Y-type DNA structure stabilized p-type CuS quantum dots to quench photocurrent of ternary heterostructure for sensitive photoelectrochemical detection of miRNA

Wen, Yu; Qing, Min; Chen, Sheng Liang; Luo, Hong Qun; Li, Nian Bing

doi:10.1016/j.snb.2020.129257

Cited by 14 publications

(5 citation statements)

References 32 publications

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“…Figure 2D matches Mo 3d3/2 at 231.6 eV and Mo 3d5/2 at 228.4 eV with Mo 4+ [34]. The XPS spectra of Cu 2p is shown in Figure 2E, with peaks centered at 932.4 eV (Cu 2p3/2) and 952.4 eV (Cu 2p1/2), indicating that Cu is present in the Cu 2+ state [35,36]. According to Figure 2F, the doublet peak at 167.9 eV was a candidate for S 2p1/2, while the peak at 162.5 eV was for S 2p3/2, indicating the presence of metal sulfides [37,38].…”

Section: Physical Characterizationmentioning

confidence: 58%

“…Calculations yielded a Bi 2 WO 6 band gap of 1.86 eV. Notably, the band gaps were significantly lower compared with the literature (2.56 eV for Bi 2 WO 6 ) [35], which was likely due to the defected GGA function (Figure 5A,B). In the photocatalyst, photogenerated h+ and e-were efficiently isolated and quickly transported onto surfaces.…”

Section: Theoretical Calculationsmentioning

confidence: 70%

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A Visible-Light-Active CuS/MoS2/Bi2WO6 Aptamer Sensitively Detects the Non-Steroidal Anti-Inflammatory Drug Diclofenac

Gao

Liu

2022

Nanomaterials

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Diclofenac is a non-steroidal, anti-inflammatory drug and is clinically used for the treatment of osteoarthritis, non-articular rheumatism, etc. This research aimed to demonstrate the creation of an upgraded photoelectrochemical (PEC) aptamer sensor for detecting diclofenac (DCF) with high sensitivity. In this work, photoactive materials and bio-identification components served as visible-light-active CuS/MoS2/Bi2WO6 heterostructures and aptamers, respectively. CuS and MoS2/Bi2WO6 were combined to improve photocurrent responsiveness, which helped the structure of PEC aptasensors. Additionally, the one-pot synthesis of CuS/MoS2/Bi2WO6 was ecologically beneficial. With these optimizations, the photocurrent response of aptamer/CS/CuS/MoS2/Bi2WO6 exhibited linearity between 0.1 and 500 nM DCF. The detection limit was 0.03 nM (S/N = 3). These results suggest that the PEC sensing technique might produce an ultra-sensitive sensor with high selectivity and stability for DCF detection.

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Section: Physical Characterizationmentioning

confidence: 58%

Section: Theoretical Calculationsmentioning

confidence: 70%

A Visible-Light-Active CuS/MoS2/Bi2WO6 Aptamer Sensitively Detects the Non-Steroidal Anti-Inflammatory Drug Diclofenac

Gao

Liu

2022

Nanomaterials

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“…The detection of miRNA-21 was proposed by Wen et al 127 in 2021, through a photoelectrochemical biosensor. The authors constructed a biosensor composed of a ternary heterostructure (SnO 2 /CdCO 3 /CdS nanomaterial) immobilized into an electrode, and a Y-type DNA structure stabilized by p-type CuS quantum dots, capped by TGA.…”

Section: Sensing Of Cancer Mirnas Biomarkersmentioning

confidence: 99%

Quantum Dots for Cancer-Related miRNA Monitoring

2022

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Quantum dots (QDs) possess exceptional optoelectronic properties that enable their use in the most diverse applications, namely, in the medical field. The prevalence of cancer has increased and has been considered the major cause of death worldwide. Thus, there has been a great demand for new methodologies for diagnosing and monitoring cancer in cells to provide an earlier prognosis of the disease and contribute to the effectiveness of treatment. Several molecules in the human body can be considered relevant as cancer markers. Studies published over recent years have revealed that micro ribonucleic acids (miRNAs) play a crucial role in this pathology, since they are responsible for some physiological processes of the cell cycle and, most important, they are overexpressed in cancer cells. Thus, the analytical sensing of miRNA has gained importance to provide monitoring during cancer treatment, allowing the evaluation of the disease’s evolution. Recent methodologies based on nanochemistry use fluorescent quantum dots for sensing of the miRNA. Combining the unique characteristics of QDs, namely, their fluorescence capacity, and the fact that miRNA presents an aberrant expression in cancer cells, the researchers created diverse strategies for miRNA monitoring. This review aims to present an overview of the recent use of QDs as biosensors in miRNA detection, also highlighting some tutorial descriptions of the synthesis methods of QDs, possible surface modification, and functionalization approaches.

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“…Carbon quantum dots (CQDs) are a good biorecognition linker because their surfaces have rich functional groups. − Many types of CQDs have been designed in many applications of biosensors to enhance their performances. ,, However, the CQDs of fluorescence technology for DNA detection suffer from a low detection limit of nanomolar level (17.4 nM) . Recently, our group presented a new CQD-functionalized SGGT for Fe 3+ ion detection and Cu 2+ ion detection.…”

Section: Introductionmentioning

confidence: 99%

Ultrasensitive Label-Free DNA Detection Based on Solution-Gated Graphene Transistors Functionalized with Carbon Quantum Dots

Deng

Xiao

et al. 2022

Anal. Chem.

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Developing highly sensitive, reliable, cost-effective label-free DNA biosensors is challenging with traditional fluorescence, electrochemical, and other techniques. Most conventional methods require labeling fluorescence, enzymes, or other complex modification. Herein, we fabricate carbon quantum dot (CQD)-functionalized solution-gated graphene transistors for highly sensitive label-free DNA detection. The CQDs are immobilized on the surface of the gate electrode through mercaptoacetic acid with the thiol group. A single-stranded DNA (ssDNA) probe is immobilized on CQDs by strong π–π interactions. The ssDNA probe can hybridize with the ssDNA target and form double-stranded DNA, which led to a shift of Dirac voltage and the channel current response. The limit of detection can reach 1 aM which is 2–5 orders of magnitude lower than those of other methods reported previously. The sensor also exhibits a good linear range from 1 aM to 0.1 nM and has good specificity. It can effectively distinguish one-base mismatched target DNA. The response time is about 326 s for the 1 aM target DNA molecules. This work provides good perspectives on the applications in biosensors.

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Y-type DNA structure stabilized p-type CuS quantum dots to quench photocurrent of ternary heterostructure for sensitive photoelectrochemical detection of miRNA

Cited by 14 publications

References 32 publications

A Visible-Light-Active CuS/MoS2/Bi2WO6 Aptamer Sensitively Detects the Non-Steroidal Anti-Inflammatory Drug Diclofenac

A Visible-Light-Active CuS/MoS2/Bi2WO6 Aptamer Sensitively Detects the Non-Steroidal Anti-Inflammatory Drug Diclofenac

Quantum Dots for Cancer-Related miRNA Monitoring

Ultrasensitive Label-Free DNA Detection Based on Solution-Gated Graphene Transistors Functionalized with Carbon Quantum Dots

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