XIAP inhibitors induce differentiation and impair clonogenic capacity of acute myeloid leukemia stem cells

Moreno-Martínez, Daniel; Nomdedéu, Meritxell; Lara-Castillo, María Carmen; Etxabe, Amaia; Pratcorona, Marta; Tesi, Niccolò; Díaz‐Beyá, Marina; Rozman, Marı́a; Montserrat, Emili; Urbano-Ispizúa, Álvaro; Esteve, Jordi; Risueño, Ruth M.

doi:10.18632/oncotarget.2016

Cited by 24 publications

(19 citation statements)

References 33 publications

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“…However, this study did not include CCC in the PXD arm and the anti-tumor activity of PXD in CCC has not been clarified. In addition, embelin, another XIAP inhibitor, has shown anti-cancer activity in experimental models of several cancers (10)(11)(12)(13), but experiments targeting ovarian CCCs have not been reported.…”

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confidence: 99%

Phenoxodiol Increases Cisplatin Sensitivity in Ovarian Clear Cancer Cells Through XIAP Down-regulation and Autophagy Inhibition

Miyamoto

Takano

Aoyama

et al. 2018

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confidence: 99%

Phenoxodiol Increases Cisplatin Sensitivity in Ovarian Clear Cancer Cells Through XIAP Down-regulation and Autophagy Inhibition

Miyamoto

Takano

Aoyama

et al. 2018

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“…Interestingly, XIAP confers resistance to cancer therapy and cell survival (28,29). Notably, XIAP inhibitors have shown promising outcomes in cancer therapy, including acute myeloid leukemia (30). We found that XIAP was upregulated in the synovial tissues of patients with RA; this was inversely proportional to miR-431-5p levels.…”

Section: Discussionmentioning

confidence: 74%

miR-431-5p regulates cell proliferation and apoptosis in fibroblast-like synoviocytes in rheumatoid arthritis by targeting XIAP

Wang

Zhang²,

Yuan

et al. 2020

Preprint

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BackgroundmiR-431-5p is dysregulated in various cancers and plays an important function in the development of cancer. However, its role in fibroblast-like synoviocytes (FLSs) in patients with rheumatoid arthritis (RA) remains to be understood.MethodsQuantitative real-time polymerase chain reaction was used to detect the relative expression of miR-431-5p in synovial tissues and FLSs. Cell proliferation assays helped examine RA FLS proliferation. Flow cytometry was performed to determine apoptosis and cell cycle progression in RA FLSs. We used dual-luciferase assays to determine the correlation between miR-431-5p and its putative target, X-linked inhibitor of apoptosis (XIAP). Quantitative real-time PCR and western blotting were used to measure XIAP levels in synovial tissues and transfected RA FLSs.ResultsmiR-431-5p was downregulated in synovial tissues and FLSs of patients with RA. Upregulation of miR-431-5p prohibited cell proliferation and the G0/G1-to-S phase transition, but promoted apoptosis in RA FLSs; while miR-431-5p inhibition showed the opposite results. miR-431-5p directly targeted XIAP in RA FLSs, and reversely correlated with XIAP levels in synovial tissues. Notably, XIAP silencing partially restored the effects of miR-431-5p inhibition in RA FLSs.ConclusionmiR-431-5p regulates cell proliferation, apoptosis，and cell cycle of RA FLSs by targeting XIAP, suggesting its potential in the treatment of RA.

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“…It has been reported that XIAP expression is elevated in numerous types of cancer (18)(19)(20)(21). Thus, the downregulation of XIAP is recognized as a potential anticancer approach (22)(23)(24).…”

Section: Discussionmentioning

confidence: 99%

MicroRNA‑509‑3p inhibits cell proliferation and invasion via downregulation of X‑linked inhibitor of apoptosis in glioma

Liao

et al. 2017

Oncol Lett

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Abstract. Malignant glioma is an aggressive type of cancer. Increasing evidence has suggested that microRNAs (miRs) regulate gene expression post-transcriptionally to affect cancer development and progression. Aberrant expression of miR-509-3p has been reported in cancer studies. However, the expression and mechanism of its function in glioma remains unclear. The present study demonstrated that miR-509-3p was downregulated in glioma tissue samples relative to non-tumor tissues, and that low miR-509-3p expression was associated with a reduced overall survival time. Functional studies revealed that the overexpression of miR-509-3p inhibited cell proliferation, induced apoptosis and suppressed cell migration and invasion via negatively regulating the expression of X-linked inhibitor of apoptosis. The data therefore suggested that miR-509-3p serves an important role in the development and progression of glioma, implicating its possible application in clinical practice as a biomarker and a potential novel therapeutic target.

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XIAP inhibitors induce differentiation and impair clonogenic capacity of acute myeloid leukemia stem cells

Cited by 24 publications

References 33 publications

Phenoxodiol Increases Cisplatin Sensitivity in Ovarian Clear Cancer Cells Through XIAP Down-regulation and Autophagy Inhibition

Phenoxodiol Increases Cisplatin Sensitivity in Ovarian Clear Cancer Cells Through XIAP Down-regulation and Autophagy Inhibition

miR-431-5p regulates cell proliferation and apoptosis in fibroblast-like synoviocytes in rheumatoid arthritis by targeting XIAP

MicroRNA‑509‑3p inhibits cell proliferation and invasion via downregulation of X‑linked inhibitor of apoptosis in glioma

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