Yerba mate (Ilex paraguariensis) microparticles modulate antioxidant markers in the plasma and brains of rats

Vargas, Bruna Krieger; Frota, Elionio Galvão; Santos, Lára Franco dos; Gutkoski, Júlia Pedó; Lopes, Samuel Teixeira; Bertol, Charise Dallazem; Bertolin, Telma Elita

doi:10.1016/j.fbio.2021.100999

Cited by 10 publications

(2 citation statements)

References 74 publications

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“…All of these results show a relation to the antioxidant potential of Ilex paraguariensis, which is widely described in the literature [ 2 , 3 , 36 , 37 , 38 , 39 ], even after the microencapsulation process [ 40 , 41 , 42 ]. In addition, the efficiency of the encapsulation process of Ilex paraguariensis is considered stable with the wall product used (maltodextrin gum Arabic).…”

Section: Discussionsupporting

confidence: 54%

Deferoxamine Supplementation Abolished Iron-Related Toxicity of Ilex paraguariensis Extract: Behavioral and Biochemical Evaluation in Adult Zebrafish (Danio rerio)

et al. 2022

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Ilex paraguariensis (Herb mate) is a native plant from South America, widely consumed through the infusion of dried leaves. The presence of antioxidant properties in herb mate may be relevant and contribute to evaluating the effect of its compounds against oxidative stress, which could cause neurodegenerative diseases. Despite having health benefits, there are reports of the presence of heavy metals in extracts obtained from the infusion. One of these metals is iron (Fe), found in large amounts in herb mate. To reverse the cumulative effects of metals and Fe in the body, the use of Deferoxamine (Dfx) is indicated, being a potent chelator of Fe. In this work, we aimed to evaluate the antioxidant potential of the micro-encapsulated extract of I. paraguariensis (MEIP) supplemented with Dfx on zebrafish behavior and biochemical biomarkers. To evaluate the effect per se and the supplementation, four groups were established: the first group was the control (water); the second, fish treated with MEIP; the third group was formed of fish treated with Dfx; while the fourth group was treated with both MEIP and Dfx. When applied alone, Dfx presents an anxiogenic-like pattern on zebrafish (Danio rerio), while the MEIP shows an anxiolytic-like behavior. The antioxidant enzymes are re-modulated close to control when the MEIP + Dfx is applied. The cholinergic system shows an activation of the signaling, as well as the heme radical group formation, which is not affected by the Dfx-chelating effect. Thus, the supplementation of MEIP with Dfx is important to transform this extract into one that is safer and healthier for human consumption.

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Section: Discussionsupporting

confidence: 54%

Deferoxamine Supplementation Abolished Iron-Related Toxicity of Ilex paraguariensis Extract: Behavioral and Biochemical Evaluation in Adult Zebrafish (Danio rerio)

et al. 2022

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“…When microencapsulating the yerba mate freeze-dried extract by ionic gelation, Vargas et al [ 44 ] had particle sizes equal to 180.43 μm (D50), with polydispersity index of 1.75. Gelation was conducted through a solution of sodium alginate and freeze-dried extract atomized in calcium chloride.…”

Section: Resultsmentioning

confidence: 99%

Stability of yerba mate extract, evaluation of its microencapsulation by ionic gelation and fluidized bed drying

Budin¹,

Takano

Alvim³

et al. 2023

Heliyon

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The Neuroprotective Effect of Rooibos Herbal Tea Against Alzheimer's Disease: A Review

Chipofya,

Docrat,

Marnewick

2024

Molecular Nutrition Food Res

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The world is experiencing a demographic shift toward an increasing proportion of elderly persons. Alzheimer's disease (AD) and other neurological disorders are far more likely to develop as people age. AD is a gradual, irreversible, and degenerative brain disorder that progressively deteriorates memory and cognitive function, eventually leading to death. Treatment for AD is the most significant unmet clinical need in neurology. There are no effective treatment options to prevent or reverse the degenerative process. The current medical management focuses primarily on temporarily easing symptoms, with little or no overall improvement. Although genetic predisposition and lifestyle factors influence the risk of neurodegenerative disorders, recent research suggests that dietary polyphenols with solid antioxidant capacities play crucial roles in determining brain health and aging. Aspalathus linearis is used to produce Rooibos, a popular South African herbal tea, which may modulate neurodegenerative mechanisms such as oxidative stress, tau protein, amyloid plaques, inflammation, and metals, all of which have been associated with AD. We reviewed the literature to evaluate the potential neuroprotective effects of Rooibos and its major flavonoids and to understand the underlying molecular mechanisms.

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Yerba mate (Ilex paraguariensis) microparticles modulate antioxidant markers in the plasma and brains of rats

Cited by 10 publications

References 74 publications

Deferoxamine Supplementation Abolished Iron-Related Toxicity of Ilex paraguariensis Extract: Behavioral and Biochemical Evaluation in Adult Zebrafish (Danio rerio)

Deferoxamine Supplementation Abolished Iron-Related Toxicity of Ilex paraguariensis Extract: Behavioral and Biochemical Evaluation in Adult Zebrafish (Danio rerio)

Stability of yerba mate extract, evaluation of its microencapsulation by ionic gelation and fluidized bed drying

The Neuroprotective Effect of Rooibos Herbal Tea Against Alzheimer's Disease: A Review

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