<i>Xylella fastidiosa</i> is xylem-limited bacterium capable of infecting a wide range of host plants, resulting in Pierce's disease in grapevine, citrus variegated chlorosis, olive quick decline syndrome, peach phony disease, plum leaf scald, alfalfa dwarf, margin necrosis and leaf scorch affecting oleander, coffee, almond, pecan, mulberry, red maple, oak, and other types of cultivated and ornamental plants and forest trees. In the European Union, <i>X. fastidiosa</i> is listed as a quarantine organism. Since its first outbreak in the Apulia region of southern Italy in 2013 where it caused devastating disease on Olea europaea (called olive leaf scorch and quick decline), <i>X. fastidiosa</i> continued to spread and successfully established in some European countries (Corsica and PACA in France, Balearic Islands, Madrid and Comunitat Valenciana in Spain, and Porto in Portugal). The most recent data for Europe indicates that <i>X. fastidiosa</i> is present on 174 hosts, 25 of which were newly identified in 2021 (with further five hosts discovered in other parts of the world in the same year). From the six reported subspecies of <i>X. fastidiosa</i> worldwide, four have been recorded in European countries (<i>fastidiosa</i>, <i>multiplex</i>, <i>pauca</i>, and <i>sandyi</i>). Currently confirmed <i>X. fastidiosa</i> vector species are <i>Philaenus spumarius</i>, <i>Neophilaenus campestris</i>, and <i>Philaenus italosignus</i>, whereby only <i>P. spumarius</i> (which has been identified as the key vector in Apulia, Italy) is also present in Americas. <i>X. fastidiosa</i> control is currently based on pathogen-free propagation plant material, eradication, territory demarcation, and vector control, as well as use of resistant plant cultivars and bactericidal treatments.