Yield-enhancement of a large systolic array chip

Moore, W. G.; Day, Michael

doi:10.1016/0026-2714(84)90477-3

Cited by 11 publications

(1 citation statement)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The evidence in experimental models suggest that VIP may influence the tissue distribution of lymphocytes. In vivo studies carried out by Moore and collaborators [50,51] showed that direct infusion of VIP into afferent…”

Section: Lymphocyte Adhesion and Trafficmentioning

confidence: 98%

Immunology of VIP: A Review and Therapeutical Perspectives

Gomariz

Martı́nez²,

Abad³

et al. 2001

CPD

148

135

View full text Add to dashboard Cite

Vasoactive intestinal peptide (VIP) is a neuropeptide with a broad distribution in the body that exerts very important pleiotropic functions in several systems. The present work reviews the immunology of VIP. Being daring, this neuropeptide could be included in the group of cytokines since it is produced and secreted by different immunocompetent cells in response to various immune signals, plays a broad spectrum of immunological functions, and exerts them, in a paracrine and/or autocrine way, through three different specific receptors. Although VIP has been classically considered as an immunodepressant agent, and its main described role has been as an anti-inflammatory factor, several evidences suggest that a better way to see this peptide is as a modulator of the homeostasis of the immune system. In the last decade, the pharmacology of VIP has spectacularly grown, and VIP itself, as well as more stable VIP-derived agents, have been used or proposed as efficient therapeutical treatments of several disorders, specially inflammatory and autoimmune diseases, such as septic shock, rheumatoid arthritis, multiple sclerosis, Crohn's disease and autoimmune diabetes. A broad field of perspectives is actually open, and further investigations will help us to definitively understand the immunology of this very important peptide.

show abstract

Section: Lymphocyte Adhesion and Trafficmentioning

confidence: 98%