Year in review 2012: Acute lung injury, interstitial lung diseases, sleep and physiology

Eves, Neil D.; Song, Yuanlin; Piper, Amanda J.; Maher, Toby M.

doi:10.1111/resp.12053

Cited by 8 publications

(9 citation statements)

References 91 publications

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“…The prognosis of most ILD is generally more closely associated with the severity of pulmonary fibrosis than the severity of inflammation because fibrosis is usually irreversible, whereas inflammation tends to be more reversible. 15,16,21 Considering all the clinical findings of our non-survivors, the prognosis of HD-chILD seemed to be more closely related to excessive inflammation than fibrosis. As well, the control of excessive inflammation seemed to be a key factor in determining survival in HD-chILD.…”

Section: Discussionmentioning

confidence: 82%

“…[12][13][14] However, ILD is still a very diverse disease group, with a high mortality and morbidity and an increasing prevalence. 15 There have been continuing efforts to determine reliable prognostic factors and effective treatments through increased understanding of the pathophysiology of ILD. 16,17 Several possible prognostic markers have been proposed, including interleukin 8 (IL-8), matrix metalloproteinase (MMP), vascular endothelial growth factor (VEGF), transforming growth factor beta (TGF-b), Krebs von den Lungen-6 (KL-6; a representative inflammatory and fibrotic cytokine), and monocyte chemotactic protein 1 (MCP-1).…”

Section: Introductionmentioning

confidence: 99%

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Transforming growth factor‐beta 1 in humidifier disinfectant‐associated children's interstitial lung disease

Kim

Lee

et al. 2015

Pediatric Pulmonology

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Non-survivors exhibited more inflammatory clinical findings than survivors. Transforming growth factor-beta 1 remained elevated in survivors, suggesting that it affected the clinical course of humidifier disinfectant-associated children's interstitial lung disease. The prognosis of this lung disease may depend more on controlling excessive inflammation and repairing damaged lung than on fibrosis, and transforming growth factor-beta 1 may play a key role in this process.

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Section: Discussionmentioning

confidence: 82%

Section: Introductionmentioning

confidence: 99%

Transforming growth factor‐beta 1 in humidifier disinfectant‐associated children's interstitial lung disease

Kim

Lee

et al. 2015

Pediatric Pulmonology

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“…Acute lung injury (ALI) and its severe form, acute respiratory distress syndrome (ARDS), were first described in 1967 by Ashbaugh et al [1] in patients with acute onset of tachypnea and hypoxia and the loss of compliance after a variety of stimuli [2–5]. According to the American-European Consensus Conference (AECC) ARDS was recognized as the most severe form of acute lung injury (ALI), a form of diffuse alveolar injury.…”

Section: Introductionmentioning

confidence: 99%

Potential Effects of Medicinal Plants and Secondary Metabolites on Acute Lung Injury

Favarin

Oliveira

et al. 2013

BioMed Research International

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Acute lung injury (ALI) is a life-threatening syndrome that causes high morbidity and mortality worldwide. ALI is characterized by increased permeability of the alveolar-capillary membrane, edema, uncontrolled neutrophils migration to the lung, and diffuse alveolar damage, leading to acute hypoxemic respiratory failure. Although corticosteroids remain the mainstay of ALI treatment, they cause significant side effects. Agents of natural origin, such as medicinal plants and their secondary metabolites, mainly those with very few side effects, could be excellent alternatives for ALI treatment. Several studies, including our own, have demonstrated that plant extracts and/or secondary metabolites isolated from them reduce most ALI phenotypes in experimental animal models, including neutrophil recruitment to the lung, the production of pro-inflammatory cytokines and chemokines, edema, and vascular permeability. In this review, we summarized these studies and described the anti-inflammatory activity of various plant extracts, such as Ginkgo biloba and Punica granatum, and such secondary metabolites as epigallocatechin-3-gallate and ellagic acid. In addition, we highlight the medical potential of these extracts and plant-derived compounds for treating of ALI.

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“…Lung function testing has always been central to the diagnosis and treatment of respiratory disease and, similar to 2012, continued to be a considerable research focus in 2013. While there is an ongoing drive to improve reference values for spirometry, this is not necessarily the case for other less common lung function measures.…”

Section: Pulmonary Physiologymentioning

confidence: 99%

Year in review 2013: Acute lung injury, interstitial lung diseases, sleep and physiology

et al. 2014

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Year in review 2012: Acute lung injury, interstitial lung diseases, sleep and physiology

Cited by 8 publications

References 91 publications

Transforming growth factor‐beta 1 in humidifier disinfectant‐associated children's interstitial lung disease

Transforming growth factor‐beta 1 in humidifier disinfectant‐associated children's interstitial lung disease

Potential Effects of Medicinal Plants and Secondary Metabolites on Acute Lung Injury

Year in review 2013: Acute lung injury, interstitial lung diseases, sleep and physiology

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