Year in review in Intensive Care Medicine 2011: I. Nephrology, epidemiology, nutrition and therapeutics, neurology, ethical and legal issues, experimentals

Epidemiology of Acute Kidney Injury in Moroccan Medical Intensive Care Patients: A Regional Prospective, Observational Study

“…[28] The sepsis and septic shock represent the most frequent causes of morbidity and mortality in the ICU. [1] The multicentre European Sepsis Occurrence in Acutely Ill Patients (SOAP) study found that 51% of septic patients developed AKI. [29] More recently, in a 1-day point prevalence survey for severe sepsis/septic shock from 454 ICUs in Germany, concomitant AKI was reported in 41.4% of septic patients.…”

“…The incidence and mortality of acute kidney injury (AKI) continues to rise during hospital admission. [1][2][3][4][5][6] The variety of definitions used in clinical studies may be partially responsible for the large variations in the reported incidence and the associated mortality of AKI. [7][8][9][10] There was no controlled data about the epidemiology of AKI in medical critically ill patients in our regional hospital.…”

Fluid resuscitation with 6 % hydroxyethyl starch (130/0.4 and 130/0.42) in acutely ill patients: systematic review of effects on mortality and treatment with renal replacement therapy

“…Recent guidelines from the European Society of Intensive Care Medicine taskforce on colloid volume therapy in critically ill patients recommended against the use of 6%HES130 in patients with severe sepsis or at risk of acute kidney injury [3]. The strength of these recommendations may be limited as previous meta-analyses have relied on the results of trials that were generally poor in quality and which reported few patient-centred outcomes [2][3][4][5][6][7][8][9].…”

Whole-blood neutrophil gelatinase-associated lipocalin to predict adverse events in acute kidney injury: A prospective observational cohort study

“…The latter study included many septic patients, who might have had non-kidney-related NGAL elevations associated with critical illness and inflammation, an association supported by other studies [29,30]. Neutrophil gelatinase-associated lipocalin has also been found to be elevated in other forms of organ dysfunction, including acute heart failure [31], hepatorenal syndrome [32,33], severe sepsis, and septic shock [34,35], as well as serving as a marker of increased illness severity [34,36].…”