Year-round element quantification of a wide-ranging seabird and their relationships with oxidative stress, trophic ecology, and foraging patterns

Laranjeiro, Maria I.; Alves, Luís M.F.; Silva, Joana M. da; Pereira, Jorge M.; Norte, Ana Cláudia; Paiva, Vítor H.; Lemos, Marco F.L.; Ramos, Jaime A.; Novais, Sara C.; Ceia, Filipe R.

doi:10.1016/j.envpol.2021.117502

Cited by 6 publications

(3 citation statements)

References 86 publications

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“…Cadmium pollution has become a global problem, and it enters organisms in the form of divalent metal ions mainly through food, water, and air. 31 This study carried out subchronic toxicological experiments on chickens and first explored the root cause of neurotoxicity caused by cadmium and identified the potential target for the treatment of neurodegeneration. These results provide a deep insight into the Cd-caused neurotoxicity from a prospect of the interdependence among gap junction protein Cx43 internalization, lesion in the striatum, transition of A1-like astrocytes, autophagy, and inflammatory response.…”

Section: Discussionmentioning

confidence: 99%

“…Cadmium pollution has become a global problem, and it enters organisms in the form of divalent metal ions mainly through food, water, and air . This study carried out subchronic toxicological experiments on chickens and first explored the root cause of neurotoxicity caused by cadmium and identified the potential target for the treatment of neurodegeneration.…”

Section: Discussionmentioning

confidence: 99%

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Cadmium Transforms Astrocytes into the A1 Subtype via Inducing Gap Junction Protein Connexin 43 into the Nucleus

Zhao

Tang

et al. 2023

J. Agric. Food Chem.

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Cadmium is highly toxic and present in the environment and can be accumulated among various levels of the food chain. Both humans and animals are at risk from toxicity associated with cadmium. However, the neurological endpoint caused by cadmium has not been revealed. The aim of our research is to explore the potential target of cadmium attack when causing neurotoxicity. 80 male chickens (one day old, weighing 36.49 ± 2.88 g) were randomly divided into four groups and independently treated with 0, 35, 70, or 140 mg/kg CdCl 2 in diet for 90 days. The result showed that the striatum was damaged due to a high dose of cadmium in the brain, which was characterized by degeneration of neurons and astrocyte dysfunction. Transcriptome analysis demonstrated that striatal astrocytes were transformed into the A1 state under cadmium exposure. Deeper investigation revealed that the internalization of gap junction protein connexin 43 was responsible for this transformation. Eventually, we can conclude that the internalized gap junction protein connexin 43 of astrocytes is the target of cadmium anchoring, and this process was accompanied by the transformation of astrocytes into the A1 subtype. This study provides a new direction for exploring the effects of cadmium on the nervous system and the treatment of subsequent nervous system diseases.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Cadmium Transforms Astrocytes into the A1 Subtype via Inducing Gap Junction Protein Connexin 43 into the Nucleus

Zhao

Tang

et al. 2023

J. Agric. Food Chem.

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“…Evidently, most of the uses of this biomarker tool goes to laboratorial assessment of biotic and abiotic factors, but a big share of studies account for the impacts of global changes on wildlife, with applicability in fishes (e.g., [ 66 , 67 , 68 ]), birds (e.g., [ 69 , 70 ]), turtles (e.g., [ 71 , 72 ]), or terrestrial and marine mammals (e.g., [ 73 , 74 ]), to name a few. The use of biomarkers is not limited to the realm of environmental sciences, that is a fact, and is (and should be) used increasingly to understand mechanisms that can lead to a better commercial use of organisms.…”

Section: Applications and Perspectivesmentioning

confidence: 99%

Biomarker Studies in Stress Biology: From the Gene to Population, from the Organism to the Application

Lemos

2021

Biology

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Endpoints assessed at the population or community level are most often the result of the sum of effects on individuals, arising from the effects at the cellular and molecular levels. Within this framework, these lower biological level endpoints are more responsive at an early stage of exposure, making them potential toolboxes to be used as early-warning markers to address stress. Given this, by linking responses and understanding organisms’ metabolism and physiology, the possibilities for the use of biomarkers in stress biology are vast. Here, biomarker comprehensive examples are given to enlighten the need to link levels of biological organization, and their usefulness for a myriad of fields and applications is presented and discussed.

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Paint particles on aquatic organisms: An emerging issue of contamination

Ceia,

Bessa

2024

Microplastic Contamination in Aquatic Environments

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Year-round element quantification of a wide-ranging seabird and their relationships with oxidative stress, trophic ecology, and foraging patterns

Cited by 6 publications

References 86 publications

Cadmium Transforms Astrocytes into the A1 Subtype via Inducing Gap Junction Protein Connexin 43 into the Nucleus

Cadmium Transforms Astrocytes into the A1 Subtype via Inducing Gap Junction Protein Connexin 43 into the Nucleus

Biomarker Studies in Stress Biology: From the Gene to Population, from the Organism to the Application

Paint particles on aquatic organisms: An emerging issue of contamination

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