XXXII The Temporal Bone in Leukemia Histological Studies

Abstract

Deafness in leukemia was first described by Donne! and by Vidal. 2 Politzer" was the first to do histological studies on the temporal bones of a patient with deafness associated with leukemia. Subsequent cases were reported by Steinbrugge," Wagenhauser" and Schwabach.6 The latter studied histologically five cases of his own and reviewed ten cases from the literature. He stated that two of his own five cases had clinical ear symptoms without pathological changes in the temporal bones. Alexander,' after having studied 15 cases histologically, stressed the very high percentage of involvement of the middle and inner ear in leukemia. One other case was reported by Nishio."Alexander's? observations were confirmed by Druss" who studied 148 patients clinically and four temporal bones histologically. He found clinical involvement of the ear in 16.5 percent of the patients. He observed the following otologic signs: 1) ulceration of the skin of the external auditory meatus with and without hemorrhage, 2) hemorrhage into the middle ear and the mastoid with and without infection, and 4) mixed hearing loss and facial nerve palsy. Druss" observed that pathological findings in the temporal bones, such as infiltration of the middle ear mucosa, were not always associated with clinical symptoms. Other cases were histologically examined by Cawthorne;'? Hallpike," de Stefani'" and Schuknecht et aP3 Shambrom and Finch!' found otologic symptoms in 32 of 100

Otological Diseases in Patients with Chronic Myeloid Leukemia

“…The prevalence obtained is higher than what was reported locally by Joseph and Durosinmi [5] and Druss [2]. Comparable higher prevalence of hearing loss were reported by [4], [8] and [3] but these studies included all forms of leukemia.…”

Incidence of non-infectious ‘acute mastoiditis’ in children

“…However, a clinical presentation resembling acute mastoiditis is uncommon. [11][12][13] Our study revealed a small but significant percentage of children (2.7 per cent) with a clinical presentation of acute mastoiditis that subsequently proved to be of noninfectious origin. Therefore, otologists and paediatricians should bear in mind a non-infectious pathology as a rare but possible cause of an acute mastoiditis like clinical presentation in young patients.…”

Sudden Deafness – A Critical Evaluation of Pathogenesis and ‘Cure’

“…Acute hemorrhage within the cochlea is probably very rare but is described in the literature in combination with leukemia [57]. Direct trauma to the cochlea with or without fracture may give the same picture.…”