Y chromosomal clue successfully facilitated the arrest of Baiyin serial killer

Yao, Hongbing; Wen, Shaoqing; Tong, Xin-Zhu; Zhou, Boyan; Du, Pengfei; Shi, Minjia; Li, Jin; Li, Hui

doi:10.1007/s11434-016-1183-y

Cited by 12 publications

(7 citation statements)

References 10 publications

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“…However, some countries, for example, China (Ge et al, 2013(Ge et al, , 2014 started to accumulate also Y-STR haplotypes in their national DNA databases. In severe crime cases Y chromosome analysis can be seen as a "last resort" technique to collect intelligence information on an unknown perpetrator and to narrow down the number of suspects (Qian et al, 2017;Yao et al, 2016). In Europe a Y-STR profile was used in the elimination process of a mass screening already in 2000 (Dettlaff-Kakol & Pawlowski, 2002) when a serial rapist and murderer called the "Vampire from Świnouj scie" was hunted down in Northern Poland.…”

Section: Investigative Leads Provided By Y-chromosome Testingmentioning

confidence: 99%

Y‐chromosome short tandem repeats in forensics—Sexing, profiling, and matching male DNA

Roewer

2019

WIREs Forensic Science

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The analysis of short tandem repeat (STR) markers located on the Y chromosome is an established method in forensic casework analysis. Usually this method is applied in cases of male‐on‐female sexual assault, in which the victim's DNA is in great excess and masked the male contribution. Y‐STR analysis is able to detect the presence of minuscule amounts of male DNA of one or multiple donors and resulting genetic profiles can be compared to known reference samples. The expert has to determine whether the Y‐STR result of a trace is suitable for a biostatistical calculation in case of a match. The Discrete Laplace method which is implemented in the Y chromosome haplotype reference database (YHRD) can be used to estimate haplotype frequencies with a better approximation than other methods namely the counting method. Moreover, Y‐SNPs in combination with Y‐STRs can infer the biogeographical origin of an unknown male person with comparably high precision due to the availability of a robust phylogenetic tree and large reference data collections. Y‐based ancestry prediction and familial searching can, therefore, provide important investigative leads in crime cases without suspect. This article is categorized under: Forensic Biology > Haploid Markers Forensic Biology > Ancestry Determination using DNA Methods Forensic Biology > DNA Databases and Biometrics Forensic Biology > Forensic DNA Technologies

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Section: Investigative Leads Provided By Y-chromosome Testingmentioning

confidence: 99%

Y‐chromosome short tandem repeats in forensics—Sexing, profiling, and matching male DNA

Roewer

2019

WIREs Forensic Science

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“…Inherited DNA polymorphisms located in the non-recombining portion of the human Y chromosome (NRY) provide a powerful tool for tracking the patrilineal ancestry of male individuals (Poznik et al, 2016;Jobling and Tyler-Smith, 2017;Kayser, 2017;Khan et al, 2017). Various kinds of markers on the Y chromosome, especially the Y-chromosomal short tandem repeats (Y-STRs), have been widely utilized in forensic genetics, particularly in cases where standard autosomal DNA profiling is not informative (Yao et al, 2016;Kayser, 2017;Khan et al, 2017). The Y chromosome is passed from the father to the son unchangeably without considering the gradual accumulation of mutations (Jobling et al, 1997;Jobling and Tyler-Smith, 2017); thus, male individuals in the same paternal lineage share identical Y-STR haplotypes.…”

Section: Introductionmentioning

confidence: 99%

The Validation of a Single Multiplex Typing System With 45 Y-STR Markers for Familial Searching and Database Construction

et al. 2022

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The Y-chromosomal short tandem repeat (Y-STR) is an effective forensic tool in familial searches and patrilineal relationship evaluation. However, currently available Y-STR panels often lack sufficient discriminatory power to resolve genetic relationships between distant relatives or within patrilocal populations. This study aims to establish a novel Y-STR amplification system for forensic casework analysis and database construction, which contains 44 slowly and moderately mutating and one rapidly mutating Y-STR. The validation of the assay was conducted following the recommendations of SWGDAM developmental validation guidelines. Different types of casework samples were tested and reliable profiles were obtained. Furthermore, we genotyped and analyzed 141 unrelated Han Chinese male samples. The results showed that this Y45 kit could improve the performance of identifying male individuals, higher haplotype diversity, and discrimination capacity when compared to the previous widely used Yfiler Plus kit. In general, the validation study demonstrated that the newly developed Y45 kit possesses high sensitivity, inhibitor tolerance, male specificity in a mixture, species specificity, and precision and is capable of forensic casework analysis and database construction.

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“…Since 2014, China has started to promote the establishment of Y-STR database for the purpose of solving cold cases [12], and now most of the Y-STR profiles in the database are based on 16-25 Y-STR markers. Whereupon, a large battery of severe crime cases were solved successfully with the assistance of Y-STR analysis [10,[12][13][14]. Nevertheless, as the number of typing profiles in Y-STR database increased, the difficulties of accurately matching unknown male perpetrators or their paternal lineages increased significantly due to the lower discrimination capacity (DC) of the existed Y-STR genotyping systems.…”

Section: Introductionmentioning

confidence: 99%

Development and validation of a new multiplex Y‐STR panel designed to increase the power of discrimination

Zhou

Cui

et al. 2022

Electrophoresis

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In an attempt to increase the discrimination capacity (DC) and reduce the adventitious match probability, a 6‐dye multiplex Y‐chromosomal short tandem repeat (Y‐STR) panel named Y34plex was constructed that combined 25 Y‐chromosomal markers (DYS456, DYS627, DYS390, DYS570, DYS635, DYS385a/b, DYS448, DYS437, DYS533, DYS449, DYS481, DYS392, DYS391, DYS389I, DYS460, YGATAH4, DYS438, DYS389II, DYS19, DYS458, DYF387S1a/b, DYS439, DYS393, DYS576, and DYS518) in widely used commercial kits, with nine highly polymorphic Y‐STR loci (DYS557, DYS527a/b, DYS593, DYS444, DYS596, DYS643, DYS447, DYS549, and DYS645). The Y34plex is a promising type system to distinguish both unrelated and related male individuals due to the incorporation of rapidly mutated Y‐STR loci. A validation study of the Y34plex was performed and followed the guidelines of the Scientific Working Group on DNA analysis methods. Results show that full Y‐STR profiles were obtained from male/female DNA mixtures with 125 pg of male DNA in the presence of 50 ng of female DNA. The ability to tolerate polymerase chain reaction inhibitors commonly contained in forensic casework samples demonstrated the applicability and robustness of the Y34plex. Compared with the Yfiler Plus kit, the novel panel showed an increased power of discrimination in Chinese Wuxi Han population (n = 434). The overall haplotype diversity of the Y34plex was 0.999606, whereas DC value was 0.956221, which is suitable for use on forensic paternal investigation.

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Y chromosomal clue successfully facilitated the arrest of Baiyin serial killer

Cited by 12 publications

References 10 publications

Y‐chromosome short tandem repeats in forensics—Sexing, profiling, and matching male DNA

Y‐chromosome short tandem repeats in forensics—Sexing, profiling, and matching male DNA

The Validation of a Single Multiplex Typing System With 45 Y-STR Markers for Familial Searching and Database Construction

Development and validation of a new multiplex Y‐STR panel designed to increase the power of discrimination

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