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Abstract

The process of wound healing begins immediately following surface lesions or just after exposure to radiation, chemical agents or extreme temperatures. Taurine (2-aminoethane sulfonic acid), an amino acid containing sulfur, is found in almost all tissues in mammals, playing various important physio-logical roles in each organ. Taurine exhibits an antioxidant effect and is also known to have effects on cell proliferation, inflammation and collagenogenesis. Many antioxidants have been used to eliminate the negative effects of oxygen free radicals on wound healing. The objective of the present study was to examine the wound healing effect in mice of taurine-chitosan gel, which releases taurine slowly over a long time period. Fifty mM of taurine in 1.5% chitosan polymer (TAU-GEL) and 1.5% chitosan polymer (CHI-GEL) were applied to full thickness skin wounds of mice once a day for seven days. After seven days of treatment, lipid peroxide formation-malondialdehyde (MDA) and hydroxyproline (HPX) levels and the tensile strength of wound tissues were measured. All results were compared with those of the untreated control group (CONT). The structural alterations in the skin layers were also histologically investigated. It was found that locally administered TAU-GEL form significantly increased wound tensile strength by decreasing the MDA and increasing HPX levels. These results were supported by histological findings. All observations suggest that taurine gel may be effective in wound healing.

Chitosan preparations for wounds and burns: antimicrobial and wound-healing effects

“…Chitosan and its derivatives could accelerate wound healing by enhancing the functions of inflammatory cells, such as polymorphonuclear leukocytes (PMN) [4,29–31], macrophages [4,32,33], and fibroblasts [4,34–36] or osteolasts [37]. It has also been reported that chitosan could increase the tensile strength of wounds [38]. The wound-healing effects of chitosan could be affected by the factors of molecular weight [33,39,40], deacetylation degree [35,39,40], as well as the state of chitosan [41].…”

Curcumin-loaded Chitosan Tripolyphosphate Nanoparticles as a safe,natural and effective antibiotic inhibits the infection of Staphylococcusaureus and Pseudomonas aeruginosa in vivo

“…Chitosan could accelerate coagulation and enhance the functions of inflammatory cells (13)(14)(15)(16). Moreover, it has been reported that chitosan could increase the tensile strength of wounds (17).…”

Biochemical and biomechanical assessment of effects of l-carnitine on oral mucosal wounds

“…In literature, many research studies have investigated the effect of topical insulin administration [18], epidermal growth factor [19], fibroblast growth factor, vitamin E [20,21], selenium [22], and taurine [16] on the healing process of tissue defects that have been created in oral mucosa and on oxidative stress. There are also other research studies that have examined the effects of Lcarnitine on the healing of defects developed on the skin [1,[23][24][25][26].…”

“…For this purpose, the method developed by Woessner [15] has been used by implementing various modifications to the method [16]. Standard hydroxyproline was run and values reported as microgram per milligram dry weight of tissue [17].…”