Yersinia Enterocolitica: A New Cause of Erythema Nodosum

Mygind, Niels; Thulin, Hans

doi:10.1111/j.1365-2133.1970.tb06831.x

Cited by 17 publications

(4 citation statements)

References 4 publications

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“…Yersinia enterocolitrica, a gram-negative aerobic bacterium, is a member of the family Enterobacteriaceae, as are Salmonella, Escherichia coli and Shigella. In Scandinavia and France it is well known that Yersinia enterocolitica causes abdominal pain, diarrhea, fever, arthritis, and cutaneous mainfestations such as erythema nodosum or erythema multiforme, as does Yersinia pseudotuberculosis (1,2). Recently, human Yersinia infections have been reported from many countries throughout the world, i.e., Europe, North America, Africa and Asia (3,4).…”

Section: Introductionmentioning

confidence: 99%

Three Cases of Erythema Nodosum Associated with Yersinia Enterocolitica Infection

Ikeya

Mizuno

Takama

1986

The Journal of Dermatology

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Three cases of erythema nodosum associated with Yersinia enterocolitica infection were reported. They were diagnosed as Yersinosis following isolation of Yersinia enterocolitica from the feces and from serological investigation. The diagnosis was supported by the fact that Yersinia enterocolitica could be separated from the feces at an early stage of infection and that the serum agglutination titer for Yersinia enterocolitica increased within a month of infection. Clinically, the erythema nodosum preceded by abdominal pain and/or diarrhea was a complication of Yersinosis.

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Section: Introductionmentioning

confidence: 99%

Three Cases of Erythema Nodosum Associated with Yersinia Enterocolitica Infection

Ikeya

Mizuno

Takama

1986

The Journal of Dermatology

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“…infection of all types are considered [48], Most Swedish observers agree that EN due to Y.e. has a peak incidence among adult and older women, with approximately 50% of cases occurring after the age of 50 years in the pooled series of W in bla d [52], M y g in d and T h u l in [35], and A rvastson et at. [4] (table V).…”

Section: Sex Ratio and Age Distributionmentioning

confidence: 99%

“…[35], According to Winblad [52] abdominal symptoms as pain, diarrhoea or an appendicitis, are present in 60% of the cases. Other authors mention aches and/or fever during the prodromal period [18,34].…”

Section: Preceding and Concomitant Symptomsmentioning

confidence: 99%

Yersinia Enterocolitica as a Cause of Erythema nodosum

Debois¹,

Vandepitte²,

Degreef³

1978

Dermatology

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54 cases of erythema nodosum, seen in the Department of Dermatology at the St. Raphael University Hospital, Louvain, were reviewed for their possible aetiology. A search for Yersinia enterocolitica (Y.e.) agglutinins was performed in 21 patients of whom 8 had significant serum antibody titres. These cases are presented and discussed. Gastro-intestinal symptoms, preceding by 2 weeks the erythema nodosum, are strongly suggestive for an aetiologic link with Y.e. Our observations confirm and extend to this part of Europe, the experience of other, mainly Scandinavian, authors.

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“…Most commonly EN is due to bacterial and viral infections, sarcoidosis, systemic diseases and drugs. [11][12][13][14][15][16][17] As a neutrophilic vascular reaction of the small vessels in the subcutaneous fat tissue and an inflammatory infiltrate composed of PMN are common histopathological features at the initial stage of EN lesions, we addressed the question whether PMN might be activated in this disease. Furthermore, agents such as dapsone and potassium iodide have been used successfully in the treatment of EN, and both are known to act on PMN, 18,19 although the exact mechanism of their antiinflammatory activity is still unknown.…”

Section: Introductionmentioning

confidence: 99%

Leucocyte activation in erythema nodosum

Kunz¹,

Beutel²,

Bröcker³

1999

Clinical and Experimental Dermatology

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As a neutrophilic vascular reaction of small vessels in the subcutaneous tissue and a neutrophilic inflammatory infiltrate are common histopathological features found in initial erythema nodosum (EN) lesions, we asked the question whether activated polymorphonuclear neutrophils (PMN) might play a role in the pathogenesis of EN. We analysed the production of reactive oxygen intermediates (ROI) as a marker for activated neutrophils in the peripheral blood of patients suffering from EN (n = 10) and healthy volunteers (n = 10). FACS analysis of dihydrorhodamine 123-stained PMN was used to detect ROI production due to respiratory burst activity. Patients suffering from EN had a fourfold higher percentage of preactivated ('primed') ROI-producing PMN compared with healthy volunteers. Activation of PMN with formylated methionyl-leucyl-phenylalanine and phorbol 12-myristate 13-acetate led to an increase of ROI production per cell but had no influence on the percentage of activated cells. The percentage of ROI-producing cells in patients with EN correlated with the clinical severity. From these data, we conclude that ROI might play a role in the pathogenesis of EN. ROI might exert their effects by oxidative tissue damage and by promoting tissue inflammation.

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Yersinia Enterocolitica: A New Cause of Erythema Nodosum

Cited by 17 publications

References 4 publications

Three Cases of Erythema Nodosum Associated with Yersinia Enterocolitica Infection

Three Cases of Erythema Nodosum Associated with Yersinia Enterocolitica Infection

Yersinia Enterocolitica as a Cause of Erythema nodosum

Leucocyte activation in erythema nodosum

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