Two field experiments were conducted at Sakha Station, Cotton Research Institute, Agricultural Research Center, during 2010 and 2011 seasons, to investigate the impact of irrigation interval, defoliant type and defoliation time on the yield, yield components and fiber properties of the Egyptian cotton (G. barbadense, L.) variety Giza 92 . Split Split plot design with four replicates was used. The irrigation intervals (I) occupied the main plots as follows:(I 1 ) normal irrigation ( at two-week interval) , normal irrigation (at two week interval) until flowering then increasing time to 4 week interval (I 2 ) , and four week interval (I 3 ). The second factor defoliant type (D) occupied the sub-plots with three levels: ˝Dropp˝ defoliant-(D 1 ) , ˝Prep˝ defoliant -(D 2 ), and control spraying with water-(D 3 ).The third factor, time of defoliant application (T) was distributed randomly in the sub-sub plots as follows: defoliant spray after 60% of bolls open (T ! ) , spraying after 70% of bolls open (T 2 ),spraying after 80% of bolls are open (T 3 ). The effects of all main factors were significant in both seasons except for the effect of spraying date on the no. of fruiting branches. The significance of the interaction varied according to the cotton trait. The results revealed that the best irrigation treatment is the 15-days interval throughout the growing season. The ˝Dropp˝ defoliant generally surpassed the ˝Prep˝ defoliant in affecting all characters under study. The application of defoliant after 60% of bolls are open resulted in the highest value of all traits under study except the number of fruiting branches in both seasons. It was concluded that normal irrigation coupled with the application of the defoliant ˝Dropp˝ after 60 % of bolls are open had a positive effect on the cotton agronomic traits, cotton yield and cotton fiber characteristics .