XXIII.—On the hydride of aceto-salicyl

Abstract

IN Home considerations on the formation of coumarin by means of the hydride of sodium-salicyl and acetic anhydride, which I had the honour of laying before the Society only a short time since,* I mentioned that the formation of this body appeared to be the result of two distinct reactions-the first consisting in the replacement of an equivalent of hydrogen in the hydride of salicyl by acetyl-the second in the removal of a molecule of water fiom this acetylic derivative. I also stated that I had succeeded in obtaining the body resulting fiom the first reaction, and which I termed the hydride of aceto-salicyl. The present * Page 60 of thie volume.

Synthesis, characterization and electrochemical properties of tetra 7-oxy-3-biphenylcoumarin substituted metal-free, zinc(II), cobalt(II) and indium(III) phthalocyanines

“…7-Hydroxy-3-biphenylcoumarin (1) was synthesized by the Perkin condensation of 4-biphenylacetic acid with 2,4-dihydroxybenzaldehyde [39]. The intermediates; 7-(2,3- (2) All the compounds (4-11) were also analyzed using elemental analysis and mass spectra.…”

Synthesis and biological evaluation of thiophosphate tricyclic coumarin derivatives as steroid sulfatase inhibitors

“…Many convenient synthetic methods have been described, including Pechmann [7], Perkin [8], Knoevenagel condensation [9], Reformatsky [10], and Wittig reactions [11]. Recent reports of the synthesis of coumarin derivatives include the use of metal triflates in qFriedel-Crafts alkenylations of aromatic compounds with various alkyl-and aryl-substituted alkynes [12], hydroarylation of arylpropionic acid methyl esters having a methoxymethyl acetal (MOM) protected hydroxy group with various arylboronic acids in the presence of a catalytic amount of CuOAc [13], reaction of substituted phenyl acetic acids and substituted 2-hydroxy benzaldehydes in the presence of cyanuric chloride (2,4,6-trichloro-1,3, 5-triazine) and N-methyl morpholine [14], palladium-catalyzed oxidative cyclocarbonylation of 2-vinylphenols [15], condensation of aroylketene dithioacetals, and 2-hydroxybenzaldehydes in the presence of a catalytic amount of piperidine [16], or reaction of 2-hydroxybenzaldehydes, triphenylphosphine, and dialkyl acetylenedicarboxylate via vinyltriphenylphosphonium salt-mediated aromatic electrophilic substitution [17].…”

Discovery of New Fluorescent Dyes: Targeted Synthesis or Combinatorial Approach?

“…As shown in Fig. 2a, he made a coumarin by treating the sodium salt of ortho-hydroxybenzaldehyde (also known as salicylic aldehyde) with acetic anhydride [6][7][8]. Since the report of famous coumarin synthesis, many other novel methods have been developed by Pechmann [9][10][11], Claisen [12], Knoevenagel [13,14], Reformatsky [15], and Wittig [16] for the synthesis of pyrone-ring moieties in coumarins.…”