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doi:10.13040/ijpsr.0975-8232.3(1).1-14

Cited by 2 publications

(2 citation statements)

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“…Antibiotics are available with different types, but most of them can be classified into 6 groups, such as: Penicillins, Cephalosporin; Aminoglycosides; Tetracyclines; Macrolides; Fluoroquinolone etc. There are series of drugs available with each groups and every antibiotic has its own criteria, thus, Chemical structure could be a great option to classify the Antibiotics 1,2 . Cephalosporins antibiotic have unique structure (Figure 1) with a common β -lactam ring that act to hinder Cell wall synthesis of the bacteria 3 .…”

Section: Introductionmentioning

confidence: 99%

“…Analytical HPLC method for Environmental water samples is available with a single Cephalosporin group 5,26 or a multiple Cephalosporin group like 3,27 which have determined mostly 06 (six) Cephalosporin drugs. By evaluating all relevant literature it is found that very recently in 2021, maximum 08 (Eight) Cephalosporin molecules has been detected and quantified in Pharmaceutical formulation through a HPLC method 1,22 .…”

Section: Introductionmentioning

confidence: 99%

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Simultaneous Determination of 11 Commonly used Cephalosporin Antibiotics Residue by High Performance Liquid Chromatography - Diode Array Detectors in Pharmaceutical Waste Water - A Tool for Controlling One of the Source of Antibiotic Resistance

Ullah,

Rana,

Hossain

2023

JOPCR

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11 commonly used Cephalosporin drugs from 1st, 2nd & 3rd Generation in wastewater from Cephalosporin Antibiotics Manufacturing plant is developed, validated and proposed for routine analysis of wastewater collected from waste water pre-treatment plant (wwptp). The determined residues included the routinely manufactured cephalosporin drugs for the treatment as β-Lactams Antibiotic drugs like Cefepime, Cefadroxil, Ceftazidime, Cephradine, Cefaclor, Cefotaxime, Ceftibuten, Ceftriaxone, Cefixime, Cefuroxime Axetil and Cefpodoxime proxetil. A gradient program was developed with Xterra RP-18 (250 cm x 4.6 mm, 5 µm) column as stationary phase. All cephalosporin molecules were selective and separated with a 0.2 M Tetra-butyl Ammonium Hydroxide (TBAH) buffer and Acetonitrile in the ratio of 85:15 V/V (Solution-A) and 25:75 V/V (Solution-B), pH 6.8 was adjusted with O-phosphoric acid into the buffer solution as the mobile phase at flow of 1.2 mL min- 1 with a UV detection at 254 nm using DAD. All peaks eluted within 60 minutes gradient run. The system suitability parameters such as theoretical plate count, tailing and resolution between the closest peaks were within the limit. The method was validated following all criteria regarding ICH (Q2) guidelines. Calibrations were linear over the concentration range of 0.5–150 µg mL-1 as indicated by correlation coefficient (r) of 0.999. The developed method can be the tool for determining the Cephalosporins residue as routine quantitative analysis of waste water discharged from the Antibiotic manufacturing plant. Keywords: Cephalosporins, Waste water, Method validation, Antibiotic Resistance, Antibiotic manufacturing plant

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Section: Introductionmentioning

confidence: 99%