YES-10 Improves Stress, Tension, and Fatigue by Reducing Cortisol and IL-6 Levels

Noh, Yoohun; Hong, Junkee; Lee, Jiwon; Kim, Sung‐Su; Kang, Il‐Jun; Whang, Wan Kyunn; Myung, Soon‐Chul; Chung, Myung‐Hee; Won, Moo‐Ho

doi:10.1089/jmf.2021.k.0129

Cited by 1 publication

(3 citation statements)

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“…In a previous study [ 15 ], Fameyes was observed to relieve mental stress in human subjects by improving test scores that measured the levels of depression, anxiety, well-being, and mental fitness. In addition to these subjective findings, the present study presents objective findings supporting the anti-stress activity of Fameyes through in vitro and in vivo experiments.…”

Section: Discussionmentioning

confidence: 99%

“…Fameyes has been reported to protect against ischemia–reperfusion injury in rodent brains, suggesting its ROS-scavenging property [ 13 , 14 ]. In addition to suppressing oxidative stress in brain tissues, Fameyes was observed to relieve mental stress in human subjects [ 15 ]. Furthermore, it was recently reported as a reactive oxygen species (ROS) scavenger [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, it was recently reported as a reactive oxygen species (ROS) scavenger [ 11 ]. In this study, oral administration of YES‑10® (200 mg) for four weeks substantially improved the test scores of the patients on the Beck Depression Inventory, Beck Anxiety Inventory, Psychosocial General Well-Being Index, and Mental Fitness Scale, which are psychometric tests to measure levels of depression, anxiety, well-being, and mental fitness, respectively [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

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Anti-stress effects of Fameyes in in vitro and in vivo models of stresses

Hong¹,

Lee

Kim³

et al. 2022

Lab Anim Res

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Background Fameyes (a mixture of Clematis mandshurica Rupr. extract (CMRE) and Erigeron annuus (L.) Pers. extract (EAPE)) containing scutellarin and chlorogenic acid as major components has been reported to relieve mental stress in human subjects, which is reflected in improved scores in psychometric tests measuring levels of depression, anxiety, well-being, and mental fitness. The aim of this study was to examine the anti-stress activity of Fameyes and to investigate the mechanisms of the anti-stress activity using in vitro and in vivo models of stresses. Results First, we tested the effect of Fameyes on corticosterone-induced cytotoxicity in SH-SY5Y cells (human neurofibroma cell lines). Corticosterone induced apoptosis and decreased cell viability and mitochondrial membrane potential, but treatment with Fameyes inhibited these cytotoxic effects in a dose-dependent manner. However, CMRE and EAPE (components of Fameyes) did not inhibit the cytotoxic effect of corticosterone individually. Next, we tested the effects of Fameyes on rats that were exposed to different kinds of stresses for four weeks. When the stressed rats were treated with Fameyes, their immobility time in forced swim and tail suspension tests decreased. A reduction was also observed in the serum levels of adrenocorticotropic hormone (ACTH) and corticosterone. Furthermore, upon oral administration of Fameyes, serum serotonin levels increased. These in vitro and in vivo results support the anti-stress effects of Fameyes. Conclusions In vitro experiments showed anti-stress effects of Fameyes in cell viability, apoptosis, and mitochondrial membrane potential. In addition, in vivo experiments using rats showed anti-stress effects of Fameyes in blood and tissue levels of ACTH, corticosterone, and serotonin, as well as the immobility time in the forced swim and tail suspension tests. However, we did not specifically investigate which ingredient or ingredients showed anti-stress effects, although we reported that Fameyes contained chlorogenic acid and scutellarin major ingredients.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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