Yersinia enterocolitica mesenteric adenitis in a thalassaemic adolescent

Yersinia EnterocoliticaColitis with Peritonitis in a Child with Beta-Thalassemia Major

“…[3][4][5] Occasionally, it can also lead to fulminant septicemia and peritonitis. [6][7][8][9] Interestingly, the majority of reported infections have been in patients with iron overload, 6,7,9 those receiving desferoxamine, [3][4][5] or in those whose host defenses are compromised, including those with HIV 10 and liver disease. 7 In a review of 12 cases of Yersinia enterocolitica peritonitis, Reed et al found that six (50%) of them had iron overload.…”

“…3 It is well known that continuing desferoxamine administration will lead to exacerbation of the illness by encouraging the systemic spread of Yersinia. In our patient, it was a difficult decision not to operate because he had signs of peritonitis, but retrospectively, if Yersinia enterocolitica was diagnosed preoperatively, colon resection could have been avoided since there was no perforation and the area of inflammation was localized affecting about 15 cm of the transverse colon.…”

Iron Chelation as a Potential Therapeutic Approach in Acute Lung Injury

“…In turn, the degradation of ferroportin in macrophages not only limits the availability of iron to bacteria, but also promotes tissue restoration, eventually attenuating lung injury induced by pneumonia. In addition, iron overload is associated with the increased virulence of multiple microbes, including Yersinia enterocolitica , Escherichia coli, and Klebsiella pneumonia [ 24 , 64 , 65 ]. During infection, the body uses some iron-binding proteins to control the iron supply accessible to microbes, such as neutrophil gelatinase–associated lipocalin (NGAL or lipocalin-2), lactoferrin, and natural resistance–associated macrophage protein 1 (NRAMP1).…”