Xiaoke Tea, a Chinese Herbal Treatment for Diabetes Mellitus

Hale, P J; Horrocks, P. M.; Wright, Alex; Fitzgerald, M. G.; Nattrass, M.; Bailey, Clifford J.

doi:10.1111/j.1464-5491.1989.tb01255.x

Cited by 21 publications

(20 citation statements)

References 1 publication

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“…36 In the late 1980s, plant extracts from cerasee, 37 xiaoke tea, 38 agrimony, alfalfa, coriander, eucalyptus, and juniper 39 were all reported to have antihyperglycemic effects during the development of diabetes in mice. Recently, various hypoglycemic compounds have been identified, and different possible mechanisms were proposed for different plant extracts that could be preventive and/or curative in diabetic animal models.…”

Section: Discussionmentioning

confidence: 99%

Cyanidin-3-Glucoside-Rich Extract from Chinese Bayberry Fruit Protects Pancreatic β Cells and Ameliorates Hyperglycemia in Streptozotocin-Induced Diabetic Mice

Sun

Zhang²,

Zhang³

et al. 2012

Journal of Medicinal Food

108

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Chinese bayberry fruit is a rich source of anthocyanins, especially cyanidin-3-glucoside (C3G). The present study investigated the protective effects of C3G-rich bayberry fruit extract (CRBFE) against pancreatic β cells against oxidative stress-induced injury as well as its hypoglycemic effect in diabetic mice. Bayberry extract from "Biqi" was used for both in vitro and in vivo testing because of its high C3G content and high antioxidant capacity. Pretreatment of β cells with CRBFE (containing 0.5 μmol/L C3G) prevented cell death, increased cellular viability, and decreased mitochondrial reactive oxygen species production and cell necrosis induced by 800 or 1,200 μmol/L H₂O₂. CRBFE dose-dependently up-regulated pancreatic duodenal homeobox 1 gene expression, contributing to increased insulin-like growth factor II gene transcript levels and insulin protein in INS-1 cells. In addition, administration of CRBFE (150 μg of C3G/10 g of body weight twice per day) significantly reduced blood glucose in streptozotocin-induced diabetic ICR mice and increased the glucose tolerance in an oral glucose tolerance test (P<.05). Such results indicated that CRBFE might be useful in prevention and control of diabetes mellitus and diabetes-associated complications.

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Section: Discussionmentioning

confidence: 99%

Cyanidin-3-Glucoside-Rich Extract from Chinese Bayberry Fruit Protects Pancreatic β Cells and Ameliorates Hyperglycemia in Streptozotocin-Induced Diabetic Mice

Sun

Zhang²,

Zhang³

et al. 2012

Journal of Medicinal Food

108

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“…Among the 119 publications (published in 62 journals, 16 Chinese/Taiwanese and 46 others) one study was published twice: once in English [5] and once in Chinese [6]. Two theoretical papers [7,8] [26,[82][83][84][85][86][87], and 18 miscellaneous [88][89][90][91][92][93][94][95][96][97][98][99][100][101][102][103][104]. We found at least two publications in the following fields: angina pectoris, arterial occlusive disease, asthma, atopic dermatitis, chronic hepatitis, common cold, diabetes mellitus, esophageal precancerous lesion, herpes zoster, menopausal syndrome, rheumatoid arthritis, and aging process (table 2).…”

Section: Resultsmentioning

confidence: 99%

“…More and better designed trials and possibly a systematic review of literature on TCP available in the Western world are needed. Wang [98] Chen [94] without name [93] Shen [92] Shi [67] Jiang [62] Wu [105] Hu [106] Liao [107] Fang [108] Li [68] Drabaek [64] Drabaek [63] Li [78] Hsieh [77] Worm [49] Ramgolam [38] Fung [48] Armstrong [47] Koo [46] Sheehan [44] Sheehan [43] Latchmann [42] Sheehan [40] Sheehan [41] Atherton [39] Batey [25] Akbar [24] Chen [14] Hirayama [13] Caceres [80] Scaglione [72] (continued) Chen [86] Liang [83] Hale [82] Chen [20] Tatsuta [19] Hou [17] Lin [6] Lin [12] Charuwichitratana [71] Sangkitporn [69] Davis [33] Hirata [32] Ding [30] Wang [28] Ramgolam …”

Section: Resultsmentioning

confidence: 99%

Availability of Research Results on Traditional Chinese Pharmacotherapy

Pach¹,

Willich²,

Becker-Witt³

2002

Complement Med Res

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Introduction: The use of Traditional Chinese Medicine (TCM) has been increasing in the Western world over the last few years. Although Traditional Chinese Pharmacotherapy (TCP) plays a central role in TCM treatment in China, acupuncture is a more common form of treatment in the Western world than TCP. Objective: The aim of our study was to evaluate the quantity and availability of clinical trials on TCP using Medline. Methods: Medline searches were performed in PubMed (1966–June 2001) using the MeSH (Medical Subjects Heading) term ‘drugs, Chinese herbal.’ In a second step we restricted the search to meta-analyses, reviews, randomized controlled trials and clinical trials. Additionally we used the PubMed-Research- Methodology-Filter. Abstracts and information concerning the publication type were used to assess the available information. Results: Using the MeSH term ‘drugs, Chinese herbal’, 6,504 publications (50% in Chinese) published in 662 journals were identified. The specific search using the PubMed-Research-Methodology-Filter adjusted to ‘therapy’ and ‘specificity’ identified 118 studies (11 reviews, 55 randomized controlled trials, 26 controlled trials, 7 longitudinal studies, 12 experiments, and 7 others), 65 of which were written in English. Most studies used western diagnoses for treatment. The most common investigated diagnosis was atopic dermatitis (7 trials) followed by angina pectoris (6 trials). Conclusion: Only limited information about TCP research is accessible for physicians using PubMed. Moreover, half of the studies are published in Chinese. The PubMed-Research- Methodology-Filter proved to be an effective tool in restricting the search to relevant publications.

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“…It appears not to affect insulin concentrations and was ineffective in rats that lack endogenous insulin. The trial did not report details about the constituents of the treatment tea, and investigators reported no difference in glycemic parameters as compared with an "ordinary" tea infusion (115). Another controlled clinical trial (n ϭ 148) examined a formulation called Semen Persical Decoction for Purgation with Addition (SPDPA), a combination of eight different herbs and reported decreases in fasting blood glucose not significantly different from changes seen with glyburide (116).…”

Section: Multiple Herb Combinations For Glycemic Controlmentioning

confidence: 99%

Systematic Review of Herbs and Dietary Supplements for Glycemic Control in Diabetes

et al. 2003

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OBJECTIVE -To conduct a systematic review of the published literature on the efficacy and safety of herbal therapies and vitamin/mineral supplements for glucose control in patients with diabetes.RESEARCH DESIGN AND METHODS -We conducted an electronic literature search of MEDLINE, OLDMEDLINE, Cochrane Library Database, and HealthSTAR, from database inception to May 2002, in addition to performing hand searches and consulting with experts in the field. Available clinical studies published in the English language that used human participants and examined glycemic control were included. Data were extracted in a standardized manner, and two independent investigators assessed methodological quality of randomized controlled trials using the Jadad scale.RESULTS -A total of 108 trials examining 36 herbs (single or in combination) and 9 vitamin/ mineral supplements, involving 4,565 patients with diabetes or impaired glucose tolerance, met the inclusion criteria and were analyzed. There were 58 controlled clinical trials involving individuals with diabetes or impaired glucose tolerance (42 randomized and 16 nonrandomized trials). Most studies involved patients with type 2 diabetes. Heterogeneity and the small number of studies per supplement precluded formal meta-analyses. Of these 58 trials, the direction of the evidence for improved glucose control was positive in 76% (44 of 58). Very few adverse effects were reported.CONCLUSIONS -There is still insufficient evidence to draw definitive conclusions about the efficacy of individual herbs and supplements for diabetes; however, they appear to be generally safe. The available data suggest that several supplements may warrant further study. The best evidence for efficacy from adequately designed randomized controlled trials (RCTs) is available for Coccinia indica and American ginseng. Chromium has been the most widely studied supplement. Other supplements with positive preliminary results include Gymnema sylvestre, Aloe vera, vanadium, Momordica charantia, and nopal. Diabetes Care 26:1277-1294, 2003D iabetes is a predominant public health concern, affecting ϳ16 million persons in the U.S. The disease causes substantial morbidity, mortality, and long-term complications and remains an important risk factor for cardiovascular disease. With increasing rates of childhood and adult obesity, diabetes is likely to become even more prevalent over the coming decade (1).In response to the increasing use of complementary and alternative medicine (CAM) among the general public (2,3), the American Diabetes Association issued a Position Statement in 2001 on "Unproven Therapies" that encouraged health care providers to ask their patients about alternative therapies and practices, evaluate each therapy's effectiveness, be cognizant of any potential harm to patients, and acknowledge circumstances in which new and innovative diagnostic or therapeutic measures might be provided to patients (4).Recently, two national surveys have examined CAM use among those with diabetes. One study, using 1996 Me...

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Xiaoke Tea, a Chinese Herbal Treatment for Diabetes Mellitus

Cited by 21 publications

References 1 publication

Cyanidin-3-Glucoside-Rich Extract from Chinese Bayberry Fruit Protects Pancreatic β Cells and Ameliorates Hyperglycemia in Streptozotocin-Induced Diabetic Mice

Cyanidin-3-Glucoside-Rich Extract from Chinese Bayberry Fruit Protects Pancreatic β Cells and Ameliorates Hyperglycemia in Streptozotocin-Induced Diabetic Mice

Availability of Research Results on Traditional Chinese Pharmacotherapy

Systematic Review of Herbs and Dietary Supplements for Glycemic Control in Diabetes

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