Xyloglucan and Concanavalin A based dressings in the topical treatment of mice wound healing process

Arruda, Isabel R.S.; Souza, Marthyna Pessoa de; Soares, Paulo R.; Albuquerque, Priscilla Barbosa Sales de; Silva, Túlio D.; Medeiros, Paloma Lys de; Silva, Márcia V.; Correia, Maria T.S.; Vicente, A. A.; Carneiro-da-Cunha, Maria G.

doi:10.1016/j.carpta.2021.100136

Cited by 9 publications

(1 citation statement)

References 69 publications

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“…Furthermore, the circular epidermal wounds treated with tamarind seed extracts exhibited shorter healing periods than the control in ICR mice [15]. Thus, XG has been developed and fabricated for wound dressings [16][17][18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Formulation and Optimal Design of Dioscorea bulbifera and Honey-Loaded Gantrez®/Xyloglucan Hydrogel as Wound Healing Patches

et al. 2022

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Hydrogel patches are some of the most effective dressings for wound healing. In this study, the Gantrez® S-97 (Gan)/xyloglucan (XG) hydrogel patches were formulated by using a full central composite design (CCD). The optimized hydrogel patches consisted of 17.78% w/w of Gan and 0.1% w/w of XG. Honey and D. bulbifera extract were loaded in the Gan/XG hydrogel patches. The physical properties of the hydrogel patches, including water content, water absorption, rate of water vapor transmission, and mechanical properties, were examined. The D. bulbifera extract/honey-loaded patch exhibited a higher value of water absorption, tensile strength, and elongation than the honey-loaded patch and the unloaded patch, respectively. The biological activities of the patches were also investigated. All hydrogel patches protected wounds from external bacterial infection. The D. bulbifera extract/honey-loaded patch exhibited stronger antioxidant activity than the honey-loaded patch and the unloaded patch. Besides, all the hydrogel patches with concentrations of 0.5–2.5 mg/mL showed that they were nontoxic to fibroblast cells. The combination of D. bulbifera extract and honey in the patch affected fibroblast proliferation. In addition, all Gan/XG hydrogel patches significantly induced recovery of the scratch area. Therefore, the Gan/XG hydrogel patches could be candidates as wound dressings.

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