Yellow fever: laboratorial diagnosis and clinical manifestations

Xavier, Analúcia Rampazzo; Freitas, Gabriela Silva; Santos, Caroline Ferreira dos; Januzzi, Werlley A.; Lacerda, Gilmar S.; Carvalho, Edimilson R. M.; Kanaan, Salim

doi:10.5935/1676-2444.20180050

Cited by 4 publications

(4 citation statements)

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“…Clinical manifestation in humans varies from mild undifferentiated febrile illness to severe disease and occurs in two phases [67]. The incubation period for YFV varies from 3 to 6 days but sometimes may go up to 14 days [47].…”

Section: Viruses Previously Involved In Disease Outbreaks In Ugandamentioning

confidence: 99%

Mosquito-borne arboviruses in Uganda: history, transmission and burden

Mayanja

Mwiine

Lutwama

et al. 2021

Journal of General Virology

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Mosquito-transmitted arboviruses constitute a large proportion of emerging infectious diseases that are both a public health problem and a threat to animal populations. Many such viruses were identified in East Africa, a region where they remain important and from where new arboviruses may emerge. We set out to describe and review the relevant mosquito-borne viruses that have been identified specifically in Uganda. We focused on the discovery, burden, mode of transmission, animal hosts and clinical manifestation of those previously involved in disease outbreaks. A search for mosquito-borne arboviruses detected in Uganda was conducted using search terms ‘Arboviruses in Uganda’ and ‘Mosquitoes and Viruses in Uganda’ in PubMed and Google Scholar in 2020. Twenty-four mosquito-borne viruses from different animal hosts, humans and mosquitoes were documented. The majority of these were from family Peribunyaviridae, followed by Flaviviridae, Togaviridae, Phenuiviridae and only one each from family Rhabdoviridae and Reoviridae. Sixteen (66.7 %) of the viruses were associated with febrile illnesses. Ten (41.7 %) of them were first described locally in Uganda. Six of these are a public threat as they have been previously associated with disease outbreaks either within or outside Uganda. Historically, there is a high burden and endemicity of arboviruses in Uganda. Given the many diverse mosquito species known in the country, there is also a likelihood of many undescribed mosquito-borne viruses. New generation diagnostic platforms have great potential to identify new viruses. Indeed, four novel viruses, two of which were from humans (Ntwetwe and Nyangole viruses) and two from mosquitoes (Kibale and Mburo viruses) including the 2010 yellow fever virus (YFV) outbreak were identified in the last decade using next generation sequencing. Given the unbiased approach of detection of viruses by this technology, its use will undoubtedly be critically important in the characterization of mosquito viromes which in turn will inform other diagnostic efforts.

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Section: Viruses Previously Involved In Disease Outbreaks In Ugandamentioning

confidence: 99%

Mosquito-borne arboviruses in Uganda: history, transmission and burden

Mayanja

Mwiine

Lutwama

et al. 2021

Journal of General Virology

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“…Other studies developed definitions with the use of similar methodology 17 . Incorporation of laboratorial results made the definition more sensitive, since transaminases alterations in serum are earlier identified than clinical manifestation of jaundice, a signal included in both case definitions (Brazil and WHO) that may be absent in some cases 18 .…”

Section: Discussionmentioning

confidence: 99%

Accuracy of yellow fever case definition of epidemiologic surveillance, São Paulo, 2018

Ribeiro,

Cavalin,

Klimas

et al. 2023

Rev. saúde pública

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OBJECTIVE: To evaluate the accuracy of yellow fever (YF) suspected case definitions from the Brazilian Ministry of Health (BMH) and World Health Organization (WHO), as well as propose and evaluate new definitions of suspected cases, considering confirmed and discarded cases. METHODS: The retrospective study was conducted at the Instituto de Infectologia Emílio Ribas (IIER), using the Epidemiologic Surveillance Form of YF cases. From the confirmed and discarded cases of YF, a logistic regression model was developed. The independent variables were used in a proposed definition of a suspected case of YF and its accuracy was evaluated. RESULTS: In total, 113 YF suspect cases were reported, with 78 confirmed (69.0%). The definitions by BMH and WHO presented low sensitivity, 59% and 53.8%, and reduced accuracy, 53.1% and 47.8%, respectively. Predictive factors for YF were thrombocytopenia, leukopenia, and elevation of transaminases greater than twice normal. The definition including individual with acute onset of fever, followed by elevation of ALT or AST greater than twice the reference value AND leukopenia OR thrombocytopenia presented high sensitivity (88.3%), specificity (62.9%), and the best accuracy (80.4%), as proposed in the model. CONCLUSION: The YF suspected case definitions of the BMH and the WHO have low sensitivity. The inclusion of nonspecific laboratory tests increases the accuracy of YF definition.

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“…Um dado clínico que pode aparecer é o chamado sinal de Faget (bradicardia acompanhada de febre elevada), entretanto, não pode ser considerado um achado específico da doença. Devemos destacar, ainda, a possibilidade de quadros assintomáticos ou oligossintomáticos, assim como o avanço da fase infecciosa diretamente para a fase toxêmica, sem passar pela etapa de remissão (Xavier et. al, 2018).…”

Section: Manifestações Clínicasunclassified

Estudos Multidisciplinares Sobre Saúde Da Criança E Do Adolescente

SOUSA¹,

BARBOSA²,

MACÊDO³

et al. 2023

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Todos os trabalhos foram avaliados pelo corpo editorial do 1º Congresso Brasileiro de Saúde da Criança e do Adolescente. O evento foi realizado de forma remota, nos dias 16, 17 e 18 de dezembro de 2022, sendo promovido pelo Instituto Academic (CNPJ: 42.698.982/0001-87). O congresso contou com a participação de vários palestrantes renomados que discutiram temáticas relevantes sobre o cuidado à saúde da criança e adolescente. O objetivo do evento foi de promover a educação, capacitação, treinamento e atualização multidisciplinar na área da saúde da criança e do adolescente, sendo destinado a discentes, docentes, profissionais de saúde e demais interessados pela discussão da temática. O e-book é composto por dezenas de estudos que abordam assuntos sobre a saúde da criança e do adolescente. Os trabalhos são frutos de pesquisas de autores de vários estados do Brasil.

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Yellow fever: laboratorial diagnosis and clinical manifestations

Cited by 4 publications

References 0 publications

Mosquito-borne arboviruses in Uganda: history, transmission and burden

Mosquito-borne arboviruses in Uganda: history, transmission and burden

Accuracy of yellow fever case definition of epidemiologic surveillance, São Paulo, 2018

Estudos Multidisciplinares Sobre Saúde Da Criança E Do Adolescente

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