2023
DOI: 10.3390/nu15143281
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Yacon (Smallanthus sonchifolius) Flour Reduces Inflammation and Had No Effects on Oxidative Stress and Endotoxemia in Wistar Rats with Induced Colorectal Carcinogenesis

Abstract: Colorectal cancer has a high worldwide incidence. The aim of this study was to determine the effect of yacon flour (YF) on oxidative stress, inflammation, and endotoxemia in rats with induced colorectal cancer (CRC). The Wistar male rats were divided and kept for 8 weeks in four groups: S (basal diet, n = 10), Y (YF flour + basal diet, n = 10), C (CRC-induced control + basal diet, n = 12), CY (CRC-induced animals + YF, n = 12). CRC was induced by intraperitoneal injections of 1,2-dimethylhydrazine (25 mg/kg bo… Show more

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Cited by 3 publications
(5 citation statements)
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“…In other studies the beneficial effects of yacon on the immunological status of mice 36 have been observed and yacon consumption increased the fecal IgA levels in CRC-induced rats. 61…”
Section: Discussionmentioning
confidence: 99%
“…In other studies the beneficial effects of yacon on the immunological status of mice 36 have been observed and yacon consumption increased the fecal IgA levels in CRC-induced rats. 61…”
Section: Discussionmentioning
confidence: 99%
“…Cancer increased TNF-α levels and SCFA production, while decreasing total antioxidant capacity. However, using yacon flour decreased intraluminal pH, TNF-α, and the TNF-α/IL-10 ratio and augmented secretory immunoglobulin A, suggesting its potential in maintaining intestinal health and mitigating CRC damage in animal models [8].…”
Section: Antioxidant and Anti-inflammatory Effects Of Yacon Flour: In...mentioning
confidence: 99%
“…Caffeic acid Metabolic effects: antidiabetic; other effects: antidepressant, anticancer, and antiviral [35,36] Chlorogenic acid Metabolic effects: anti-inflammatory, antioxidant, and antidiabetic [37,38] Enhydrin Metabolic effects: antidiabetic and antioxidant; other effects: antimicrobial [39,40] Ferulic acid Metabolic effects: antidiabetic; other effects: antimicrobial and anti-carcinogenic [41,42] Melampolide Metabolic effects: antioxidant and reduces angiogenesis; other effects: antimicrobial, inhibition of DNA synthesis, and increased cell apoptosis [43,44] Phenolic acid Metabolic effects: anti-inflammatory, antidiabetic, and antioxidant; other effects: antimicrobial and anticancer [45,46] Uvedafolin Metabolic effects: antidiabetic and anti-inflammatory; other effects: anti-bacterial (against Anthracis and MRSA) and anticancer [47,48] Additionally, some studies suggest that yacon may help protect the liver from damage caused by toxic substances, also due to the antioxidant and anti-inflammatory properties [8,49].…”
Section: Bioactive Compound Biological Effects Referencesmentioning
confidence: 99%
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