Yerba Mate Stimulates Mitochondrial Biogenesis and Thermogenesis in High‐Fat‐Diet‐Induced Obese Mice

Santos, Tanila Wood dos; Miranda, Jonatan; Teixeira, Lucimara; Aiastui, Ana; Matheu, Ander; Gambero, Alessandra; Portillo, Marı́a P.; Ribeiro, Marcelo Lima

doi:10.1002/mnfr.201800142

Cited by 16 publications

(9 citation statements)

References 40 publications

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“…With the progress of pregnancy and rapid fetal growth, placental mitochondrial respiratory chain enzyme activity and ROS production are significantly increased . It has been demonstrated that SIRT1 is an important regulator of mitochondrial biogenesis and fatty acid oxidation, which interacts with PGC1α in various tissues and cells . In our study, it was observed that placental SIRT1 deficiency significantly decreased PGC1α mRNA and protein level.…”

Section: Discussionsupporting

confidence: 49%

Maternal Eicosapentaenoic Acid Feeding Decreases Placental Lipid Deposition and Improves the Homeostasis of Oxidative Stress Through a Sirtuin‐1 (SIRT1) Independent Manner

Peng

Xiong

Cui

et al. 2019

Molecular Nutrition Food Res

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Scope: Maternal obesity has been associated with increased placental lipotoxicity and impaired mitochondrial function. Sirtuin-1 (SIRT1) is an important regulator of both lipid metabolism and mitochondrial biogenesis. The present study aims to determine whether supplementation of the maternal diet with eicosapentaenoic acid (EPA) can decrease placental lipid deposition and improve antioxidant ability, in a SIRT1-dependent manner. Methods and results: Pregnant SIRT1 +/− mice (mated with male SIRT1 +/− ) are fed a high-fat diet consisting of 60% of the kcal from fat, or an equienergy EPA diet for 18.5 d. Supplementation with EPA significantly changes maternal plasma, placental and fetal fatty acid composition, and decreases placental and fetal lipid content. In addition, placental antioxidant capacity and lipid peroxidation products are increased, placental uncoupling protein 1 (UCP1) and PPAR coactivator-1 (PGC1 ) expression are activated, and mitochondrial swelling decreases. While SIRT1 deficiency has little effect on placental fatty acid composition and lipid content, decreased fetal lipid deposition is observed, placental PGC1 expression decreases, mitochondrial swelling increases, and placental total superoxide dismutase (T-SOD) activity increases. Both EPA and SIRT1 have no effect on BODIPY-FL-C16 uptake. Interestingly, there is no significant interaction between diet and genotype. Conclusion: Maternal EPA feeding decreases placental lipid deposition and improves placental oxidative stress homeostasis independent of SIRT1.

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Section: Discussionsupporting

confidence: 49%

Maternal Eicosapentaenoic Acid Feeding Decreases Placental Lipid Deposition and Improves the Homeostasis of Oxidative Stress Through a Sirtuin‐1 (SIRT1) Independent Manner

Peng

Xiong

Cui

et al. 2019

Molecular Nutrition Food Res

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“…Recently, Nrf1 was proposed in thermogenic fat cells as a metabolic guardian, avoiding tissue stress and inflammation independently of BAT differentiation, mass or expandability [34]. In addition, in a previous study we revealed that Ilex paraguariensis , rich in phenolic compounds, increased mitochondriogenesis and energy dissipation in brown adipose tissue and skeletal muscle, which explained the mass change of these oxidative tissues [35]. However, taking into account the lack of change in brown adipose tissue and gastrocnemius weights, and even more, in white adipose weights, it seems that under our experimental conditions, there was no sharp EE modification.…”

Section: Discussionmentioning

confidence: 93%

Potential Usefulness of a Wakame/Carob Functional Snack for the Treatment of Several Aspects of Metabolic Syndrome: From In Vitro to In Vivo Studies

et al. 2018

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Metabolic syndrome (MetS) greatly increases the risk of cardiovascular diseases and type 2 diabetes mellitus. The aim of this study was to evaluate the efficacy of functional snacks containing a combination of wakame (W) and carob pod (CP) flours in reducing markers associated with MetS. The mechanisms of action underlying these effects were also evaluated. In vitro approaches were carried out in mature 3T3-L1 adipocytes and RAW 264.7 macrophages treated with different doses of extracts from W, CP, or a combination of both. Furthermore, an in vivo experiment was conducted in rats with MetS treated with normal-caloric diets containing different snack formulations with combinations of 1/50 (snack A) or 1/5 of wakame/carob (snack B). In vitro experiments results indicated that both W and CP had delipidating effects, but only the latter induced anti-inflammatory and anti-hypertensive effects. As far as the in vivo study is concerned, snack B was ineffective and snack A showed an anti-hypertensive effect in rats with MetS. The present study shows for the first time the in vitro efficacy of a W and CP combination as an anti-inflammatory, delipidating, and anti-hypertensive tool, and its potential usefulness in treating MetS.

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“…Notably, the stated impacts had close bounded to bodyweight decline. Hence, yerba mate could relatively hinder diet-related obesity through escalating ATP consumption and induction of the biogenesis of mitochondria by AMPK/ SIRT1/PGC-1α-mediated cascade [94]. The green tea's efficacy on the biogenesis of mitochondria was investigated in vivo.…”

Section: Amla C2c12 Myotubesmentioning

confidence: 99%

Targeting Mitochondrial Biogenesis with Polyphenol Compounds

Chodari

Aytemir

Vahedi

et al. 2021

Oxidative Medicine and Cellular Longevity

118

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Appropriate mitochondrial physiology is an essential for health and survival. Cells have developed unique mechanisms to adapt to stress circumstances and changes in metabolic demands, by meditating mitochondrial function and number. In this context, sufficient mitochondrial biogenesis is necessary for efficient cell function and haemostasis, which is dependent on the regulation of ATP generation and maintenance of mitochondrial DNA (mtDNA). These procedures play a primary role in the processes of inflammation, aging, cancer, metabolic diseases, and neurodegeneration. Polyphenols have been considered as the main components of plants, fruits, and natural extracts with proven therapeutic effects during the time. These components regulate the intracellular pathways of mitochondrial biogenesis. Therefore, the current review is aimed at representing an updated review which determines the effects of different natural polyphenol compounds from various plant kingdoms on modulating signaling pathways of mitochondrial biogenesis that could be a promising alternative for the treatment of several disorders.

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Yerba Mate Stimulates Mitochondrial Biogenesis and Thermogenesis in High‐Fat‐Diet‐Induced Obese Mice

Abstract: YM stimulates mitochondriogenesis and Ucp expression, leading to an increase in the spare respiratory capacity and energy dissipation. These effects may help to better understand the potential use of YM for obesity treatment.

Cited by 16 publications

References 40 publications

Maternal Eicosapentaenoic Acid Feeding Decreases Placental Lipid Deposition and Improves the Homeostasis of Oxidative Stress Through a Sirtuin‐1 (SIRT1) Independent Manner

Maternal Eicosapentaenoic Acid Feeding Decreases Placental Lipid Deposition and Improves the Homeostasis of Oxidative Stress Through a Sirtuin‐1 (SIRT1) Independent Manner

Potential Usefulness of a Wakame/Carob Functional Snack for the Treatment of Several Aspects of Metabolic Syndrome: From In Vitro to In Vivo Studies

Targeting Mitochondrial Biogenesis with Polyphenol Compounds

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