Y-STR markers from Ladakh in the Himalayas

Perez-Benedico, David; Chennakrishnaiah, Shilpa; Gayden, Tenzin; Rowold, Diane J.; Garcia-Bertrand, Ralph; Herrera, René J.

doi:10.1016/j.legalmed.2016.04.007

Cited by 8 publications

(3 citation statements)

References 26 publications

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“…This hypothesis is supported by the abundant occurrence of haplogroups M9, A21, and I4b (Kumar, et al 2024). Several factors have led to the rich mix of ethnic diversity in the region, including the emergence of regimes and kingdoms such as the Kushan Empire, frequent Mughal invasions in the 14th to 16th centuries, and the slave trade in Central Asia in the 18th century (Jina 1996; Rizvi 2001; Perez-Benedico, et al 2016; Rowold, et al 2016). Analysis of the haplogroup base of Himalayan and adjacent populations shows high levels of genetic heterozygosity and massive interpopulation exchange, as well as a strong presence of shared ancestry between these groups (Tamang, et al 2018b).…”

Section: Discussionmentioning

confidence: 99%

“…The abundance and diversity of mitochondrial haplogroup M9 highlight the potential genetic contribution of the Tibetan Plateau and China 30 . This genetic proximity to East Asians is also supported by the frequency of Hg A, a haplogroup not so common in India but very common among Tibeto-Burmans, including Tibetans and Mongolians [28][29][30][31][32] . Genetic studies carried out to date are based on a limited number of samples and low-resolution markers.…”

Section: Introductionmentioning

confidence: 95%

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Genetic architecture and adaptation of Ladakh highlanders of trans-Himalayas

Kumar,

Rajpal,

Ahlawat

et al. 2024

Preprint

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The Ladakh in the trans-Himalayas has witnessed complex cultural movements, genetic assimilation and demographic changes since the Neolithic period, which continue despite the harsh, inhospitable and cold climate. Although geographically isolated from mainland South Asia, Ladakh has historic trade routes (the Silk Road) and is well connected and accessible to travelers from Tibet and Central Asia. Despite its rich cultural heritage, a detailed description of the genetic landscape of the Ladakh region is completely lacking, particularly with regard to genome-wide markers and larger sample sizes. Therefore, in our current study, we genotyped 80 individuals from Kargil and Leh districts of the Union Territory of Ladakh, India. Here, we performed a comprehensive genetic analysis based on allele frequency and haplotype sharing. Our analysis revealed the presence of two distinct genetic lineages in the region with quite different genetic composition. The population of the Leh region is more similar to East Asian and Southeast Asian populations with population drift. In contrast, the population of the Kargil region is more similar to the Indo-European population. The former group shares a genetic history with Tibetans and Sherpas, while the latter group from Kargil associates with Kashmiri Muslims, Gujjars and Nepalese Brahmins. For both groups, there was a founder event at about 18th to 22th generations ago and duration coincided with the Mughal invasion. The genome-wide scan for a signal of positive selection revealed genetic signatures of altitude adaptation in the Leh population, while in the Kargil population the key gene signatures were associated with immunity and female fertility.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 95%

Genetic architecture and adaptation of Ladakh highlanders of trans-Himalayas

Kumar,

Rajpal,

Ahlawat

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…The pairwise genetic distance (R st ) between the present population and reference populations from the YHRD are given in Supplementary Table 5 [1] , [2] , [3] , [4] , [5] , [6] , [7] . The YHRD accession numbers of reference populations are listed in Supplementary Table 6 .…”

Section: Data Descriptionmentioning

confidence: 99%