Xiaoyin Jiedu Granules may alleviate psoriasis-like skin diseases in mice by regulating sphingosine 1-phosphate receptor expression and reducing Th17 cells

Wang, Zi; Zhang, Guangzhong; Zhang, Haomin; Li, Lingling

doi:10.1016/j.heliyon.2023.e19109

Cited by 2 publications

(1 citation statement)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The relationship between S1PR and psoriasis has been studied extensively. A recent study has shown that S1PR1-5 protein expression is increased in the skin of an IMQinduced psoriasis mouse model and that S1PR1-5 expression is reduced after treatment [113]. In addition, a GWAS study showed that only S1PR1 gene expression decreases in the lesional skin of psoriasis patients compared to non-lesional skin, with no change in the S1PR2-5 gene expression [114].…”

Section: S1p-s1prs In Psoriasismentioning

confidence: 99%

The Role of Sphingolipids and Sphingosine-1-phosphate—Sphingosine-1-phosphate-receptor Signaling in Psoriasis

Masuda-Kuroki,

Alimohammadi,

Di Nardo

2023

Cells

View full text Add to dashboard Cite

Psoriasis is a long-lasting skin condition characterized by redness and thick silver scales on the skin’s surface. It involves various skin cells, including keratinocytes, dendritic cells, T lymphocytes, and neutrophils. The treatments for psoriasis range from topical to systemic therapies, but they only alleviate the symptoms and do not provide a fundamental cure. Moreover, systemic treatments have the disadvantage of suppressing the entire body’s immune system. Therefore, a new treatment strategy with minimal impact on the immune system is required. Recent studies have shown that sphingolipid metabolites, particularly ceramide and sphingosine-1-phosphate (S1P), play a significant role in psoriasis. Specific S1P–S1P-receptor (S1PR) signaling pathways have been identified as crucial to psoriasis inflammation. Based on these findings, S1PR modulators have been investigated and have been found to improve psoriasis inflammation. This review will discuss the metabolic pathways of sphingolipids, the individual functions of these metabolites, and their potential as a new therapeutic approach to psoriasis.

show abstract

Section: S1p-s1prs In Psoriasismentioning

confidence: 99%

The Role of Sphingolipids and Sphingosine-1-phosphate—Sphingosine-1-phosphate-receptor Signaling in Psoriasis

Masuda-Kuroki,

Alimohammadi,

Di Nardo

2023

Cells

View full text Add to dashboard Cite

show abstract

Xiaoyin granules relieve skin lesions in mice with psoriasis through by EGFR-related pathway

Cai,

Zhao,

Shi

et al. 2024

Preprint

View full text Add to dashboard Cite

Background: Psoriasis is a common relapsing chronic inflammatory skin disease, characterized by immune cell infiltration and abnormal proliferation of keratinocytes. Long-term clinical practice has shown that optimized Xiaoyin granules (XYKL) has benefits for patients with mild to moderate psoriasis, and there are no significant adverse reactions. However, the mechanism of action has not been fully deciphered. Objective: This study aims to explore the potential mechanism of XYKL in treating psoriasis through network pharmacology and experimental validation. Methods: The ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS) technique was employed to determine the main components of XYKL. Network pharmacology and molecular docking technology were utilized to screen the active components-targets-pathways for treating psoriasis with XYKL. Additionally, a psoriasis mouse model was created based on the predicted outcomes, and both in vivo and in vitro experiments were conducted to validate the findings. Results: Through network pharmacology analysis, 22 effective ingredients and 70 potential targets associated with psoriasis were selected for XYKL. The “compound-target” network was constructed based on the relationship between compounds and targets. Through PPI network analysis, 26 targets including AKT1, STAT3, EGFR, SRC, ESR1, MMP9, KDR, GSK3B, IL2, and MMP2 were screened. Then, through Gene ontology (GO) enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis, the “ingredient-target-pathway-disease” network was established for these targets. Finally, 10 important chemical ingredients were selected from XYKL, which act on 17 important targets and regulate 13 psoriasis-related biological pathways. In the research conducted in psoriasis mouse models and in vitro cell experiments, it was found that XYKL significantly inhibits the inflammatory levels in psoriasis mice and may promote apoptosis of human immortalized keratinocytes (HaCaT) by inhibiting the EGFR-related signaling pathway and inhibiting their proliferation. Conclusion: This study confirmed the therapeutic effect of XYKL on psoriasis and discovered that XYKL may achieve this effect by inhibiting the EGFR-related signaling pathway to alleviate the inflammatory response of psoriasis, while also inhibiting the proliferation of keratinocytes and promoting their apoptosis.

show abstract

Xiaoyin Jiedu Granules may alleviate psoriasis-like skin diseases in mice by regulating sphingosine 1-phosphate receptor expression and reducing Th17 cells

Cited by 2 publications

References 25 publications

The Role of Sphingolipids and Sphingosine-1-phosphate—Sphingosine-1-phosphate-receptor Signaling in Psoriasis

The Role of Sphingolipids and Sphingosine-1-phosphate—Sphingosine-1-phosphate-receptor Signaling in Psoriasis

Xiaoyin granules relieve skin lesions in mice with psoriasis through by EGFR-related pathway

Contact Info

Product

Resources

About