Yearly variations of the genetic structure of Aedes aegypti (Linnaeus) (Diptera: Culicidae) in the Philippines (2017–2019)

Edillo, Frances E.; Ymbong, Rhoniel Ryan; Cabahug, Maureen Mathilde; Labiros, Dinesse A; Suycano, Mark Windy; Lambrechts, Louis; Sakuntabhai, Anavaj

doi:10.1016/j.meegid.2022.105296

Cited by 3 publications

(1 citation statement)

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“…Climate change affects the survival and dispersion of Aedes aegypti and Aedes albopictus and transmission rates of viral pathogens of dengue [24], yet it was recommended to change vector control strategies during the epidemic wet seasons into a whole year to optimize the economic cost and burden of dengue and other arboviral diseases. [25] One of the effective ways to prevent the spread of dengue is the installation of water pipelines to residents in rural mountains to prevent mosquitoes from breeding in stored water [25,26]. Besides, the dengue vaccine in Philippines, called Dengvaxia, which had a pooled efficacy amounting to 65.6% decrease in dengue with symptoms in people aged nine or older, could also serve as way of preventing dengue fever [27,28].…”

Section: Discussionmentioning

confidence: 99%

Incidence and mortality trends of neglected tropical diseases and malaria in China and ASEAN countries from 1990 to 2019 and its association with the socio-demographic index

Yan

Qin

et al. 2023

glob health res policy

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Background People in China and the countries in the Association of Southeast Asian Nations (ASEAN) are affected by neglected tropical diseases and malaria (NTDM). In this study, we aimed to assess the current status and trends of NTDM burden from 1990 to 2019 in China and ASEAN countries, and also explore the association of NTDM burden with socio-demographic index (SDI). Methods The data from the Global Burden of Diseases Study 2019 (GBD 2019) results were used. Absolute incidence and death number, and age-standardized incidence and mortality rate (ASIR and ASMR) of NTDM in China and ASEAN were extracted. The estimated annual percentage change (EAPC) and join-point regression in the rates quantified the trends. Nonlinear regression (second order polynomial) was used to explore the association between SDI and ASRs. Results The ASIR of NTDM increased in China, Philippines, Singapore and Brunei, at a speed of an average 4.15% (95% CI 3.83–4.47%), 2.15% (1.68–2.63%), 1.03% (0.63–1.43%), and 0.88% (0.60–1.17%) per year. Uptrends of ASIR of NTDM in recent years were found in China (2014–2017, APC = 10.4%), Laos (2005–2013, APC = 3.9%), Malaysia (2010–2015, APC = 4.3%), Philippines (2015–2019, APC = 4.2%), Thailand (2015–2019, APC = 2.4%), and Vietnam (2014–2017, APC = 3.2%, all P < 0.05). Children < 5 had relatively low incidences but unexpectedly high mortality rates of NTDM in most ASEAN countries. Both incidence and mortality rates of NTDM were higher in older people. ASIR and ASMR of NTDM had a U-shaped association with SDI. Conclusions The burden of NTDM in China and ASEAN countries was still huge and affects vulnerable and impoverished populations’ livelihoods, including children under the age of 5 and people aged 60 and older. Facing with the large burden and complex situation of NTDM in China and ASEAN countries, regional cooperating strategies are needed to reduce the burden of NTDM, so as to achieve the goal of elimination in the world.

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Section: Discussionmentioning

confidence: 99%

Incidence and mortality trends of neglected tropical diseases and malaria in China and ASEAN countries from 1990 to 2019 and its association with the socio-demographic index

Yan

Qin

et al. 2023

glob health res policy

View full text Add to dashboard Cite

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Detecting the impacts of humidity, rainfall, temperature, and season on chikungunya, dengue and Zika viruses in Aedes albopictus mosquitoes from selected sites in Cebu city, Philippines

Edillo,

Ymbong,

Navarro

et al. 2024

Virol J

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Background Aedes albopictus is the secondary vector for dengue virus (DENV) in the Philippines, and also harbors chikungunya (CHIKV) and Zika (ZIKV) viruses. This study aimed to determine the minimum infection rates (MIRs) of CHIKV, DENV serotypes, and ZIKV in Ae. albopictus collected from selected two-site categories by altitude (highland [H] and lowland [L] sites) in Cebu city, Philippines during the wet (WS) and dry seasons (DS) of 2021–2022, and to explore the relationships between these arboviral MIRs and the local weather. Methods The viral RNA extracts in pooled and reared adult Ae. albopictus collected during the DS and WS from two-site categories were subjected to RT-PCR to amplify and detect gene loci specific for CHIKV, DENV-1 to DENV-4, and ZIKV and analyzed with the weather data. Results The range of CHIKV MIRs was higher in the WS (13.61–107.38 infected individuals per 1,000 mosquitoes) than in the DS (13.22–44.12), but was similar between the two-site categories. Rainfall (RF) influenced the CHIKV MIR. The MIR ranges of both DENV-2 (WS: H = 0, L = 0; DS: H = 0–5.92; L = 0–2.6) and DENV-4 (WS: H = 0, L = 0–2.90; DS: H = 2.96–6.13, L = 0–15.63) differed by season but not between the two-site categories. Relative humidity (RH), RF, and temperature did not influence DENVs’ MIRs. The MIR range of ZIKV was similar in both seasons (WS: 11.36–40.27; DS: 0–46.15) and two-site categories (H = 0–90.91, L = 0–55.56). RH and temperature influenced ZIKV MIR. Conclusions RF influenced CHIKV MIR in Ae. albopictus, whereas RH and temperature influenced that of ZIKV. Season influenced the MIRs of CHIKV and DENVs but not in ZIKV. Ae. albopictus were co-infected with CHIKV, DENVs, and ZIKV in both highland and lowland sites in Cebu city. Recommendations include all-year-round implementation of the Philippine Department of Health’s 4S enhanced strategy and installation of water pipelines in rural highlands for vector and disease control. Our findings are relevant to protect public health in the tropics in this climate change.

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Development of microsatellite markers for the invasive mosquito Aedes koreicus

et al. 2023

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Background Aedes koreicus is a mosquito species native to East Asia which has recently invaded several countries in Europe. In Italy, this mosquito was first detected in the North-East in 2011 and is now widely distributed in the entire northern part of the country. The development of specific genetic markers, such as microsatellites, is necessary to uncover the dispersal routes of this mosquito from its native areas and, eventually, to plan future control interventions. Methods Available raw sequences of genomic DNA of Ae. koreicus were screened in silico using BLASTn to identify possible microsatellite-containing sequences. Specific primer pairs were then designed, and their efficiency was determined through polymerase chain reaction (PCR) on 32 individuals of Ae. koreicus collected in Italy. PCR conditions were optimised in three multiplex reactions. Genotyping of individual mosquitoes was performed on both single and multiplex PCR reactions. Finally, analysis of intra-population variation was performed to assess the level of polymorphism of the markers. Results Mosquito genotyping provided consistent results in both single and multiplex reactions. Out of the 31 microsatellite markers identified in the Ae. koreicus genome raw sequences, 11 were polymorphic in the examined mosquito samples. Conclusions The results show that the 11 microsatellite markers developed here hold potential for investigating the genetic structure of Ae. koreicus populations. These markers could thus represent a novel and useful tool to infer the routes of invasion of this mosquito species into Europe and other non-native areas. Graphical Abstract

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Yearly variations of the genetic structure of Aedes aegypti (Linnaeus) (Diptera: Culicidae) in the Philippines (2017–2019)

Cited by 3 publications

References 76 publications

Incidence and mortality trends of neglected tropical diseases and malaria in China and ASEAN countries from 1990 to 2019 and its association with the socio-demographic index

Incidence and mortality trends of neglected tropical diseases and malaria in China and ASEAN countries from 1990 to 2019 and its association with the socio-demographic index

Detecting the impacts of humidity, rainfall, temperature, and season on chikungunya, dengue and Zika viruses in Aedes albopictus mosquitoes from selected sites in Cebu city, Philippines

Development of microsatellite markers for the invasive mosquito Aedes koreicus

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