Xylitol bioproduction: state-of-the-art, industrial paradigm shift, and opportunities for integrated biorefineries

Hernández-Pérez, Andrés Felipe; Arruda, Priscila Vaz de; Sene, Luciane; Silva, Sílvio Silvério da; Chandel, Anuj K.; Felipe, Maria das Graças de Almeida

doi:10.1080/07388551.2019.1640658

Cited by 115 publications

(78 citation statements)

References 122 publications

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“…Considering biodiesel as the only valuable product, is not economically feasible within the current low-cost petroleum market. As the number of value-added products increase, the economic feasibility of the production chain also increases, and will be even better if the possibility of generating electricity for self-consumption through the use of methane from waste materials from jatropha biomass is included under a biorefinery concept (Eastmond and Sacramento Rivero and Sweitz, 2018;Hernández-Pérez, et al, 2019).…”

Section: Liquid Biofuelsmentioning

confidence: 99%

“…This situation creates uncertainty for private investors, which explains why the use of biofuels in Mexico is almost non-existent (BP Global Group, 2013) and why initiatives must come from the government. Additionally, a policy of fiscal incentives (subsidies, taxes, regulatory policies) that support the industrialization of biofuels, similar to policies in the USA, Brazil, and the EU, is necessary to stimulate the use of bioethanol and biodiesel blends (Hernández-Pérez, et al, 2019;Su, Zhang and Su, 2015), especially when fossil fuel prices are low. With current technology, biofuels cannot compete with fossil fuel prices without subsidies or other federal support (Fiorese et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

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Biocombustibles y su potencial en el mercado energético mexicano

Paredes-Cervantes

Barahona-Pérez

Barroso-Tanoira

et al. 2020

Revista de Economía

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Debido a que los biocombustibles representan una opción satisfactoria de energía renovable para México, el objetivo de esta investigación fue explorar y describir el estado actual de las políticas de biocombustibles en este país, así como sugerir estrategias para incrementar su potencial en el mercado energético. El método se basó en una revisión de diferentes estudios y entrevistas a importantes productores y académicos expertos. Los resultados indican que el biogás es el biocombustible con el más alto potencial de desarrollo, seguido por el bioetanol, pero las oportunidades para el biodiesel son reducidas, principalmente debido a una insuficiente producción de materia prima. Se requiere una política de incentivos fiscales para mantener a los productores en el mercado.

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Section: Liquid Biofuelsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Biocombustibles y su potencial en el mercado energético mexicano

Paredes-Cervantes

Barahona-Pérez

Barroso-Tanoira

et al. 2020

Revista de Economía

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“…Furthermore, even using lignocellulose as raw material, is not an environmental‐friendly process. As an alternative, in recent years biotechnological production has been proposed from d ‐xylose present in hemicellulosic hydrolysates of agroindustry residues such as wheat straw, rice straw, palm, corn cobs, corn stalks, sugarcane bagasse, among others . Fermentation is carried out through microorganisms that reduce d ‐xylose to d ‐xylitol by the action of the enzyme xylose reductase .…”

Section: Introductionmentioning

confidence: 99%

Modeling of the xylitol production from sugarcane bagasse by immobilized cells

Dorantes‐Landa

Cocotle‐Ronzón

Morales-Cabrera

et al. 2020

J of Chemical Tech & Biotech

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BACKGROUND Xylitol is a polyalcohol widely used in the pharmaceutical, medicine and food industry because of its anti‐cariogenic properties and low caloric value, with a sweetness equal to sucrose. Xylitol can be produced chemically or through a biotechnological route, though the last alternative still does not reach the yields to satisfy the industrial needs. The biotechnological route is an important alternative for the valorization of agroindustrial waste rich in hemicellulosic sugars, such as cane sugar bagasse, rice straw, banana peel, among others. To reduce the experimental costs, mathematical modeling is useful for determining the fermentation operation conditions and to improve the overall process. RESULTS A dynamic mathematical model for the description of xylitol production from sugarcane bagasse by Candida guilliermondii cells entrapped was developed. For the description of the microbial growth rate, free and immobilized microorganisms situations were considered in the kinetic model, including mass transfer effects. Experimental data reported in the literature were used to validate the proposed model. Additionally, a parametric estimation by the Levenberg–Marquardt method and a parametric sensitivity analysis was also performed. CONCLUSION The best experimental fit was obtained when the effects of inhibition by substrates are included in the kinetic model reaching a global determination index R2 > 0.95. Furthermore, this proposed model allowed us to evaluate the restraints that are generated due to the internal and external mass transfer processes of the immobilized medium. The parametric sensitivity analysis demonstrated the optimal operation conditions where the xylitol production can be favored. © 2020 Society of Chemical Industry

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“…Among all the xylose derived value-added chemicals, xylitol production through biotechnological intervention has been one of the most studied product. Unlike conventional chemical route, xylitol production via microbial pathway is less energy-intensive, environmentally benign and offers numerous advantages such as reduced puri cation cost of xylose and direct use of biomass-derived mixed sugars [6,7]. Xylitol is recognised as one of the twelve most promising platform chemicals, owing to its transformation potential into value-added products such as xylaric acid, glycerol, lactic acid, ethylene glycol, propylene glycol and derivatives of hydroxyfurans.…”

Section: Introductionmentioning

confidence: 99%

Assessing the Potential of Newly Isolated Pichia Fermentans for Xylitol Production Using Non-Detoxified Xylose Rich Pre-Hydrolysate Derived from Sugarcane Bagasse

Prabhu

Bosakornranut

Amraoui

et al. 2020

Preprint

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Background: Integrated management of hemicellulosic fraction and its economical transformation to value-added products is the key driver towards sustainable second-generation biorefineries. In this aspect microbial cell factories are harnessed for sustainable production of biochemicals by valorising C5 and C6 sugars generated from agro-industrial waste. However, most of the strains can effectively consume C6 sugars but lacks pentose metabolism pathway. The effective utilization of both pentose and hexose sugars is key for economical biorefinery. Results: In the current study, the ability of a newly isolated xylose assimilating Pichia fermentans was explored for xylitol production. The wild type strain robustly grew on xylose and produced xylitol with >40% conversion yield. Mutagenesis with ethyl methanesulphonate (EMS) yielded seven mutants. The mutant obtained after 15 min exposure, exhibited best xylose bioconversion efficiency. This mutant under shake flask conditions produced maximum xylitol titre and yield of 34.0 g/L and 0.68 g/g, respectively. oweverHoHHHoHowever, under same conditions, the control wild type strain accumulated 27.0 g/L xylitol with a conversion yield of 0.45 g/g. Improved performance of the mutant was attributed to 34.6% activity enhancement in xylose reductase with simultaneous reduction of xylitol dehydrogenase activity by 22.9%. Later, the culture medium was optimized using statistical design and validated at shake flask and bioreactor level. Bioreactor studies affirmed the competence of mutant in xylitol accumulation. The xylitol titre and yield obtained with pure xylose were 98.9 g/L and 0.67 g/g, respectively while xylitol produced using non-detoxified xylose rich pre-hydrolysate from sugarcane bagasse was 79.0 g/L with an overall yield of 0.54 g/g. Conclusion: This study established the potential of P. fermentans in successfully valorising the hemicellulosic fraction for sustainable xylitol production.

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Xylitol bioproduction: state-of-the-art, industrial paradigm shift, and opportunities for integrated biorefineries

Cited by 115 publications

References 122 publications

Biocombustibles y su potencial en el mercado energético mexicano

Biocombustibles y su potencial en el mercado energético mexicano

Modeling of the xylitol production from sugarcane bagasse by immobilized cells

Assessing the Potential of Newly Isolated Pichia Fermentans for Xylitol Production Using Non-Detoxified Xylose Rich Pre-Hydrolysate Derived from Sugarcane Bagasse

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