Yersinia Enterocolitica Liver Abscesses Unmasking Idiopathic Hemochromatosis

Santoro, Michael J.; Chen, Yang K.; Seid, Neil S.; Abdulian, J D; Collen, Martin J.

doi:10.1097/00004836-199404000-00024

Cited by 13 publications

(4 citation statements)

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“…A commonly recognized example is Yersinia infection in patients with HHC where increased iron is believed to heighten the virulence of the organism. [30][31][32][33][34][35] In addition, several other infections including fatal Listeria meningitis, endocarditis, and pericarditis, zygomycosis, Plesiomonas shigelloides, gramnegative septic shock, mucormycosis, and Vibrio vulnificus have all been reported in patients with HHC. [36][37][38][39][40][41][42] Immune dysfunction and increased susceptibility to infection also has been demonstrated in patients and animals with secondary forms of iron overload.…”

Section: Discussionmentioning

confidence: 99%

Iron overload in cirrhosis— HFE genotypes and outcome after liver transplantation

et al. 2000

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Previously, we found appreciable hepatic iron deposition in one third of our patients undergoing liver transplantation (LTx) with approximately 10% of cases having quantifiable iron in the range of that seen in hereditary hemochromatosis (HHC). The aim of this study was to compare clinical outcome in liver transplant patients with and without iron overload. We also sought to determine the prevalence of HFE mutations in liver transplant patients with iron overload. Of 456 consecutive liver transplants, 41 explants had an hepatic iron index (HII) greater than 1.9, and these cases were compared to 41 matched liver transplant recipients without increased hepatic iron. Posttransplantation complications, along with patient and graft survival were monitored. HFE gene testing was performed using DNA-based techniques. Kaplan-Meier 5-year patient survival after LTx was significantly lower in cases with hepatic iron overload compared to matched controls without iron excess (48% vs.

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Section: Discussionmentioning

confidence: 99%

Iron overload in cirrhosis— HFE genotypes and outcome after liver transplantation

et al. 2000

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“…224 Abscesses secondary to Yersinia enterocolitica or Yersinia pseudotuberculosis are often associated with underlying hemochromatosis. [225][226][227][228] Anaerobes are isolated in up to 25% of cases, sometimes together with aerobes. 218,229,230 Microaerophilic streptococci, Bacteroides fragilis, Fusobacterium necrophorum, and Clostridium spp.…”

Section: Pyogenic Liver Abscessmentioning

confidence: 99%

Liver and Bile Duct Infections

Masia¹,

Misdraji²

2018

Diagnostic Pathology of Infectious Disease

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“…143 Abscesses secondary to Yersinia enterocolitica or Yersinia pseudotuberculosis are often associated with underlying hemochromatosis. [144][145][146][147] Anaerobes are isolated in up to 25% of cases, sometimes together with aerobes. 139,148,149 Microaerophilic streptococci, Bacteroides fragilis, Fusobacterium necrophorum, and Clostridium spp.…”

Section: Bacillus Calmette-guérinmentioning

confidence: 99%

Liver and Bile Duct Infections

Misdraji¹

2010

Diagnostic Pathology of Infectious Disease

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Yersinia Enterocolitica Liver Abscesses Unmasking Idiopathic Hemochromatosis

Cited by 13 publications

References 0 publications

Iron overload in cirrhosis— HFE genotypes and outcome after liver transplantation

Iron overload in cirrhosis— HFE genotypes and outcome after liver transplantation

Liver and Bile Duct Infections

Liver and Bile Duct Infections

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