Yeast ABC proteins involved in multidrug resistance

Piecuch, Agata; Obłąk, Ewa

doi:10.2478/s11658-013-0111-2

Cited by 30 publications

(31 citation statements)

References 89 publications

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“…These ABC transporter proteins have similar trans-membrane domains that can pump the chemotherapeutic drugs out of cancer cells against a concentration gradient in an ATP energy-dependent manner, thus reducing intracellular accumulation of chemotherapeutic agents, and protecting cancer cells from toxicity. To date, 48 ABC transporters have been detected in the human body 8 , among which the most extensively characterized MDR transporters include P-glycoprotein (P-gp/ABCB1), multidrug resistance associated protein-1 (MRP1/ABCC1), and breast cancer resistant proteins (BCRP/ABCG2)9, 10, 11.…”

Section: Mechanisms Of Multidrug Resistancementioning

confidence: 99%

Regulation of multidrug resistance by microRNAs in anti-cancer therapy

An¹,

Sarmiento

Tan

et al. 2017

Acta Pharmaceutica Sinica B

168

132

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Multidrug resistance (MDR) remains a major clinical obstacle to successful cancer treatment. Although diverse mechanisms of MDR have been well elucidated, such as dysregulation of drugs transporters, defects of apoptosis and autophagy machinery, alterations of drug metabolism and drug targets, disrupti on of redox homeostasis, the exact mechanisms of MDR in a specific cancer patient and the cross-talk among these different mechanisms and how they are regulated are poorly understood. MicroRNAs (miRNAs) are a new class of small noncoding RNAs that could control the global activity of the cell by post-transcriptionally regulating a large variety of target genes and proteins expression. Accumulating evidence shows that miRNAs play a key regulatory role in MDR through modulating various drug resistant mechanisms mentioned above, thereby holding much promise for developing novel and more effective individualized therapies for cancer treatment. This review summarizes the various MDR mechanisms and mainly focuses on the role of miRNAs in regulating MDR in cancer treatment.

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Section: Mechanisms Of Multidrug Resistancementioning

confidence: 99%

Regulation of multidrug resistance by microRNAs in anti-cancer therapy

An¹,

Sarmiento

Tan

et al. 2017

Acta Pharmaceutica Sinica B

168

132

View full text Add to dashboard Cite

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“…The result emphasizes the greater influence and contribution of Cacdr1p compared to CaCdr2p in resistance and antifungal therapy failure (Holmes et al, 2008; Piecuch and Obłak, 2014). …”

Section: The Atp-binding Cassette (Abc)mentioning

confidence: 94%

The Role of Eukaryotic and Prokaryotic ABC Transporter Family in Failure of Chemotherapy

Saleh²,

et al. 2017

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Over the years chemotherapy failure has been a vital research topic as researchers have been striving to discover reasons behind it. The extensive studies carried out on chemotherapeutic agents confirm that resistance to chemotherapy is a major reason for treatment failure. “Resistance to chemotherapy,” however, is a comprehensive phrase that refers to a variety of different mechanisms in which ATP-binding cassette (ABC) mediated efflux dominates. The ABC is one of the largest gene superfamily of transporters among both eukaryotes and prokaryotes; it represents a variety of genes that code for proteins, which perform countless functions, including drug efflux – a natural process that protects cells from foreign chemicals. Up to date, chemotherapy failure due to ABC drug efflux is an active research topic that continuously provides further evidence on multiple drug resistance (MDR), aiding scientists in tackling and overcoming this issue. This review focuses on drug resistance by ABC efflux transporters in human, viral, parasitic, fungal and bacterial cells and highlights the importance of the MDR permeability glycoprotein being the mutual ABC transporter among all studied organisms. Current developments and future directions to overcome this problem are also discussed.

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“…ABC (ATP-binding cassette) transporters are a family of transmembrane proteins that can transport various substrates, including chemotherapeutic drugs, across extra-and intra-cellular membranes against a concentration gradient in an ATP energy-dependent manner. P-gp, MDR-associated protein (MRP) and breast cancer resistance protein (BCRP) are the three major members of ABC that are closely related to MDR [14,15]. Current evidence demonstrates that miRNAs can regulate the expression of certain protein coding genes of the ABC family in a posttranslational manner [16].…”

Section: Mirnas Regulate Drug Transporter-related Proteinsmentioning

confidence: 99%