Y-chromosomal diversity in the population of Guinea-Bissau: a multiethnic perspective

Rosa, Alexandra; Ornelas, Carolina; Jobling, Mark A.; Brehm, António; Villems, Richard

doi:10.1186/1471-2148-7-124

Cited by 47 publications

(52 citation statements)

References 53 publications

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“…Haplogroup E-DYS271, which accounts for 470% of the Y chromosomes in most of the populations south of the Sahara, is found on an average at a frequency of 2-3% in Northern Africa, whereas haplogroups J-M304, E-M81, and E-M78, which on the whole account for 50-90% of the northern African male-specific region of the Y chromosome (MSY) gene pool, have been only rarely observed in west/central sub-Saharan Africa. [12][13][14][15][16][17][18][19][20][21][22][23][24][25] A group of chromosomes of potential interest to past trans-Saharan connections is the paragroup R1b1* (R-P25*). Cruciani et al 18 found this paragroup (at that time defined as haplogroup 117, or R-M173*(xSRY 10831 , M18, M73, M269)) to be present at high frequencies (up to 95%) in populations from northern Cameroon.…”

Section: Introductionmentioning

confidence: 99%

Human Y chromosome haplogroup R-V88: a paternal genetic record of early mid Holocene trans-Saharan connections and the spread of Chadic languages

et al. 2010

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Although human Y chromosomes belonging to haplogroup R1b are quite rare in Africa, being found mainly in Asia and Europe, a group of chromosomes within the paragroup R-P25* are found concentrated in the central-western part of the African continent, where they can be detected at frequencies as high as 95%. Phylogenetic evidence and coalescence time estimates suggest that R-P25* chromosomes (or their phylogenetic ancestor) may have been carried to Africa by an Asia-to-Africa back migration in prehistoric times. Here, we describe six new mutations that define the relationships among the African R-P25* Y chromosomes and between these African chromosomes and earlier reported R-P25 Eurasian sub-lineages. The incorporation of these new mutations into a phylogeny of the R1b haplogroup led to the identification of a new clade (R1b1a or R-V88) encompassing all the African R-P25* and about half of the few European/west Asian R-P25* chromosomes. A worldwide phylogeographic analysis of the R1b haplogroup provided strong support to the Asia-to-Africa back-migration hypothesis. The analysis of the distribution of the R-V88 haplogroup in 41800 males from 69 African populations revealed a striking genetic contiguity between the Chadic-speaking peoples from the central Sahel and several other Afroasiatic-speaking groups from North Africa. The R-V88 coalescence time was estimated at 9200-5600 kya, in the early mid Holocene. We suggest that R-V88 is a paternal genetic record of the proposed mid-Holocene migration of proto-Chadic Afroasiatic speakers through the Central Sahara into the Lake Chad Basin, and geomorphological evidence is consistent with this view.

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Section: Introductionmentioning

confidence: 99%

Human Y chromosome haplogroup R-V88: a paternal genetic record of early mid Holocene trans-Saharan connections and the spread of Chadic languages

et al. 2010

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“…By examining the differences between modern Y chromosomes (such as DNA polymorphisms), one can attempt to reconstruct a history of paternal lineages. There have been many studies in this sense in the context of populations of humans (e.g., Hurles et al (1998), , Hurles et al (2002), or Rosa et al (2007)) and other species (e.g., Tosi et al (2002), Hellborg et al (2005), or Geraldes et al (2005)). …”

Section: Introductionmentioning

confidence: 99%

Bisexual branching processes to model extinction conditions for Y-linked genes

González

Martínez

Mota

2009

Journal of Theoretical Biology

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In a two-sex monogamic population, the evolution of the number of carriers of the two alleles of a Y-linked gene is considered. To this end, a multitype bisexual branching model is presented in which it is assumed that the gene has no influence on the mating process. It is deduced from this model that the average numbers of female and male descendants per mating unit constitute the key to determining the extinction or survival of each allele. Moreover, the destiny of each allele in the population is found not to depend on the behaviour of the other.

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“…We further generated additional information to assist in the interpretation of results from STRUCTURE and to correctly infer the underlying genetic structure. Principal component factor analysis (PCA) was performed with the MultiVariate Statistical Package (MVSP) Version 3.13 m software (Kovach and Services, 2004), which was conducted in a zoological and genetic study (Rosa et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

Evidence of balancing selection in multiple indigenous chicken populations

Arlud

Zeng

2016

Genet. Mol. Res.

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ABSTRACT. Microsatellite DNA markers, which are assumed to drift, have been widely used to assess genetic diversity in all major domestic animal species. These markers provide insight into the arrival and dispersion history of a species, with regard to their content or management history. However, no direct evidence supports current standard microsatellite markers falling under this assumption. Therefore, the objective of this study was to investigate the effect and divergence of microsatellites under different types of selection on genetic patterns and population diversity. A total of 192 birds (Gallus gallus) from eight different geographic locations were investigated using 20 microsatellites that are classified into different groups by their selective effect (neutral, positive selection, and balancing selection) by the FDIST2 outlier test. The results showed that most polymorphisms were in the balancing selection marker group, the expected heterozygosity was 0.70, the observed heterozygosity was 0.65, and the mean number of alleles was 6.91. AMOVA revealed that the balancing group contributed the lowest amount of variance among groups, which was -0.60%, the highest variance contributed within the population being 92.28% in comparison with that of other groups. A similar pattern of population genetics was revealed following Slatkin linearized F ST , principal component factor analysis, and population structure by Bayesian clustering. In conclusion, balancing selective markers offer high polymorphism for estimating genetic diversity but reduced genetic divergence between populations.

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Y-chromosomal diversity in the population of Guinea-Bissau: a multiethnic perspective

Cited by 47 publications

References 53 publications

Human Y chromosome haplogroup R-V88: a paternal genetic record of early mid Holocene trans-Saharan connections and the spread of Chadic languages

Human Y chromosome haplogroup R-V88: a paternal genetic record of early mid Holocene trans-Saharan connections and the spread of Chadic languages

Bisexual branching processes to model extinction conditions for Y-linked genes

Evidence of balancing selection in multiple indigenous chicken populations

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