Y chromosome analysis reveals a sharp genetic boundary in the Carpathian region

Stefan, Mihaela; Stefanescu, Gheorge; Gavrilă, Lucian; Terrenato, L.; Jobling, Mark A.; Malaspina, Patrizia; Novelletto, Andrea

doi:10.1038/sj.ejhg.5200580

Cited by 24 publications

(15 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…53 Our data showing high frequency of R1a1a north of the Carpathians and its lower frequency to the South, in the Tisza river valley, are consistent with the genetic boundary previously reported for this region. 16 Copper and Bronze age parallels Figure 2 also shows a remarkable geographic concordance of the R1a1a7-M458 distribution with the Chalcolithic and Early Bronze Age Corded Ware (CW) cultures of Europe that prospered from ca. 5.5À4.5 KYA BP.…”

Section: Phylogeographymentioning

confidence: 81%

Separating the post-Glacial coancestry of European and Asian Y chromosomes within haplogroup R1a

Myres²,

et al. 2009

View full text Add to dashboard Cite

Human Y-chromosome haplogroup structure is largely circumscribed by continental boundaries. One notable exception to this general pattern is the young haplogroup R1a that exhibits post-Glacial coalescent times and relates the paternal ancestry of more than 10% of men in a wide geographic area extending from South Asia to Central East Europe and South Siberia. Its origin and dispersal patterns are poorly understood as no marker has yet been described that would distinguish European R1a chromosomes from Asian. Here we present frequency and haplotype diversity estimates for more than 2000 R1a chromosomes assessed for several newly discovered SNP markers that introduce the onset of informative R1a subdivisions by geography. Marker M434 has a low frequency and a late origin in West Asia bearing witness to recent gene flow over the Arabian Sea. Conversely, marker M458 has a significant frequency in Europe, exceeding 30% in its core area in Eastern Europe and comprising up to 70% of all M17 chromosomes present there. The diversity and frequency profiles of M458 suggest its origin during the early Holocene and a subsequent expansion likely related to a number of prehistoric cultural developments in the region. Its primary frequency and diversity distribution correlates well with some of the major Central and East European river basins where settled farming was established before its spread further eastward. Importantly, the virtual absence of M458 chromosomes outside Europe speaks against substantial patrilineal gene flow from East Europe to Asia, including to India, at least since the mid-Holocene.

show abstract

Section: Phylogeographymentioning

confidence: 81%

Separating the post-Glacial coancestry of European and Asian Y chromosomes within haplogroup R1a

Myres²,

et al. 2009

View full text Add to dashboard Cite

show abstract

“…Previous continental-range studies detected broad and smooth haplogroup frequency clines (Malaspina et al 1998;Rosser et al 2000;Semino et al 2000;Underhill et al 2000;Karafet et al 2001;Wells et al 2001). However, studies focused on discrete regions (Stefan et al 2001;Weale et al 2001;Qamar et al 2002;Zerjal et al 2002;Di Giacomo et al 2003;Cinnioglu et al 2004;Flores et al 2004;Nasidze et al 2004Nasidze et al , 2005 and on specific haplogroups (Cruciani et al 2004;Di Giacomo et al 2004;Rootsi et al 2004;Semino et al 2004) have found geographic barriers, strong microdifferentiation, and additional minor clines, stressing the importance of local isolation and secondary diffusions in the making of the modern Y-chromosome landscape.…”

Section: Introductionmentioning

confidence: 99%

Isolates in a corridor of migrations: a high-resolution analysis of Y-chromosome variation in Jordan

et al. 2005

View full text Add to dashboard Cite

A high-resolution, Y-chromosome analysis using 46 binary markers has been carried out in two Jordan populations, one from the metropolitan area of Amman and the other from the Dead Sea, an area geographically isolated. Comparisons with neighboring populations showed that whereas the sample from Amman did not significantly differ from their Levantine neighbors, the Dead Sea sample clearly behaved as a genetic outlier in the region. Its high R1*-M173 frequency (40%) has until now only been found in northern Cameroonian samples. This contrasts with the comparatively low presence of J representatives (9%), which is the modal clade in Middle Eastern populations, including Amman. The Dead Sea sample also showed a high presence of E3b3a-M34 lineages (31%), which is only comparable to that found in Ethiopians. Although ancient and recent ties with sub-Saharan and eastern Africans cannot be discarded, it seems that isolation, strong drift, and/or founder effects are responsible for the anomalous Y-chromosome pool of this population. These results demonstrate that, at a fine scale, the smooth, continental clines detected for several Y-chromosome markers are often disrupted by genetically divergent populations.

show abstract

“…Here we report on the results of the characterization of MSY diversity in a population of central Europe as obtained with a sampling scheme that detected population substructure in other European countries Stefan et al, 2001;Brion et al, 2004;Roewer et al, 2005). Indeed, the area here investigated is crucial to understanding the origin of the present-day genetic landscape of the Continent, as it lies on routes that had inevitably to be involved in a wide range of processes, including repopulation events from glacial refugia, population inputs from the Asian-European border, as well as local expansions triggered by major technological advances.…”

mentioning

confidence: 99%

Y‐chromosomal variation in the Czech Republic

Luca

Giacomo

Benincasa

et al. 2006

American J Phys Anthropol

View full text Add to dashboard Cite

To analyze the contribution of the Czech population to the Y-chromosome diversity landscape of Europe and to reconstruct past demographic events, we typed 257 males from five locations for 21 UEPs. Moreover, 141 carriers of the three most common haplogroups were typed for 10 microsatellites and coalescent analyses applied. Sixteen Hg's characterized by derived alleles were identified, the most common being R1a-SRY(10831) and P-DYS257*(xR1a). The pool of haplogroups within I-M170 represented the third most common clade. Overall, the degree of population structure was low. The ages for Hg I-M170, P-DYS257*(xR1a), and R1a-SRY(10831) ap peared to be comparable and compatible with their presence during or soon after the LGM. A signal of population growth beginning in the first millennium B.C. was detected. Its similarity among the three most common Hg's indicated that growth was characteristic for a gene pool that already contained all of them. The Czech population appears to be influenced, to a very moderate extent, by genetic inputs from outside Europe in the post-Neolithic and historical times. Population growth postdated the archaeologically documented introduction of Neolithic technology and the estimated central value coincides with a period of repeated changes driven by the development of metal technologies and the associated social and trade organization.

show abstract

Y chromosome analysis reveals a sharp genetic boundary in the Carpathian region

Cited by 24 publications

References 20 publications

Separating the post-Glacial coancestry of European and Asian Y chromosomes within haplogroup R1a

Separating the post-Glacial coancestry of European and Asian Y chromosomes within haplogroup R1a

Isolates in a corridor of migrations: a high-resolution analysis of Y-chromosome variation in Jordan

Y‐chromosomal variation in the Czech Republic

Contact Info

Product

Resources

About