An efficient self-stimulated Raman laser of Nd:Lu x Y 1−x VO 4 (x = 0.1, 0.26, 0.41, 0.61, 0.67 and 0.8) series crystals was demonstrated for the first time. Compared to YVO 4 , the relative Raman gain coefficients were determined by studying their spontaneous Raman scattering spectra. With the largest thermal conductivity, excellent energy storage capability and moderate Raman gain coefficient, the Nd:Lu 0.26 Y 0.74 VO 4 crystal presented the best Raman laser performance: 2.3 W average output power, 71 µJ single pulse energy and 26.3 kW peak power. The results indicated that the Nd:Lu 0.26 Y 0.64 VO 4 crystal should be an excellent self-Raman laser material.