XRCC3 T241M polymorphism and melanoma skin cancer risk: A meta-analysis

Abstract

Abstract. Although the T241M polymorphism in the X-ray cross-complementing group 3 (XRCC3) gene has been implicated in the pathogenesis of melanoma, the results have been inconsistent. In this study, a meta-analysis was performed to assess the association of XRCC3 T241M polymorphism with melanoma. Published literature from PubMed and Embase databases was retrieved. The pooled odds ratio (OR) with 95% confidence interval (CI) was calculated using fixed-or random-effects models. A total of six case-control studies containing 2,133 patients and 3,141 controls were enrolled into this meta-analysis. In a combined analysis, the results revealed no significant association between XRCC3 T241M polymorphism and melanoma risk in the overall population. In the subgroup analysis by ethnicity, no significant associations between the XRCC3 T241M polymorphism and melanoma risk were identified in Caucasians. However, when the analyses were restricted to three larger studies (n>500 cases), a significant association was noted with melanoma (TT vs. MT: OR=1.20, 95% CI=1.04-1.38; dominant model: OR=0.86, 95% CI=0.75-0.98). In conclusion, the meta-analysis results suggest that the XRCC3 T241M polymorphism was associated with risk of melanoma. Further large and well-designed studies are needed to confirm this conclusion.

WITHDRAWN: Association between XRCC3 rs861539(Thr241Met) polymorphism and thyroid cancer risk (a Meta-analysis)

“…In the past decade, Numerous studies have investigated the potential biological signi cance of the XRCC-3 rs861539(Thr241Met) [28][29][30][31] , and it has been implicated as a causative risk factor for the development of different types of malignancies. The malignancy types included breast cancer [7,32,33] , lung cancer [34] , osteosarcoma [35] , melanoma [36] , thyroid cancer [14,16] . However, the correlation between XRCC3 rs861539 polymorphism and thyroid cancer risk still remained controversial [9,13,16,17] .…”

Centenarian Exomes as a Tool for Evaluating the Clinical Relevance of Germline Tumor Suppressor Mutations

“…14 Also, a Belgian study found that the T allele of this variant is not a risk allele for breast cancer. 15 A meta-analysis 16 concludes that this variant is the risk factor for melanoma, but the association is not significant in Caucasians. There was no significant association found between this polymorphism and lung cancer risk 17 in a population from northern Spain and prostate cancer in north Indian population.…”

A 3′ untranslated region polymorphism rs2304277 in the DNA repair pathway gene OGG1 is a novel risk modulator for urothelial bladder carcinoma

“…These discrepancies regarding the role of rs861539 in UBC susceptibility as well as the functional effects of this change on the DNA repair pathway suggest the need for more detailed studies to elucidate its role. Moreover, the putative effect of this polymorphism may be influenced by gene–gene or gene–environment interactions (Fan et al., ), which is also needed to be studied in greater detail.…”

“…Metabolites of carcinogenic and genotoxic agents are excreted via urine, resulting in direct exposure of the urothelial cells to these compounds, thus rendering bladder urothelium vulnerable to DNA damage. However, cells are equipped to counteract this damage and maintain genomic integrity via the DNA repair pathways such as base excision repair (BER), nucleotide excision repair (NER), and double‐strand break repair (DSBR) (Sedelnikova et al., ; Fan, Fan, Kang, & Zhao, ; Das et al., ). DSBR is executed by two distinct mechanisms: homologous recombination (HR) and nonhomologous end‐joining repair (Zhi et al., ).…”