2018
DOI: 10.1242/jcs.209114
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Yeast Hog1 proteins are sequestered in stress granules during high-temperature stress

Abstract: The yeast high-osmolarity glycerol (HOG) pathway plays a central role in stress responses. It is activated by various stresses, including hyperosmotic stress, oxidative stress, high-temperature stress and exposure to arsenite. Hog1, the crucial MAP kinase of the pathway, localizes to the nucleus in response to high osmotic concentrations, i.e. high osmolarity; but, otherwise, little is known about its intracellular dynamics and regulation. By using the methylotrophic yeast , we found that CbHog1-Venus formed i… Show more

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Cited by 13 publications
(4 citation statements)
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“…Therefore, it is possible that weak Hog1 phosphorylation resulted in irreversible activation of different cellular signaling processes in the cytoplasm. Recently, cytosolic localization of Hog1 was also reported following heat stress (Shiraishi et al, 2017). Among the interacting partners of the dynactin complex, Bzz1, but none of the other interacting Fig.…”
Section: Discussionmentioning
confidence: 94%
“…Therefore, it is possible that weak Hog1 phosphorylation resulted in irreversible activation of different cellular signaling processes in the cytoplasm. Recently, cytosolic localization of Hog1 was also reported following heat stress (Shiraishi et al, 2017). Among the interacting partners of the dynactin complex, Bzz1, but none of the other interacting Fig.…”
Section: Discussionmentioning
confidence: 94%
“…SGs have been proposed to intercept and sequester signaling components 26 . Exposure of Candida boidinii, Pichia pastoris and Schizosaccharomyces pombe to high-temperature stress resulted in colocalization of the CbHog1 with the stress granule marker Pab1 27 . In other cases, Hog1 was found to affect cellular processes linked to SG formation, though indirectly 28 .…”
Section: Discussionmentioning
confidence: 99%
“…It is of note that SGs (i.e., cytoplasmatic granules marked by Pab1/PABP and Pbp1/Ataxin‐2) have also been observed during thermal stress (i.e., 42°C for 30 min) in Candida boidinii and Pichia pastoris (Shiraishi et al, 2018).…”
Section: Other Types Of Stress That Promote Sg Formationmentioning
confidence: 99%