Yellow fever vaccine-associated viscerotropic disease and death in Spain

Doblas, A.; Domingo, Cristina; Bae, Hi-Gung; Bohórquez, C.L.; Ory, Fernando de; Niedrig, Matthias; Mora, D.; Carrasco, Francisco Javier; Tenorio, Antonio

doi:10.1016/j.jcv.2006.02.005

Cited by 59 publications

(36 citation statements)

References 4 publications

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“…However, higher levels have been reported in wild-type infections (2,14) and severe YFVAE (4,7,13). The results presented are in agreement with these observations and deserve being thoroughly studied.…”

supporting

confidence: 89%

Detection of Yellow Fever 17D Genome in Urine

et al. 2011

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supporting

confidence: 89%

Detection of Yellow Fever 17D Genome in Urine

et al. 2011

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“…18 Strong responses in both cell-mediated and humoral responses were found in these cases and also in a fatal case in Spain. 19 As a rule, neutralizing antibody titers are high in YEL-AVD, and taken together these findings point to defects in innate response in YEL-AVD cases. Coherent with this view, the symptoms of YEL-AVD begin at a short time after vaccination in most cases.…”

Section: Vaccine-associated Viscerotropicmentioning

confidence: 90%

Serious adverse events associated with yellow fever vaccine

Martins

Leal²,

Homma³

2015

Human Vaccines & Immunotherapeutics

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“…Desde 1937, a vacina de vírus vivo atenuado tem protegido aproximadamente 400 milhões de pessoas em todo o mundo 8 . Dentro de 30 dias, mais de 90% dos vacinados desenvolvem anticorpos contra a febre amarela 23 .…”

Section: Mota Lmh Colsunclassified

Vacinação contra febre amarela em pacientes com diagnósticos de doenças reumáticas, em uso de imunossupressores

Mota

Oliveira

Lima

et al. 2009

Rev. Soc. Bras. Med. Trop.

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A febre amarela é uma doença viral, infecciosa não-contagiosa, endêmica em regiões da África e da América do Sul. É transmitida pela picada de insetos hematófagos da família Culicidae, em especial dos gêneros Aedes e Haemagogus 22 . Vacinação contra febre amarela em pacientes com diagnósticos de doenças reumáticas, em uso de imunossupressores ABSTRACTYellow fever is endemic in some countries. The anti-yellow fever vaccine is the only effective means of protection but is contraindicated for immunocompromised patients. The aim of this paper was to report on a case series of rheumatological patients who were using immunosuppressors and were vaccinated against this disease. This was a retrospective study by means of a questionnaire applied to these patients, who were vaccinated 60 days before the investigation. Seventy patients of mean age 46 years were evaluated. Most of them were female (90%). There were cases of rheumatoid arthritis (54), systemic lupus erythematosus (11), spondyloarthropathy (5) and systemic sclerosis (2). The therapeutic schemes included methotrexate (42), corticosteroids (22), sulfasalazine (26), leflunomide (18), cyclophosphamide (3) and immunobiological agents (9). Sixteen patients (22.5%) reported some minor adverse effect. Among the eight patients using immunobiological agents, only one presented a mild adverse effect. Among these patients using immunosuppressors, adverse reactions were no more frequent than among immunocompetent individuals. This is the first study on this topic. A suscetibilidade é geral e irrestrita, não havendo distinção de raça, idade ou gênero. As manifestações clínicas variam desde um quadro febril leve à infecção grave, acarretando falência renal e hepática, dano cardíaco, hemorragia e choque 23 . Estima-se que apenas 10% sejam formas graves, associadas à elevada letalidade, variando de 20-50% dos casos 1 22 . Não há tratamento específico para a doença. Key

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Yellow fever vaccine-associated viscerotropic disease and death in Spain

Cited by 59 publications

References 4 publications

Detection of Yellow Fever 17D Genome in Urine

Detection of Yellow Fever 17D Genome in Urine

Serious adverse events associated with yellow fever vaccine

Vacinação contra febre amarela em pacientes com diagnósticos de doenças reumáticas, em uso de imunossupressores

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