Year in review in Intensive Care Medicine 2012: III. Noninvasive ventilation, monitoring and patient–ventilator interactions, acute respiratory distress syndrome, sedation, paediatrics and miscellanea

Antonelli, Massimo; Bonten, Marc J. M.; Cecconi, Maurizio; Chastre, Jean; Citerio, Giuseppe; Conti, Giorgio; Curtis, J. Randall; Hedenstierna, Göran; Joannidis, Michael; MacRae, Duncan; Maggiore, Salvatore Maurizio; Mancebo, Jordi; Mebazaa, Alexandre; Preiser, Jean‐Charles; Rocco, Patricia R. M.; Timsit, Jean‐François; Wernerman, Jan; Zhang, Haibo

doi:10.1007/s00134-012-2807-6

Cited by 14 publications

(6 citation statements)

References 90 publications

(101 reference statements)

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“…We believe Ped-RESCUERS has three potential applications. First, it can be used to provide risk-adjusted internal and external benchmarking of ECMO performance quality to centers that participate in ELSO [36]. Benchmarking is needed to characterize the substantial, clinically meaningful variation in hospital-level mortality rates [37].…”

Section: Discussionmentioning

confidence: 99%

Development and validation of the pediatric risk estimate score for children using extracorporeal respiratory support (Ped-RESCUERS)

et al. 2016

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Section: Discussionmentioning

confidence: 99%

Development and validation of the pediatric risk estimate score for children using extracorporeal respiratory support (Ped-RESCUERS)

et al. 2016

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“…It is essential to clarify the diagnosis of ARDS and to initiate effective treatments such as low tidal volume and prone positioning to improve clinical outcome [ 10 – 12 ]. The current clinical definition of ARDS reflects only nonspecific functional or physiological abnormalities rather than pathological abnormality.…”

Section: Introductionmentioning

confidence: 99%

Diffuse alveolar damage associated mortality in selected acute respiratory distress syndrome patients with open lung biopsy

Kao

Chang

et al. 2015

Crit Care

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IntroductionDiffuse alveolar damage (DAD) is the pathological hallmark of acute respiratory distress syndrome (ARDS), however, the presence of DAD in the clinical criteria of ARDS patients by Berlin definition is little known. This study is designed to investigate the role of DAD in ARDS patients who underwent open lung biopsy.MethodsWe retrospectively reviewed all ARDS patients who met the Berlin definition and underwent open lung biopsy from January 1999 to January 2014 in a referred medical center. DAD is characterized by hyaline membrane formation, lung edema, inflammation, hemorrhage and alveolar epithelial cell injury. Clinical data including baseline characteristics, severity of ARDS, clinical and pathological diagnoses, and survival outcomes were analyzed.ResultsA total of 1838 patients with ARDS were identified and open lung biopsies were performed on 101 patients (5.5 %) during the study period. Of these 101 patients, the severity of ARDS on diagnosis was mild of 16.8 %, moderate of 56.5 % and severe of 26.7 %. The hospital mortality rate was not significant difference between the three groups (64.7 % vs 61.4 % vs 55.6 %, p = 0.81). Of the 101 clinical ARDS patients with open lung biopsies, 56.4 % (57/101) patients had DAD according to biopsy results. The proportion of DAD were 76.5 % (13/17) in mild, 56.1 % (32/57) in moderate and 44.4 % (12/27) in severe ARDS and there is no significant difference between the three groups (p = 0.113). Pathological findings of DAD patients had a higher hospital mortality rate than non-DAD patients (71.9 % vs 45.5 %, p = 0.007). Pathological findings of DAD (odds ratio: 3.554, 95 % CI, 1.385–9.12; p = 0.008) and Sequential Organ Failure Assessment score on the biopsy day (odds ratio: 1.424, 95 % CI, 1.187–1.707; p<0.001) were significantly and independently associated with hospital mortality. The baseline demographics and clinical characteristics were not significantly different between DAD and non-DAD patients.ConclusionsThe correlation of pathological findings of DAD and ARDS diagnosed by Berlin definition is modest. A pathological finding of DAD in ARDS patients is associated with hospital mortality and there are no clinical characteristics that could identify DAD patients before open lung biopsy.

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“…Of the limited studies on septic ELBW infants, the cardiovascular function is mainly assessed by echocardiography (29). Noninvasive cardiac monitoring is an emerging technique that has been studied and validated in adults and infants (19,(30)(31)(32)(33)(34). To our knowledge, this is the first study examining noninvasive cardiac monitoring in septic ELBW neonates.…”

Section: Discussionmentioning

confidence: 99%

Heart Rate Variability Analysis Is More Sensitive At Identifying Neonatal Sepsis Than Conventional Vital Signs

Mrazek

Shabana

Radhakrishnan

et al. 2014

Journal of Surgical Research

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Year in review in Intensive Care Medicine 2012: III. Noninvasive ventilation, monitoring and patient–ventilator interactions, acute respiratory distress syndrome, sedation, paediatrics and miscellanea

Cited by 14 publications

References 90 publications

Development and validation of the pediatric risk estimate score for children using extracorporeal respiratory support (Ped-RESCUERS)

Development and validation of the pediatric risk estimate score for children using extracorporeal respiratory support (Ped-RESCUERS)

Diffuse alveolar damage associated mortality in selected acute respiratory distress syndrome patients with open lung biopsy

Heart Rate Variability Analysis Is More Sensitive At Identifying Neonatal Sepsis Than Conventional Vital Signs

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