YAG-OPO Laser for PDT Application

Udagawa, T.; Inoue, Katsushi; Fukutomi, Seiji; Takaoka, Keigo

doi:10.2530/jslsm1980.16.3_25

Cited by 2 publications

(4 citation statements)

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“…Therefore, a small solid state laser would be useful for PDT. Since the YAG-OPO laser is all solid state laser except for the flash lamps, it is more reliable, smaller and has less consumables than argon-dye laser or excimer-dye laser [4]. Moreover, the tunability of its wavelength enables it to be used with various kinds of photosensitizers; hematoporphyrin derivative (630 nm), 5-ALA (630 nm), pheophorbide-a (650nm), mono-L-aspartyl chlorin e6 (664nm), aluminum phthalocyanine (670 nm), etc [7].…”

Section: Discussionmentioning

confidence: 99%

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Photodynamic Therapy With YAG‐OPO Laser for Early Stage Lung Cancer

Kato

Okunaka

Konaka

et al. 1997

Diagnostic and Therapeutic Endoscopy

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Photodynamic therapy (PDT) utilizing Photofrin is proving to be effective for the treatment of early stage lung cancers. The effect of PDT utilizing YAG-OPO laser as new light source was evaluated in 26 patients (29 lesions) with early stage lung cancers. YAG-OPO laser is solid state tunable laser which is easy to change wavelength between 620 and 670 nm exciting various kinds of photosensitizers. Moreover, YAG-OPO laser is more reliable, smaller and has less consumables than argon-dye laser or excimer-dye laser. As the result of PDT with YAG-OPO laser, complete remission (CR) was obtained in 82.6% of the 29 lesions, partial remission (PR) in 13.8% and no change (NC) was obtained in 3.4%. We conclude that PDT utilizing YAG-OPO laser is efficacious in the treatment of early stage lung cancers and can achieve complete remission.

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Section: Discussionmentioning

confidence: 99%

“…Furthermore, the function of photo-coagulation for YAG laser (Max. Power: 10 W) is available as an option [4].…”

Section: Laser Equipmentmentioning

confidence: 99%

Photodynamic Therapy With YAG‐OPO Laser for Early Stage Lung Cancer

Kato

Okunaka

Konaka

et al. 1997

Diagnostic and Therapeutic Endoscopy

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“…and a pulse laser. The pulse lasers we used were mainly an excimer dye laser [4] (EDL: model EDL PDT-1, Hamamatsu Photonics, Hamamatsu, Japan) and partially between 1995 and 1996 an optical parametric oscillator system pumped by a Q-switched Nd:YAG laser [5] (YOL: model iLS-TL-50A, Ishikawajima-Harima Heavy Industries (IHI),…”

Section: Injectionmentioning

confidence: 99%

“…Kato et al [11] endoscopically delivered more than 200J/cm 2 by an ADL and more than 100 J/cm 2 by an EDL for lung cancer. Udagawa [5] reported the results of clinical trials of PDT in several organs using a YOL, in which he reported 100-300 J/cm 2 for early lung cancer and CIS of the uterine cervix, and 60-180 J/cm 2 for early gastric cancer and superficial esophageal cancer. We gave 204 J/cm 2 for our first case of superficial esophageal cancer and 90 J/cm 2 for our first case ofearly gastric cancer.…”

Section: Energy Intensitymentioning

confidence: 99%

Progress of Photodynamic Therapy in Gastric Cancer

Mimura

Narahara

Otani

et al. 1999

Diagnostic and Therapeutic Endoscopy

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Progress of photodynamic therapy (PDT) in gastric cancer and the clinical outcome are described in this paper. (1) We included the whole lesion and a 5 mm margin in the field for irradiation. Marking by injection of India-ink showing the irradiation field was performed beforehand. (2) We established the standard light dose to be 90 J/cm2 for an argon dye laser and 60 J/cm2 for a pulse wave laser. (3) The size of cancerous lesion curable by PDT was expanded from 3 cm in diameter, i.e. 7 cm2 in area to 4 cm in diameter, i.e. 13 cm2 by employing a new excimer dye laser model, which could emit 4mJ/pulse with 80 Hz pulse frequency. (4) The depth of cancer invasion which could be treated by PDT was increased from about 4 mm, i.e. the superficial part of the submucosal layer (SM-1) to more than 10 mm in depth, i.e. the proper muscular layer. These improvements owe much to the pulse laser, the photodynamic action induced by which permits deeper penetration than that of a continuous wave laser. (5) We employed a side-viewing fiberscope for gastric PDT to irradiate the lesion from an angle of 90°. (6) We designed a simple cut quartz fiber for photoradiation with a spiral spring thickened toward the end. (7) We developed an endoscopic device for photoradiation in PDT which achieves accurate and efficient irradiation. As a result of these improvements a higher cure rate was obtained even with a lower light dose of irradiation.

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YAG-OPO Laser for PDT Application

Cited by 2 publications

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Photodynamic Therapy With YAG‐OPO Laser for Early Stage Lung Cancer

Photodynamic Therapy With YAG‐OPO Laser for Early Stage Lung Cancer

Progress of Photodynamic Therapy in Gastric Cancer

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