2005
DOI: 10.1186/cc3782
|View full text |Cite
|
Sign up to set email alerts
|

Untitled

Abstract: Preclinical studies in animals and ex vivo human blood have provided a solid rationale for conducting prospective randomized trials in trauma patients. Small animal models have been utilized to study the efficacy of recombinant activated factor VII (rFVIIa; NovoSeven®) in treating thrombocytopenic rabbits and for the reversal of anticoagulation. Safety models in the rabbit also exist to test for systemic activation of clotting and pathologic thrombosis. Animal models simulating traumatic injuries in humans hav… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
2

Citation Types

3
8
0

Year Published

2007
2007
2019
2019

Publication Types

Select...
6
1
1

Relationship

0
8

Authors

Journals

citations
Cited by 21 publications
(11 citation statements)
references
References 21 publications
3
8
0
Order By: Relevance
“…Hypertensive disorders followed by obstetric haemorrhage were the common causes for ICU transfer in the present study similar to other national 5–7 and international studies 12,16 . There was an increase in the incidence of sepsis due to obstetric or non-obstetric causes in the recent studies − 11.4% 6 , 27.15% 7 , 13.17% 8 , 12.5% 10 .…”
Section: Discussionsupporting
confidence: 90%
See 1 more Smart Citation
“…Hypertensive disorders followed by obstetric haemorrhage were the common causes for ICU transfer in the present study similar to other national 5–7 and international studies 12,16 . There was an increase in the incidence of sepsis due to obstetric or non-obstetric causes in the recent studies − 11.4% 6 , 27.15% 7 , 13.17% 8 , 12.5% 10 .…”
Section: Discussionsupporting
confidence: 90%
“…The maternal mortality rate varied widely between developed and developing countries. It ranged between low or no maternal deaths 9,10,12,14,16 in the former to as high as 41.67% 13 in the later. The present study population had a mortality rate of 9.9%.…”
Section: Discussionmentioning
confidence: 96%
“…Studies by Sriram and Robertson[11] and Crozier and Wallace[15] did not report even a single maternal death, and the mortality rate was consistently below 5% in other reports from ICUs of developed countries. [101216] The CCU obstetric mortality rate of 33.66% in our study matches with most of the contemporary Indian studies. [171819202226] A low mortality rate of 6.5% reported by Harde et al[23] from a postanesthesia ICU may not be a representation of maternal mortality in a general CCU and a study by Bhadade et al[18] from the medical ICU of the same institute reports a high maternal mortality rate of 30.3%.…”
Section: Discussionsupporting
confidence: 87%
“…SMR was the most commonly reported form of calibration (n = 26), ranging from 0 to 1.57. Only 4 studies reported the Hosmer-Lemeshow goodness-of-fit test [50,53,54,61]. Four studies investigated classification measures (e.g.…”
Section: Resultsmentioning
confidence: 99%
“…Thirty studies explored 7 predictive models developed primarily from non-obstetric patient populations—the Simplified Acute Physiology Score 2 and 3, Acute Physiology and Chronic Health Evaluation Score 2 and 3, Sequential Organ Failure Assessment, and the Mortality Probability Model, versions 2 and 3) [4,17,40–49,28,5053,5557,59,60,62,3236,38,39] (Fig 4)—that were initially developed from non-obstetric critically ill patient populations and incorporated patient characteristics , comorbidities , physiological and laboratory-based data . The AUC across these 7 models was near 0.80, demonstrating good discriminative ability.…”
Section: Resultsmentioning
confidence: 99%