Year in review 2008: Critical Care - nephrology

Abstract

We summarize original research in the field of critical care nephrology accepted or published during 2008 in Critical Care and, when considered relevant or directly linked to this research, in other journals. Three main topics have been identified for a rapid overview. (1) The classification of acute kidney injury, with particular attention to differences and similarities between the RIFLE and AKIN classifications. (2) Fluid balance in patients requiring renal replacement therapy (RRT) has been shown as an independent risk factor for mortality in critically ill patients: current evidence and uncertainties are described. (3) Management of anticoagulation during RRT has been explored by several researchers in 2008: diagnosis of heparin-induced thrombocytopenia, the use of tirofiban and optimal anticoagulation during drotrecogin A activated treatment have been evaluated.

Hematopoietic stem cell transplantation and acute kidney injury in children: A comprehensive review

“…Mitomycin C has a direct dosing‐to‐risk relationship with TMA. Cumulative doses of mitomycin C over 40‐60 mg/m 2 are statistically associated with TMA development . Gemcitabine‐induced TMA is quite similar in pathogenesis and onset.…”

“…Cumulative doses of mitomycin C over 40-60 mg/m 2 are statistically associated with TMA development. 54 Gemcitabine-induced TMA is quite similar in pathogenesis and onset. However, gemcitabine-related TMA is not associated with dosing, although that risk may increase following 4-6 months or more of use.…”

Year in review 2009: Critical Care - nephrology

“…Last year, in the 'Year in review 2008: Critical Care--nephrology' [ 7 ], we commented on the work by Steinvall and colleagues [ 8 ], who analyzed AKI incidence in a cohort study of patients with burns to more than 20% of total body surface area (TBSA). Of these patients, 24% developed AKI and 3% required dialysis.…”