Xyloglucan for drug delivery applications

Pardeshi, Chandrakantsing V.; Kulkarni, Abhijeet D.; Belgamwar, Veena S.; Surana, Sanjay J.

doi:10.1016/b978-0-08-102194-1.00007-4

Cited by 10 publications

(8 citation statements)

References 103 publications

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“…Galactomannan is a polysaccharide composed of a β-1,4-D-mannose backbone with varying numbers of α-1,6 linked branches of a single α-D-galactose unit [57]. Xyloglucan is another polysaccharide, derived from tamarind seed, that has a β-1,4-D-glucan backbone substituted with α-1,6 linked side chains of α-D-xylose and α-1,2 linked β-D-galactosyl units to glucose residues [58]. We hypothesized that the hydrophilic character of these polysaccharides if successfully conjugated to CPP could result in an increase surface activity and possibly conformational changes of peptide structure, that would alter interfacial adsorptive and hydrophilicity, thus enhancing the antioxidant activity of CPP.…”

Section: Discussionmentioning

confidence: 99%

Antioxidant Properties of Casein Phosphopeptides (CPP) and Maillard-Type Conjugated Products

2020

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A casein phosphopeptide (CPP) fraction derived from tryptic hydrolysis of bovine casein was evaluated for antioxidant activity. Conjugations or mixtures of CPP with polysaccharide, galactomannan (Gal), or xyloglucan (Xyl) were prepared to evaluate potential enhancement of CPP antioxidant activity. The effect of calcium was also investigated. The CPP preparation alone was effective at scavenging hydroxyl radicals and sequestering Fe2+ to protect against Fenton reaction-induced deoxyribose oxidation in non-site-specific (up 63.3% inhibition) and site-specific (up 32.1% inhibition) binding assays, respectively. CPP also effectively quenched 2,2’-azinobis-3-ethylbenzothiazoline-6-sulfonic acid radicals (ABTS•+) to an extent of 67.6% scavenging in an aqueous system. In a soybean lecithin liposome system, CPP exhibited effective protection against peroxyl radical-induced liposomal peroxidation (38.3% of control in terms of rate of propagation). Conjugating CPP with Gal or Xyl polysaccharides using Maillard reaction conditions significantly reduced activity in the Fenton reaction-deoxyribose assays, while exhibiting no effect on the antioxidant activity of native CPP in both the ABTS and liposome assays, respectively. These results represent comparative antioxidant capacity of the native CPP and associated conjugates in phases that varied in relative hydrophilic and hydrophobic character. We conclude that CPP has the potential to act as both a primary and secondary antioxidant by displaying transition metal ion sequestering activity and free radical quenching activity. Improvements in antioxidant activity of CPP by Maillard-type conjugation with Xyl or Gal were relatively small and model-specific.

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Section: Discussionmentioning

confidence: 99%

Antioxidant Properties of Casein Phosphopeptides (CPP) and Maillard-Type Conjugated Products

2020

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“…Xyloglucan has been widely employed in the pharmaceutical business, such as drug delivery systems. A series of publications on xyloglucan-based drug carriers for biomedical purposes, including thermo-sensitive hydrogel and thermos-reversible hydrogel in situ, was published recently [ 70 ]. As a result, this polysaccharide has several uses and should be researched further by academia.…”

Section: Chemical Structure Of Polymeric Hydrogelsmentioning

confidence: 99%

New Challenges and Prospective Applications of Three-Dimensional Bioactive Polymeric Hydrogels in Oral and Craniofacial Tissue Engineering: A Narrative Review

et al. 2023

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Regenerative medicine, and dentistry offers enormous potential for enhancing treatment results and has been fueled by bioengineering breakthroughs over the previous few decades. Bioengineered tissues and constructing functional structures capable of healing, maintaining, and regenerating damaged tissues and organs have had a broad influence on medicine and dentistry. Approaches for combining bioinspired materials, cells, and therapeutic chemicals are critical in stimulating tissue regeneration or as medicinal systems. Because of its capacity to maintain an unique 3D form, offer physical stability for the cells in produced tissues, and replicate the native tissues, hydrogels have been utilized as one of the most frequent tissue engineering scaffolds during the last twenty years. Hydrogels’ high water content can provide an excellent conditions for cell viability as well as an architecture that mimics real tissues, bone, and cartilage. Hydrogels have been used to enable cell immobilization and growth factor application. This paper summarizes the features, structure, synthesis and production methods, uses, new challenges, and future prospects of bioactive polymeric hydrogels in dental and osseous tissue engineering of clinical, exploring, systematical and scientific applications.

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“…Hydrogels have been mainly centred on drug delivery [ 139 , 140 , 141 ], tissue engineering and environmental protection, and have demonstrated pH, ionic strength, media composition and organic-solvent-dependent behaviour. Thus, the removal of heavy metals such as Ni (II), Cu(II), Pb (II), Cd(II), Pd(II) and Zn(II) or sulfadimidine has been successfully achieved by these hydrogels [ 142 , 143 , 144 ].…”

Section: Lignocellulosic Materials For the Production Of Biofuels Bio...mentioning

confidence: 99%

“…On the contrary, good adhesion in tissues like liver has also been documented, in which they may play a good replacement role in detriment to more expensive and less available tissue and organ transplants [ 145 ]. In drug delivery, xylan- and galactomannan-based microcapsules have been shown to be excellent colon-specific carriers [ 140 , 146 , 147 ], while xyloglucan mucoadhesive and surface tailoring properties have led to the development of many specific studies [ 141 ]. Galactomannans have also been shown to be useful for drug delivery by the formation of an aerogel structure [ 148 ].…”

Section: Lignocellulosic Materials For the Production Of Biofuels Bio...mentioning

confidence: 99%

Lignocellulosic Materials for the Production of Biofuels, Biochemicals and Biomaterials and Applications of Lignocellulose-Based Polyurethanes: A Review

2022

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The present review is devoted to the description of the state-of-the-art techniques and procedures concerning treatments and modifications of lignocellulosic materials in order to use them as precursors for biomaterials, biochemicals and biofuels, with particular focus on lignin and lignin-based products. Four different main pretreatment types are outlined, i.e., thermal, mechanical, chemical and biological, with special emphasis on the biological action of fungi and bacteria. Therefore, by selecting a determined type of fungi or bacteria, some of the fractions may remain unaltered, while others may be decomposed. In this sense, the possibilities to obtain different final products are massive, depending on the type of microorganism and the biomass selected. Biofuels, biochemicals and biomaterials derived from lignocellulose are extensively described, covering those obtained from the lignocellulose as a whole, but also from the main biopolymers that comprise its structure, i.e., cellulose, hemicellulose and lignin. In addition, special attention has been paid to the formulation of bio-polyurethanes from lignocellulosic materials, focusing more specifically on their applications in the lubricant, adhesive and cushioning material fields. High-performance alternatives to petroleum-derived products have been reported, such as adhesives that substantially exceed the adhesion performance of those commercially available in different surfaces, lubricating greases with tribological behaviour superior to those in lithium and calcium soap and elastomers with excellent static and dynamic performance.

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Xyloglucan for drug delivery applications

Cited by 10 publications

References 103 publications

Antioxidant Properties of Casein Phosphopeptides (CPP) and Maillard-Type Conjugated Products

Antioxidant Properties of Casein Phosphopeptides (CPP) and Maillard-Type Conjugated Products

New Challenges and Prospective Applications of Three-Dimensional Bioactive Polymeric Hydrogels in Oral and Craniofacial Tissue Engineering: A Narrative Review

Lignocellulosic Materials for the Production of Biofuels, Biochemicals and Biomaterials and Applications of Lignocellulose-Based Polyurethanes: A Review

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