XPA-210: a new proliferation marker determines locally advanced prostate cancer and is a predictor of biochemical recurrence

Aufderklamm, Stefan; Hennenlotter, Jörg; Todenhoefer, Tilman; Gakis, Georgios; Schilling, David; Vogel, U.; Kuehs, Ursula; Dlugosch, J.; Knapp, Judith; Merseburger, Axel S.; Gerber, Valentina; Ordelheide, Anna; Hevler, Joachim; Stenzl, Arnulf; Schwentner, Christian

doi:10.1007/s00345-011-0768-y

Cited by 11 publications

(16 citation statements)

References 18 publications

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“…A basic study on the expression of TK1 and Ki-67 demonstrated activated G1 cells to show higher TK1 expression compared with Ki-67 [11]. A highly specific TK1 monoclonal antibody developed by our laboratory has been used to assess the proliferation rate of benign, pre-malignant and malignant cells in breast [12] and prostate lesions [13,14]. TK1 was also more sensitive than Ki-67 in cancer patients with prostate [13] and ovary [15] carcinomas.…”

Section: Introductionmentioning

confidence: 99%

Nuclear TK1 expression is an independent prognostic factor for survival in pre-malignant and malignant lesions of the cervix

Chen

et al. 2013

BMC Cancer

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BackgroundThymidine kinase 1 (TK1) is a proliferation biomarker that has been found useful for prognostication in cancer patients. Here we investigate for the first time the use of TK1 expression as a prognostic factor for patients with premalignant and malignant lesions of the uterine cervix.MethodsTK1 expression was determined by immunohistochemistry in cervical lesions (cervical intraepithelial neoplasia (CIN), n = 216; invasive cervical carcinoma, n = 84). TK1 and Ki-67 expressions and pathological/FIGO stages and age were correlated with 5-year survival by Kaplan-Meier, log rank and COX hazard uni- and multivariate analyses.ResultsTK1 labeling index (LI) was significantly correlated with CIN grades and invasive cervical carcinoma stages, while TK1 labeling intensity was only correlated to CIN grades. TK1 LI was significantly higher compared with Ki-67 LI. TK1 LI correlated significantly to 5-year survival in patients with invasive cervical carcinoma, particularly nuclear TK1 LI. In a multivariate analysis, nuclear TK1 expression was independent prognostic factor in patients with in situ/invasive cervical carcinoma or in invasive cervical carcinoma alone. Interestingly, in invasive cervical carcinoma patients with advanced tumors, nuclear TK1 expression could identify patients with significantly better survival rates (80%), while Ki-67 could not.ConclusionsNuclear TK1 expression in early grade CIN predicts risk for progression to malignancy. Nuclear TK1 expression is also a prognostic factor for treatment outcome, particularly in patients with advanced cervical carcinomas. Nuclear TK1 expression is more useful than Ki-67 and pathological/FIGO stages.

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Section: Introductionmentioning

confidence: 99%

Nuclear TK1 expression is an independent prognostic factor for survival in pre-malignant and malignant lesions of the cervix

Chen

et al. 2013

BMC Cancer

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“…Among these, thymidine kinase 1 (TK1), a cellular enzyme involved in a salvage pathway for DNA synthesis, has attracted interest. TK1 is located at chromosome 17q25, is exclusively expressed in the cytoplasm of dividing cells and is absent in resting cells (4)(5)(6)(7). TK1 activity increases during the G1̸S phase and decreases through the G2̸mitosis phase (8)(9)(10).…”

Section: Introductionmentioning

confidence: 99%

Thymidine kinase 1 as a diagnostic tumor marker is of moderate value in cancer patients: A meta-analysis

et al. 2013

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Abstract. Thymidine kinase 1 (TK1) is an enzyme involved in nucleic acid synthesis and is therefore considered to be an important tumor proliferation marker. The aim of the present study was to determine the diagnostic role of TK1 measurement in cancer. An extensive electronic search was performed in PubMed, EMBASE and the Cochrane Library using the keywords 'thymidine kinase 1' and 'tumor' and synonyms. This study was conducted as part of a project to establish evidence-based guidelines for the diagnosis and treatment of cancer. A total of 453 abstracts were screened, after which the full text of 40 studies were selected for further investigation, including screening of the references cited by studies in the original search. Fifteen studies were enrolled following full-text evaluation. The areas under the receiver operating characteristic curves for the radioenzymatic assay (REA), the chemiluminescence immunoassay (CLIA) and the total were 0.88, 0.75 and 0.8, respectively. These results were all between <0.9 and >0.7, which suggested a moderate diagnostic efficacy. The positive likelihood ratio of the CLIA method was the highest (10.229), which demonstrated that CLIA exhibited a satisfactory specificity in tumor diagnosis. However, TK1 as a single diagnostic tumor marker was not of significant value and the combination of more tumor markers in the diagnosis of tumors may be preferable.

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“…С учетом того, что ТК-1 проявляет себя как мар-кер клеточной пролиферации и практически не об-наруживается в неделящихся клетках, исследования по изучению степени ее экспрессии нашли свое при-менение в области онкологии [53][54][55][56][57][58][59][60][61][62][63][64][65][66]. В этих работах была сопоставлена экспрессия ТК-1 и 2 других широ-ко используемых маркеров клеточной пролиферации (Ki-67 и PCNA (proliferating cell nuclear antigen)) [41] при ряде солидных злокачественных новообразований (колоректальном раке, раке почки, яичников, шейки матки, предстательной и молочной желез), некоторых доброкачественных опухолях и предраковых состояни-ях, а также в нормальных тканях [53][54][55][56][57][58][59][60][61][62][63][64][65][66].…”

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“…В этих работах была сопоставлена экспрессия ТК-1 и 2 других широ-ко используемых маркеров клеточной пролиферации (Ki-67 и PCNA (proliferating cell nuclear antigen)) [41] при ряде солидных злокачественных новообразований (колоректальном раке, раке почки, яичников, шейки матки, предстательной и молочной желез), некоторых доброкачественных опухолях и предраковых состояни-ях, а также в нормальных тканях [53][54][55][56][57][58][59][60][61][62][63][64][65][66].…”

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“…При исследова-нии экспрессии ХРА-210 установлено, что интенсив-ность окрашивания клеток коррелировала со стадией опухолевого процесса и оценкой злокачественности по шкале Глисона. Кроме того, высокий уровень экс-прессии ХРА-210 коррелировал с коротким временем как до развития биохимического рецидива заболева-ния, так и до визуализации метастазов [66].…”

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The thymidine kinase-1 as a potential tumor marker: structure, function, activity in normal and malignant tissues

Сергеева¹,

Parilova²,

Маршутина³

et al. 2017

Usp. mol. onkol

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XPA-210: a new proliferation marker determines locally advanced prostate cancer and is a predictor of biochemical recurrence

Cited by 11 publications

References 18 publications

Nuclear TK1 expression is an independent prognostic factor for survival in pre-malignant and malignant lesions of the cervix

Nuclear TK1 expression is an independent prognostic factor for survival in pre-malignant and malignant lesions of the cervix

Thymidine kinase 1 as a diagnostic tumor marker is of moderate value in cancer patients: A meta-analysis

The thymidine kinase-1 as a potential tumor marker: structure, function, activity in normal and malignant tissues

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