2023
DOI: 10.3390/ijms241512491
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YAP at the Crossroads of Biomechanics and Drug Resistance in Human Cancer

Miao Huang,
Heyang Wang,
Cole Mackey
et al.

Abstract: Biomechanical forces are of fundamental importance in biology, diseases, and medicine. Mechanobiology is an emerging interdisciplinary field that studies how biological mechanisms are regulated by biomechanical forces and how physical principles can be leveraged to innovate new therapeutic strategies. This article reviews state-of-the-art mechanobiology knowledge about the yes-associated protein (YAP), a key mechanosensitive protein, and its roles in the development of drug resistance in human cancer. Specific… Show more

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