Xinkeshu for coronary heart disease complicated with anxiety or depression: A meta-analysis of randomized controlled trials

Liu, Qian; Wang, Mengxi; Wang, Haiyan; Xie, Haiyang; Han, Jianda; Chen, Jiandong; Yu, Peng; Shen, Le; Li, Yehui; Tian, Ruina; Chen, Xiaohu

doi:10.1016/j.jep.2023.116486

Cited by 6 publications

(2 citation statements)

References 11 publications

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“…Atherosclerotic plaque consists of fat, cholesterol, blood cells, and fiber (Björnson et al, 2023). This plaque can harden, narrowing blood vessels, and even rupture, forming blood clots that can block blood flow to the heart muscle (Liu et al, 2023).…”

Section: Introductionmentioning

confidence: 99%

The Influence of Anxiety, Self-Efficacy, and Quality of Life in Coronary Heart Disease Patients

Koto,

Panduragan,

Poddar

et al. 2024

MJN

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Coronary heart disease (CHD) is a serious public health problem and requires an in-depth understanding of the factors that influence it, including anxiety and self-efficacy. The aim of the research was to determine the effect of anxiety and self-efficacy on the quality of life of coronary heart disease patients. Methods:The type of research used is correlation analysis with a cross-sectional approach. The population in the study was 70 patients with coronary heart disease at a heart hospital in Indonesia. The collection technique used total sampling, so the total sample consisted of 70 respondents. The research instrument used was the Depression Anxiety Stress Scales (DASS)21, General Self-Efficacy Scale, and Medical Outcomes. Study Short Form 36. Results:The results of statistical tests for each independent variable have a partial effect on the dependent variable. The significance value for the anxiety variable is 0.034, and self-efficacy is 0.001. Simultaneous test results obtained a sig value of 0.002, meaning that anxiety and self-efficacy influence the quality of life of patients with coronary heart disease. Conclusions:Patients with lower levels of anxiety tend to have a better quality of life. Ahigh level of self-efficacy is positively correlated with a better quality of life in coronary heart disease patients. The results of this study can provide a basis for designing more effective clinical interventions, such as stress management programs or self-empowerment programs, to improve the quality of life of coronary heart disease patients.

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Section: Introductionmentioning

confidence: 99%

The Influence of Anxiety, Self-Efficacy, and Quality of Life in Coronary Heart Disease Patients

Koto,

Panduragan,

Poddar

et al. 2024

MJN

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“…Based on available clinical evidence, traditional Chinese medicine is increasingly recognized for its significant role in the treatment of CHD and its complications ( Liu et al, 2022 ; Liu et al, 2023 ; Shen et al, 2023 ; Tao et al, 2023 ). Shuxuening injection (SXNI), a sterile preparation from folium Ginkgo [Yinxingye, Ginkgo biloba L.], is an botanical drug injection approved by the Chinese State Food and Drug Administration.…”

Section: Introductionmentioning

confidence: 99%

Effectiveness of Shuxuening injection in coronary heart disease: a systematic review and meta-analysis

Shi,

Sun,

et al. 2023

Front. Pharmacol.

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Background: Coronary heart disease (CHD) poses a serious threat to public health, and the current medical management still faces significant challenges. Reliable evidence on the efficacy of Shuxuening injection (SXNI) in CHD is still lacking, even though it is widely used in China.Purpose: To evaluate the efficacy of SXNI combination therapy in treating CHD.Methods: A systematic search of eight databases was conducted to identify relevant randomized controlled trials (RCTs) from the inception of each database until June 2023. ROB 2.0, RevMan 5.4, and Stata 15.1 were used for quality evaluation and data analysis. The Grading of Recommendation, Assessment, Development, and Evaluation (GRADE) approach was used to evaluate the quality of evidence.Results: A total of 3,779 participants from 39 studies were included. The results showed SXNI combination therapy increased the clinical efficacy and decreased the frequency and duration of angina. Furthermore, SXNI combination therapy improved cardiac function of patients by decreasing LVEDD, and increased CI, CO, and LVEF. It also improved blood lipid profiles by increasing HDL, decreasing TC, TG, and LDL. The thrombosis factors of patients were also improved by decreasing FIB, PV, HCT, and HS. Moreover, SXNI combination therapy was superior to the conventional treatment in improving CRP levels, increasing ECG efficacy and BNP. However, due to the limited safety information, reliable safety conclusions could not be drawn. Furthermore, the levels of evidence ranged from very low to moderate due to publication bias and heterogeneity.Conclusion: SXNI can effectively improve angina symptoms, clinical efficacy, cardiac function, blood lipid indicators, and thrombosis factors of patients with CHD. However, more multi-center and large-sample studies are needed to confirm the conclusions due to the limitations of this study.Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?RecordID=399606; Identifier: CRD42023433292.

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Effect of traditional Chinese medicine on metabolism disturbance in ischemic heart diseases

Wang,

Song,

et al. 2024

Journal of Ethnopharmacology

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Xinkeshu for coronary heart disease complicated with anxiety or depression: A meta-analysis of randomized controlled trials

Cited by 6 publications

References 11 publications

The Influence of Anxiety, Self-Efficacy, and Quality of Life in Coronary Heart Disease Patients

The Influence of Anxiety, Self-Efficacy, and Quality of Life in Coronary Heart Disease Patients

Effectiveness of Shuxuening injection in coronary heart disease: a systematic review and meta-analysis

Effect of traditional Chinese medicine on metabolism disturbance in ischemic heart diseases

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