2019
DOI: 10.1016/j.biopha.2019.109124
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Xin-Ji-Er-Kang ameliorates kidney injury following myocardial infarction by inhibiting oxidative stress via Nrf2/HO-1 pathway in rats

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Cited by 13 publications
(5 citation statements)
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“…Nrf2, which is normally coupled to Keap1 and is confined to the cytoplasm, separates from it in times of oxidative stress and relocates to the nucleus. In the nucleus, Nrf2 binds to the antioxidant response elements (ARE) and affects the gene expression of antioxidant and detoxifying enzymes [ 53 , 54 , 55 ]. One of the important enzymes is the phase II detoxification enzymes such as HO-1 (downstream enzyme), SOD, CAT, and GPx, which play an important role in protecting the kidney against oxidative stress and inflammation.…”
Section: Discussionmentioning
confidence: 99%
“…Nrf2, which is normally coupled to Keap1 and is confined to the cytoplasm, separates from it in times of oxidative stress and relocates to the nucleus. In the nucleus, Nrf2 binds to the antioxidant response elements (ARE) and affects the gene expression of antioxidant and detoxifying enzymes [ 53 , 54 , 55 ]. One of the important enzymes is the phase II detoxification enzymes such as HO-1 (downstream enzyme), SOD, CAT, and GPx, which play an important role in protecting the kidney against oxidative stress and inflammation.…”
Section: Discussionmentioning
confidence: 99%
“…According to Lian et al, in addition to downregulating the expression of several inflammatory factors and activating apoptosis-related proteins, MI model of rats having progressive nephropathy activate the renin-angiotensin-aldosterone system (RAAS), which is simultaneously connected with the defective Nrf2 pathway [42]. Hence, restoration of Nrf2 may have a positive influence on the RAAS.…”
Section: Myocardial Infarction (Mi)mentioning
confidence: 99%
“…[37] Rheumatic heart disease (RHD) Inhibits signal transducer [39] Cardiac tumors Regulates antioxidant defense enzymes and counteracts oxidative stress [40] Reduces toxicity with sulforaphane [41] Myocardial infarction (MI) Involved the renin-angiotensin-aldosterone system [42] Upgrades antioxidant genes [43] Myocardial ischemia reperfusion injury (MIRI)…”
Section: Viral Myocarditismentioning
confidence: 99%
“…The therapeutic effect of Radix Scrophulariae on SHr can be attributed to the suppression of the raS through the inhibition of the extracellular regulated protein kinase 1/2, c-Jun n-terminal kinase and p38 MaPK pathways (58). Xin-Ji-er-Kang can inhibit oxidative stress by affecting the raS, and can improve renal injury after myocardial infarction in rats (59). in addition, all herbal medicines that contain flavonoids, terpenoids, saponins and alkaloids are able to inhibit the raS (16).…”
Section: Mechanism Of Herbal Medicine In the Treatment Of Hypertensive Nephropathymentioning
confidence: 99%