Ann Otol Rhinol Laryngol

1953

DOI: 10.1177/000348945306200206

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XXXIV The Clinical Significance of Keratosis of the Larynx as a Premalignant Lesion

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Cited by 46 publications

(18 citation statements)

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“…The first follow‐up studies of precancerous conditions of the larynx were published in the early 1950s and concerned CIS and keratosis, respectively 9, 10. Since then, several follow‐up studies on the long‐term risk of malignant progression in LMPLs have been reported.…”

Section: Discussionmentioning

confidence: 99%

Management of laryngeal premalignant lesions in the netherlands

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et al. 2010

The Laryngoscope

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There are significant differences in the management of LPMLs between otorhinolaryngologists at tertiary and secondary referral centers, depending on the location and histopathology of the lesions. Consensus on and development of guidelines concerning the management of LMPLs could be useful to optimize the diagnosis, treatment, and follow-up of these lesions.

“…The first follow‐up studies of precancerous conditions of the larynx were published in the early 1950s and concerned CIS and keratosis, respectively 9, 10. Since then, several follow‐up studies on the long‐term risk of malignant progression in LMPLs have been reported.…”

Section: Discussionmentioning

confidence: 99%

Management of laryngeal premalignant lesions in the netherlands

¹

,

²

,

³

et al. 2010

The Laryngoscope

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There are significant differences in the management of LPMLs between otorhinolaryngologists at tertiary and secondary referral centers, depending on the location and histopathology of the lesions. Consensus on and development of guidelines concerning the management of LMPLs could be useful to optimize the diagnosis, treatment, and follow-up of these lesions.

“…Altmann et al and Putney et al reported the first follow-up studies of precancerous conditions of the larynx; carcinoma in situ and keratosis, respectively. [ 42 , 43 ] Since then several follow-up studies concerning the natural evolution and long-term risk of malignant progression in intraepithelial lesions have been reported. In these studies, usually no distinction between natural evolution without treatment (prognostic value) and predictive value (response to treatment) is made.…”

Section: Prognostic and Predictive Valuementioning

confidence: 99%

Grading systems in head and neck dysplasia: their prognostic value, weaknesses and utility

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2009

Head Neck Oncol

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BackgroundGrading of dysplasia, including head and neck lesions, continues to be a hotly debated subject. It is subjective and lacks intra- and inter-observer reproducibility due to the insufficiency of validated morphological criteria and the biological nature of dysplasia. Moreover, due to the absence of a consensus, several systems are currently employed.ObjectivesThe aims of this review are to:1) Highlight the significance of dysplasia and the importance of a valid method for assessing precursor lesions of the head and neck.2) Review the different histopathological classification systems for grading intraepithelial lesions of the head and neck.3) Discuss and review quality requirements for these grading systems.ConclusionRegarding the different classification systems, data concerning the WHO classification system are the most available in current literature. There is no simple relationship or overlapping between the classification systems. Further studies should be done to see whether other systems have advantages above the current WHO system and to discover indications that could lead to an universal classification system for intraepithelial lesions of the head and neck.

“…During recent decades, various aspects of laryngeal carcinogenesis have been intensively studied, including the aetiology, histological classification, treatment, frequency of malignant transformation and predictive factors. Many researchers have provided meticulous analyses of histological classifications of SILs in relation to their biological behaviour 2–4,6–27 . These analyses have been recently further supplemented by molecular genetic investigations trying to elucidate the pathogenic mechanisms of SCC development, and to improve the prognostic evaluation of SILs 1,28–51 …”

Section: Introductionmentioning

confidence: 99%

Current review on squamous intraepithelial lesions of the larynx

Gale¹,

et al. 2009

Histopathology

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Squamous intraepithelial lesions (SILs) of the larynx, clinically usually defined as leukoplakia and chronic laryngitis, have remained the main controversial topic in laryngeal pathology for decades as regards classification, histological diagnosis and treatment. SILs are caused by smoking and alcohol abuse. There is also mounting evidence that gastroesophageal reflux is a potential aetiological factor. Human papillomavirus infection seems to play little if any role in laryngeal carcinogenesis. Histological classification of SILs is the central disputed aspect of these lesions. There are as yet no generally accepted criteria for histological grading of laryngeal SILs. Three currently used classifications of SILs are reviewed here: the dysplasia system, the Ljubljana classification and the binary system of squamous intraepithelial neoplasia. One of the most important issues of SILs is the risk of malignant transformation. Data in the literature are controversial because of inconsistent use of morphological criteria in different classifications. It is often difficult for clinicians to agree on the most appropriate therapeutic option for a particular grade of SIL that has been diagnosed. Transition from normal epithelium to SILs and squamous cell carcinoma is related to progressive accumulation of genetic changes leading to a clonal population of transformed epithelial cells. Despite extensive research into these genetic changes in laryngeal carcinogenesis, reliable genetic markers with diagnostic and prognostic value are still lacking.

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