases

Komuro

2017

Japanese Kampo Medicines for the Treatment of Common Diseases: Focus on Inflammation

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“…In recent years, many researchers have made efforts to establish basic scientific evidences for the use of several herbal medicines used in traditional Chinese medicine because of evidence-based treatment. For example, it has been reported that Sho-sei-ryu-to and Ma-o-to have antiviral activities against the influenza virus [5–7]. Gingyo-san (GS) has also been reported to have antiviral activity against influenza virus and an immunomodulating activity [8–11].…”

Section: Introductionmentioning

confidence: 99%

The modified Gingyo-san, a Chinese herbal medicine, has direct antibacterial effects against respiratory pathogens

Yamada

Wajima

Nakaminami

et al. 2016

BMC Complement Altern Med

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BackgroundModified Gingyo-san (MGS) is empirically used to treat various respiratory infections. MGS has been reported to have antiinflammatory and antiviral activities; however, it is not known if it has an antibacterial activity. Therefore, in this study, we aimed to investigate the antimicrobial activity of MGS against respiratory pathogens.MethodsMGS, which is sold as an over-the-counter drug in Japan, was used for the study. Antimicrobial activity was evaluated using the disk diffusion method. Growth inhibitory activity was evaluated by measuring colony-forming units of the pathogens in the presence of MGS.ResultsMGS inhibited the growth of Bacillus subtilis, Streptococcus pneumoniae, and Streptococcus pyogenes, which are gram-positive bacteria. Although the growth of most gram-negative bacteria was not inhibited by MGS, interestingly, the growth of Haemophilus influenzae was inhibited. MGS did not show any activity against Candida albicans or bacteriophage φX174.ConclusionsIn addition to the antiinflammatory and antiviral activities of MGS, which have already been reported, the data obtained from this study indicates that MGS has an antibacterial activity.

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“…[37,38] It was also found to effect against human respiratory syncytial virus infection by inhibiting viral attachment, internalization, and syncytial formation. [39] In accordance with these results, a randomized controlled multicenter clinical trial showed TCM treatment could also enhance the quality of life among community-acquired pneumonia patients, and the mortality rate was similar to that of patients treated with antiinfection agents plus conventional medicine. [40] …”

Section: Discussionmentioning

confidence: 69%