Xpert® BC detection as a diagnostic tool in upper urinary tract urothelial carcinoma: Preliminary results

D’Elia, Carolina; Trenti, Emanuela; Folchini, D.M.; Pycha, Stefan; Mian, Christine; Schwienbacher, Christine; Hanspeter, Esther; Pycha, A.

doi:10.1016/s0302-2838(21)01152-0

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Clinical Presentation and Diagnosis2

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2024

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“…Urine cytology is less sensitive for UTUC than for bladder cancer and should only be performed selectively for the affected/suspected upper tract 13 . Further comparative research into the use of urine biomarkers is needed, as these may obviate the need for a diagnostic ureteroscopy to establish a diagnosis of UTUC 14 . For example, the Xpert bladder cancer detection mRNA‐based urinary biomarker was compared with urinary cytology and Urovysion (fluorescence in situ hybridisation test) in patients suspected of having UTUC.…”

Section: Clinical Presentation and Diagnosismentioning

confidence: 99%

“…For example, the Xpert bladder cancer detection mRNA‐based urinary biomarker was compared with urinary cytology and Urovysion (fluorescence in situ hybridisation test) in patients suspected of having UTUC. The respective overall sensitivity and specificity was Xpert (100%, 17%), cytology (52%, 95%) and Urovysion (93%, 85%) 14 . At present their sensitivity and specificity is promising, but not yet ready for ‘prime time’.…”

Section: Clinical Presentation and Diagnosismentioning

confidence: 99%

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