2012
DOI: 10.1002/gepi.21638
|View full text |Cite
|
Sign up to set email alerts
|

XM: Association Testing on the X‐Chromosome in Case‐Control Samples With Related Individuals

Abstract: Genetic variants on the X-chromosome could potentially play an important role in some complex traits. However, development of methods for detecting association with X-linked markers has lagged behind that for autosomal markers. We propose methods for case-control association testing with X-chromosome markers in samples with related individuals. Our method, XM, appropriately adjusts for both correlation among relatives and male-female allele copy number differences. Features of XM include: (1) it is applicable … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

0
35
0

Year Published

2013
2013
2019
2019

Publication Types

Select...
6

Relationship

0
6

Authors

Journals

citations
Cited by 28 publications
(35 citation statements)
references
References 34 publications
0
35
0
Order By: Relevance
“…Finally, similar to Thornton et al. [], we define the diagonal terms to be Ωii=1+hi for females, where hi is the inbreeding coefficients for females based on pedigree relationships, and Ωii=2 for males regardless of inbred.…”
Section: Methodsmentioning
confidence: 99%
“…Finally, similar to Thornton et al. [], we define the diagonal terms to be Ωii=1+hi for females, where hi is the inbreeding coefficients for females based on pedigree relationships, and Ωii=2 for males regardless of inbred.…”
Section: Methodsmentioning
confidence: 99%
“…Association testing in the GFR data set was performed on Martingale residuals for AAO of AD using the W QLS test statistic (Bourgain et al , 2003) implemented in QM_QXM (Thornton & Mcpeek, 2007, Thornton et al , 2012) using the Hardy-Weinberg variance estimator. AAO of AD was adjusted for the count of APOE ε2, APOE ε4, and PSEN2 N141I alleles using a Cox proportional hazards model.…”
Section: Methodsmentioning
confidence: 99%
“…We assume that h ij is an inbreeding coefficient for an individual j in a family i , and thus if an individual j is a male, h ij becomes 0. π ij,i′j′ is a kinship coefficient between an individual j in a family i and an individual j′ in a family i′ . It should be noted that π ij,i′j′ is a function of gender, and can be deductively calculated [Thornton et al., ]. If i and i′ are different, π ij,i′j′ becomes 0.…”
Section: Methodsmentioning
confidence: 99%