Yeast biofilms on abiotic surfaces: Adhesion factors and control methods

Alonso, Vanessa Pereira Perez; Lemos, Jéssica Gonçalves; Nascimento, Maristela da Silva do

doi:10.1016/j.ijfoodmicro.2023.110265

Cited by 8 publications

(2 citation statements)

References 124 publications

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“…A biofilm is a densely packed population of microbial cells, that are adhered to a solid surface or living tissue, are surrounded by extracellular polymers, and have properties that distinguish them from their free-floating counterparts [63,64]. Candida has a remarkable ability to develop biofilms on surfaces such as catheters, dentures, and other implants [65].…”

Section: Candida Biofilm Developmentmentioning

confidence: 99%

Antifungal drug resistance in Candida: a special emphasis on amphotericin B

Ahmady,

Gothwal,

Mukkoli

et al. 2024

APMIS

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Invasive fungal infections in humans caused by several Candida species, increased considerably in immunocompromised or critically ill patients, resulting in substantial morbidity and mortality. Candida albicans is the most prevalent species, although the frequency of these organisms varies greatly according to geographic region. Infections with C. albicans and non‐albicans Candida species have become more common, especially in the past 20 years, as a result of aging, immunosuppressive medication use, endocrine disorders, malnourishment, extended use of medical equipment, and an increase in immunogenic diseases. Despite C. albicans being the species most frequently associated with human infections, C. glabrata, C. parapsilosis, C. tropicalis, and C. krusei also have been identified. Several antifungal drugs with different modes of action are approved for use in clinical settings to treat fungal infections. However, due to the common eukaryotic structure of humans and fungi, only a limited number of antifungal drugs are available for therapeutic use. Furthermore, drug resistance in Candida species has emerged as a result of the growing use of currently available antifungal drugs against fungal infections. Amphotericin B (AmB), a polyene class of antifungal drugs, is mainly used for the treatment of serious systemic fungal infections. AmB interacts with fungal plasma membrane ergosterol, triggering cellular ion leakage via pore formation, or extracting the ergosterol from the plasma membrane inducing cellular death. AmB resistance is primarily caused by changes in the content or structure of ergosterol. This review summarizes the antifungal drug resistance exhibited by Candida species, with a special focus on AmB.

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Section: Candida Biofilm Developmentmentioning

confidence: 99%

Antifungal drug resistance in Candida: a special emphasis on amphotericin B

Ahmady,

Gothwal,

Mukkoli

et al. 2024

APMIS

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“…Yeast exist as part of microbial communities, including colonies, biofilms [24] and “mats” [25, 26, 27, 28, 29]. A yeast mat is a morphologically complex, colony-like structure that requires the expression of the flocculin gene flo11 , which encodes the Flo11 surface adhesion protein.…”

Section: Introductionmentioning

confidence: 99%

A Novel Magnetic Field Device: Effects of Magnetic Fields on Planktonic Yeasts and Fungal Mats

Bandara,

Li,

Charlebois

2024

Preprint

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Microorganisms evolved within the geomagnetic field and can be affected by magnetic field exposure. However, the mechanisms underlying many magnetic phenomena in microbes remain to be elucidated. We develop a 3D-printed magnetic field exposure device to perform experiments on microbes. This device is designed in AutoCAD, modeled in COMSOL, and validated using a Gaussmeter. Using the magnetic field exposure device, we perform static magnetic field experiments on different strains of the budding yeastSaccharomyces cerevisiae. We find that static magnetic field exposure slows the spatially-structured expansion of yeast mats that expands in two dimensions, but not yeast mats that expand in three dimensions, across the surface of semi-solid media. We also find that magnetic fields do not affect the growth of yeast cells in well-mixed liquid media. This study provides a novel device for magnetic field exposure experiments on microorganisms and advances our understanding of the effects of magnetic fields on fungi.

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