YCM1008A, a Novel Ca2+-Signaling Inhibitor, Produced by Fusarium sp. YCM1008

Abstract

In the course of screening for drugs that suppress the Ca(2+)-mediated growth inhibition in a yeast mutant, we found that the metabolite of Fusarium sp. strain YCM1008 inhibited Ca(2+)-signaling. A novel pyrano-pyridone, YCM1008A was isolated from the fermentation broth using HLB column chromatography followed by HPLC, and the structure was elucidated by spectral analysis. YCM1008A suppressed Ca(2+)-induced growth inhibition of the Saccharomyces cerevisiae (Deltazds1Deltasyr1) mutant.

Structural Simplification of Bioactive Natural Products with Multicomponent Synthesis. 2. Antiproliferative and Antitubulin Activities of Pyrano[3,2-c]pyridones and Pyrano[3,2-c]quinolones

“…29 It is noteworthy that all potent analogues have a 3-bromo substituent on the aromatic ring at position C4 of the pyranopyridone skeleton (compounds 8-14) and this preference is uniform irrespective of the substitution pattern of this aromatic moiety. The 3-chloro (15) and other variously substituted analogues (16)(17)(18) are significantly less potent or are totally inactive. Further, the substitution of the nitrogen in the pyridone ring by oxygen, as in pyranopyranone 19, abolishes the activity as well.…”

“…This structural motif is broadly represented by pyranopyridone and pyranoquinolone alkaloids manifesting diverse biological activities. The latter include antibacterial, [10][11][12] antifungal and antialgal, 13 antiinflammatory 14 and antimalarial 15 properties as well as inhibition of calcium signaling, 16 platelet aggregation 17 and nitric oxide production. 18 Furthermore, many of these alkaloids exhibit cancer cell growth-inhibitory activity and are investigated as potential anticancer agents.…”

Inhibition of Ca2+-Signal-Dependent Growth Regulation by Radicicol in Budding Yeast

“…8) The active principles of the samples were isolated and their structure was determined. Among several active substances identified, radicicol, an antifungal metabolite of 14-membered macrolide originally isolated from Monosporium bonorden, 9) was identified in three of the active samples.…”

One-pot synthesis of pyrano[3,2-c]quinoline-2,5-dione derivatives by Fe3O4@SiO2-SO3H as an efficient and reusable solid acid catalyst

“…Pyranoquinoline is an example of heterocyclic compounds that studying their attributes due to the important biological properties and various medicinal applications is highly important. In addition to the above-mentioned activities for the quinolones derivatives, various biological activities such as antibacterial, antifungal and anti-platelet aggregation has been also reported on them [15][16][17]. Natural resources for the preparation of these compounds are limited and in most cases, should be handled as a difficult process for their isolation and purification of them [18,19].…”